Protein Alignment SrpRalpha and SRPRA

DIOPT Version :10

• Sequence 1: NP_524887.2
• Gene: SrpRalpha / 47251
• FlyBaseID: FBgn0010391
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: XP_047283453.1
• Gene: SRPRA / 6734
• HGNCID: 11307
• Length: 688
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 308/614 - (50%)
• Similarity: 412/614 - (67%)
• Gaps: 49/614 - (7%)

  Fly     1 MLDFVVIFTKGGVVLWHSNASGNSFASCINSLIRGVILEERNTEAKYYEEDHLAVQFKLDNELDL 65
            ||||..||:|||:|||......:|....:|:|||.|:|:||.....:..| .|.:::||||:.:|
Human     1 MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQERGGNNSFTHE-ALTLKYKLDNQFEL 64

  Fly    66 VYAAIFQKVIKLNYLDGFLADMQAAFKEKY-GDIR-------LGDDYDFDREYRRVLSAAEEASA 122
            |:...|||::.|.|:|..:.|:...|::|| .:|:       |...:||..::.|:|..|||:|
Human    65 VFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFDFQNDFLRLLREAEESS- 128

  Fly   123 KQVKAPKTMRSYNESQKSKKTVASMIQD-DKKPVEKRVNIQE---------------APPPSKSQ 171
             :::||.||:.:.:|:|:||.|.|||:. .:||.||..|.::               .|.|::..
Human   129 -KIRAPTTMKKFEDSEKAKKPVRSMIETRGEKPKEKAKNSKKKGAKKEGSDGPLATSKPVPAEKS 192

  Fly   172 --PSSPPTGSPMDK--IIMEKRRKLREKLTPTKKTSPSDSKSSKPEKAGKK-PRVWDLGGNSKDA 231
              |..|..|..:.|  :|..||.:..:|.....:.|...:||..|::.||| ||||:||| ..:.
Human   193 GLPVGPENGVELSKEELIRRKREEFIQKHGRGMEKSNKSTKSDAPKEKGKKAPRVWELGG-CANK 256

  Fly   232 ALLDRS----RDSPDDVQYQNINSELVGT-MQGVIRDLDVESEDEADNEDASSEGEAEEQVQ--S 289
            .:||.|    ..:|:....::||. :.|| ..|.::|||..|.|:        ||.|:...:  :
Human   257 EVLDYSTPTTNGTPEAALSEDINL-IRGTGSGGQLQDLDCSSSDD--------EGAAQNSTKPSA 312

  Fly   290 KKGKRGGLLSYFKGIVGAKTMSLADLQPALEKMRDHLISKNVASEIAAKLCDSVAASLDGKQMGT 354
            .||..||:....||:||:|::|..|::..|:|||||||:||||::||.:||:|||..|:||.|||
Human   313 TKGTLGGMFGMLKGLVGSKSLSREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGT 377

  Fly   355 FDSIASQVKEALTESLVRILSPKRRIDIIRDALESKRNGRPYTIIFCGVNGVGKSTNLAKICFWL 419
            |.::.|.||:||.||||:||.|:||:|::||.::::|..|||.:.||||||||||||||||.|||
Human   378 FSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRRQRPYVVTFCGVNGVGKSTNLAKISFWL 442

  Fly   420 IENDFNVLIAACDTFRAGAVEQLRTHTRHLNALHPAAKHDGRNMVQLYEKGYGKDAAGIAMEAIK 484
            :||.|:||||||||||||||||||||||.|:||||..||.||.||||:||||||||||||||||.
Human   443 LENGFSVLIAACDTFRAGAVEQLRTHTRRLSALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIA 507

  Fly   485 FAHDTRVDVVLVDTAGRMQDNEPLMRSLSKLIKVNNPDLVLFVGEALVGNEAVDQLVKFNQSLAD 549
            ||.:...||||||||||||||.|||.:|:|||.||.||||||||||||||||||||||||::|||
Human   508 FARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALAD 572

  Fly   550 YSSNENPHIIDGIVLTKFDTIDDKVGAAI 578
            :|..:.|.:||||||||||||||||...:
Human   573 HSMAQTPRLIDGIVLTKFDTIDDKVNVRL 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SrpRalpha	NP_524887.2	SRP-alpha_N	28..267	CDD:461165	89/272 (33%)
		FlhF	<258..500	CDD:274609	149/243 (61%)
		SRalpha_C	396..612	CDD:349785	144/183 (79%)
SRPRA	XP_047283453.1	SRP-alpha_N	28..296	CDD:461165	89/272 (33%)
		FlhF	<301..523	CDD:274609	143/221 (65%)
		SRalpha_C	419..597	CDD:349785	142/177 (80%)