Protein Alignment Abd-B and PDX1

DIOPT Version :10

• Sequence 1: NP_524896.2
• Gene: Abd-B / 47763
• FlyBaseID: FBgn0000015
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_000200.1
• Gene: PDX1 / 3651
• HGNCID: 6107
• Length: 283
• Species: Homo sapiens
• Alignment Length: 212
• Identity: 63/212 - (29%)
• Similarity: 86/212 - (40%)
• Gaps: 44/212 - (20%)

  Fly   272 YYDRKHMFAYPYPETQFPVGQYWGPNYRPDQTTSAAAAAAYMNE----AERHVSAAARQSVEGTS 332
            ||....::..|....:.|..::          :::..|..||..    ...|....|..::|..|
Human     7 YYAATQLYKDPCAFQRGPAPEF----------SASPPACLYMGRQPPPPPPHPFPGALGALEQGS 61

  Fly   333 ---TSSYE-PPTYSSPGGLR-----------GYPSENYSSSGASGGL-----SVGAVGPCTPNPG 377
               .|.|| ||....|....           .:|.......||..|:     .|....|...:..
Human    62 PPDISPYEVPPLADDPAVAHLHHHLPAQLALPHPPAGPFPEGAEPGVLEEPNRVQLPFPWMKSTK 126

  Fly   378 LHEWTGQ----------VSVRKKRKPYSKFQTLELEKEFLFNAYVSKQKRWELARNLQLTERQVK 432
            .|.|.||          ...::.|..|::.|.||||||||||.|:|:.:|.|||..|.||||.:|
Human   127 AHAWKGQWAGGAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIK 191

  Fly   433 IWFQNRRMKNKKNSQRQ 449
            |||||||||.||...::
Human   192 IWFQNRRMKWKKEEDKK 208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abd-B	NP_524896.2	Homeodomain	388..444	CDD:459649	34/55 (62%)
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73		13/69 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..71		10/36 (28%)
		Antp-type hexapeptide	118..123		1/4 (25%)
		Homeodomain	147..203	CDD:459649	34/55 (62%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		4/5 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		2/8 (25%)