Protein Alignment hbn and Pitx2

DIOPT Version :10

• Sequence 1: NP_788420.1
• Gene: hbn / 47894
• FlyBaseID: FBgn0008636
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_001035970.1
• Gene: Pitx2 / 54284
• RGDID: 3331
• Length: 324
• Species: Rattus norvegicus
• Alignment Length: 284
• Identity: 90/284 - (31%)
• Similarity: 135/284 - (47%)
• Gaps: 50/284 - (17%)

  Fly    98 HHSQ--------QQQQQQQLQVQAKREDSPTNTD-GGLDVDNDDELSSSLNNGHDLSDMERPRKV 153
            ||:|        ...|.:.|.....|.:..|.:| ...:|...|:.....|......|..:.::.
  Rat    28 HHTQALAMASVLAPGQPRSLDASKHRLEVHTISDTSSPEVAEKDKGQQGKNEDVGAEDPSKKKRQ 92

  Fly   154 RRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAKWRKREKFMNQD 218
            ||.||.||:.||.:||..|::.:|||:.|||::|:..:|:||||:|||:||||||||||:  ||.
  Rat    93 RRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRER--NQQ 155

  Fly   219 KAGYLLPEQGL-PEFPLGIPLPPHGLPGHPGSMQSEFWPPHFALHQHFNPAAAAAAGLLPQHLMA 282
            ..   |.:.|. |:|              .|.||     |:..::..::....||.||....|..
  Rat   156 AE---LCKNGFGPQF--------------NGLMQ-----PYDDMYPGYSYNNWAAKGLTSASLST 198

  Fly   283 ---PHYKLPNFHTLLSQYMGLSNLNGIFGAG-AAAAAAAASAGYPQNLSLHAGLSAMSQVSPPCS 343
               |.:...|.:.|.||.| .|..|.|.... :::...:|..|.|.: ||:: |:.::.:|.|..
  Rat   199 KSFPFFNSMNVNPLSSQSM-FSPPNSISSMSMSSSMVPSAVTGVPGS-SLNS-LNNLNNLSSPSL 260

  Fly   344 NSSPRESPKLVPHPTPPHA--TPP 365
            ||:       ||.|..|:|  |||
  Rat   261 NSA-------VPTPACPYAPPTPP 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hbn	NP_788420.1	Homeodomain	154..210	CDD:459649	32/55 (58%)
Pitx2	NP_001035970.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	57..111		16/53 (30%)
		Homeodomain	93..149	CDD:459649	32/55 (58%)
		OAR	282..299	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	286..299
		Nuclear localization signal. /evidence=ECO:0000255	292..296