Protein Alignment SrpRalpha and SRP101

DIOPT Version :10

• Sequence 1: NP_524887.2
• Gene: SrpRalpha / 47251
• FlyBaseID: FBgn0010391
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_010578.3
• Gene: SRP101 / 851886
• SGDID: S000002700
• Length: 621
• Species: Saccharomyces cerevisiae
• Alignment Length: 678
• Identity: 204/678 - (30%)
• Similarity: 321/678 - (47%)
• Gaps: 123/678 - (18%)

  Fly     1 MLDFVVIFTKGGVVLWHSNASGNSFASC-INSLIRGVI---------LEERNTE----------A 45
            |.|.:.:||..|.||:..|..|..|:.. |||.|..:|         :...||:          :
Yeast     1 MFDQLAVFTPQGQVLYQYNCLGKKFSEIQINSFISQLITSPVTRKESVANANTDGFDFNLLTINS 65

  Fly    46 KYYEEDHLAVQFKLDNELDLVYAAIF-QKVIKLNYLDGFLADMQ---AAFKEKYGDIRLGDDYDF 106
            ::.........|.|:.:.:|.:...| ::.::||      .:.|   |...:.:..:.|.:....
Yeast    66 EHKNSPSFNALFYLNKQPELYFVVTFAEQTLELN------QETQQTLALVLKLWNSLHLSESILK 124

  Fly   107 DREYRRVLSAAEEASAKQVKAPKTMRSYNESQKSKKTVASMIQ---DDKKPVEK--RVNIQEAPP 166
            :|:                         .:::|:|.....::|   ||.|..|:  |:..:|:
Yeast   125 NRQ-------------------------GQNEKNKHNYVDILQGIEDDLKKFEQYFRIKYEES-- 162

  Fly   167 PSKSQPSSPPTGSPMDKIIMEKRRKLREKLTPTKKTSPSDSKSSKPEKAGKKPRVWDLGG----- 226
             .|....:|...:....:.....:..::||..||....|........|.|:.      ||
Yeast   163 -IKQDHINPDNFTKNGSVPQSHNKNTKKKLRDTKGKKQSTGNVGSGRKWGRD------GGMLDEM 220

  Fly   227 NSKDAALLD----RSRDSPDDVQYQNINSELVG--TMQG--VIRDLDVESEDEADNEDASSEGEA 283
            |.:|||.||    .|.:|........||.:..|  |..|  :|:::|          |..| ...
Yeast   221 NHEDAAKLDFSSSNSHNSSQVALDSTINKDSFGDRTEGGDFLIKEID----------DLLS-SHK 274

  Fly   284 EEQVQSKKGKRGGLLS-----YFKGIVGAKTMSLADLQPALEKMRDHLISKNVASEIAAKLCDSV 343
            :|.....:.|..|.:|     ..|.::|.||::.:||:..|||:...||:||||.|.|..|...|
Yeast   275 DEITSGNEAKNSGYVSTAFGFLQKHVLGNKTINESDLKSVLEKLTQQLITKNVAPEAADYLTQQV 339

  Fly   344 AASLDGKQMGTFDSIASQVKEALTESLVRILSPKRRIDIIRDALESKRNGR-------PYTIIFC 401
            :..|.|.:...:.|:.:..:|:||::|.:||:|...:|::|: ::|||:.:       ||.....
Yeast   340 SHDLVGSKTANWTSVENTARESLTKALTQILTPGVSVDLLRE-IQSKRSKKDEEGKCDPYVFSIV 403

  Fly   402 GVNGVGKSTNLAKICFWLIENDFNVLIAACDTFRAGAVEQLRTHTRHLNAL----HPAAKHD--- 459
            |||||||||||:|:.|||::|:|.|||.||||||:|||||||.|..:|..|    |.....:
Yeast   404 GVNGVGKSTNLSKLAFWLLQNNFKVLIVACDTFRSGAVEQLRVHVENLAQLMDDSHVRGSKNKRG 468

  Fly   460 --GRNMVQLYEKGYGKD--AAGIAMEAIKFAHDTRVDVVLVDTAGRMQDNEPLMRSLSKLIKVNN 520
              |.:.|:|:|.|||..  ...||.:|||::.|...|:||:|||||..::..||..|........
Yeast   469 KTGNDYVELFEAGYGGSDLVTKIAKQAIKYSRDQNFDIVLMDTAGRRHNDPTLMSPLKSFADQAK 533

  Fly   521 PDLVLFVGEALVGNEAVDQLVKFNQSLADYSSNENPHIIDGIVLTKFDTIDDKVGAAISMTYITG 585
            ||.::.|||||||.::|.|...||.:   :....|   :|..:::|.||:.:.:|..::|.|.||
Yeast   534 PDKIIMVGEALVGTDSVQQAKNFNDA---FGKGRN---LDFFIISKCDTVGEMLGTMVNMVYATG 592

  Fly   586 QPIVFVGTGQTYADLKAINVNAVVNSLM 613
            .||:|||.||||.||:.::|...||:||
Yeast   593 IPILFVGVGQTYTDLRTLSVKWAVNTLM 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SrpRalpha	NP_524887.2	SRP-alpha_N	28..267	CDD:461165	52/280 (19%)
		FlhF	<258..500	CDD:274609	100/266 (38%)
		SRalpha_C	396..612	CDD:349785	99/226 (44%)
SRP101	NP_010578.3	SRX	1..155	CDD:370358	34/184 (18%)
		SRP54_N	300..370	CDD:460734	25/69 (36%)
		SRalpha_C	398..619	CDD:349785	99/226 (44%)