DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp70Aa and HYOU1

DIOPT Version :10

Sequence 1:NP_731651.1 Gene:Hsp70Aa / 48581 FlyBaseID:FBgn0013275 Length:642 Species:Drosophila melanogaster
Sequence 2:NP_001397970.1 Gene:HYOU1 / 10525 HGNCID:16931 Length:1000 Species:Homo sapiens


Alignment Length:794 Identity:203/794 - (25%)
Similarity:340/794 - (42%) Gaps:195/794 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MPAIGIDLGTTYSCVGVYQHG-KVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTV 64
            :..:.:|||:....|.:.:.| .:||:.|.:..|.||..|...::||..||.|.:....||:.|:
Human    33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATL 97

  Fly    65 FDAKRLIGRKYDDPKIAEDMKHWP-FKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETA 128
            ...:.|:|::.|:|.:|.....:| .::..|..:..:..:...: .:|:|||:..|||...:..|
Human    98 RYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQ-LQFSPEEVLGMVLNYSRSLA 161

  Fly   129 EAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGL----DKNLKGE 189
            |.:..:.|.|||||||.:||.::|:|...|..:|||.||::||:.||.||:||:    |.|...:
Human   162 EDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQ 226

  Fly   190 RNVLIFDLGGGTFDVSILTID-----EGSL---FEVRSTAGDTHLGGEDFDNRLVTHLADEFKRK 246
             |::.:|:|.|:...:|:|..     |..:   .::|....|..|||.:.:.||...||..|..:
Human   227 -NIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQ 290

  Fly   247 YK----KDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADL 307
            .|    ||:|.||||:.:|...|.|.|..||::.:...:|:.|.:..||..||:|..||||||||
Human   291 RKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADL 355

  Fly   308 FRNTLQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAA 372
            |.....||::||..|:|...:|..::||||:||:|:||.:|......:.|..:||.|||.|.||.
Human   356 FERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAV 420

  Fly   373 VQAAILSGDQSGKIQDVLLVD--VAPL----SLGIETAGGVMTKLIERNCRI--------PCKQT 423
            .|||.||  ::.|::..::.|  |.|:    :..:|...|:.:  ::.|.|:        |.::.
Human   421 YQAAALS--KAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHS--LKHNKRVLFSRMGPYPQRKV 481

  Fly   424 KTFSTYAD------NQPGVSIQVYEGERAMTKDNNALGTFDLSGIPPAPRGVPQ-----IEVTFD 477
            .||:.|:.      |...:.....|..|.....|  |.|..|.|:..:.:..|.     |:..|:
Human   482 ITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQN--LTTVKLKGVGDSFKKYPDYESKGIKAHFN 544

  Fly   478 LDANGILNV-------------SAKEMSTGKAKNITI---------------------------- 501
            ||.:|:|::             ||:|.||......||                            
Human   545 LDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPA 609

  Fly   502 --------------------------------------------KNDKGRLSQA----------- 511
                                                        :.:.|..|:|           
Human   610 EGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGP 674

  Fly   512 -----------------------EI--------------DRMVNEAEKYAD---EDEKHRQRITS 536
                                   ||              |::....:|..|   .|.:.::|..:
Human   675 EGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKA 739

  Fly   537 RNALESYVFNVKQAVEQAPAGKLD-EADKNSVLDKCNDTIRWLDSN----TTAEKEEFDHKLEEL 596
            .|:||:::|..:..:.|....::. |..:..:..|.:....||:..    ||...:|   ||.||
Human   740 ANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKE---KLAEL 801

  Fly   597 TRHCSPIMTKMHQQ 610
            .:.|..:..::.::
Human   802 RKLCQGLFFRVEER 815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp70AaNP_731651.1 PTZ00009 2..642 CDD:240227 203/793 (26%)
HYOU1NP_001397970.1 ASKHA_NBD_HSP70_HYOU1 34..424 CDD:466828 138/391 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 578..694 5/115 (4%)
LGT <593..694 CDD:469786 3/100 (3%)
Prevents secretion from ER. /evidence=ECO:0000255 997..1000
Blue background indicates that the domain is not in the aligned region.

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