Protein Alignment Fur1 and TPP2

DIOPT Version :10

• Sequence 1: NP_001262954.1
• Gene: Fur1 / 47220
• FlyBaseID: FBgn0004509
• Length: 1478
• Species: Drosophila melanogaster
• Sequence 2: NP_193817.2
• Gene: TPP2 / 827833
• AraportID: AT4G20850
• Length: 1380
• Species: Arabidopsis thaliana
• Alignment Length: 1517
• Identity: 286/1517 - (18%)
• Similarity: 457/1517 - (30%)
• Gaps: 533/1517 - (35%)

  Fly    87 TSFLTQHKQKRSGKSSSKSKSNRSRPLAKTKAVFLLALQFSAVVFLCNINVGFVAGSVATAASSA 151
            ::||...:.:|  :|.|:|:..|.|...           |||:.  |:.:....|..|.......
plant    40 STFLLHRRLRR--RSCSRSRGIRLRRSG-----------FSAMP--CSSSDTLTASRVGCGGGGG 89

  Fly   152 GGSSPAAPSSAP-------SSPPTVAVPPP-----------------------------PPPSSA 180
            ||:......:|.       .|....::.|.                             .|.::.
plant    90 GGAVGGGAENASVANFKLNESTFIASLMPKKEIRADCFIEAHPEYDGRGVVIAIFDSGFDPSAAG 154

  Fly   181 LKVDPNGQSPVLPPYVLDYETGGKAKLTPNNGKFGQSGSSGSNNNHIVGHYTHTWAVHI----PN 241
            |.|..:|:..||.  |:|. ||.....|....|..:.|       ||.|....|..|:.    |.
plant   155 LHVTSDGKPKVLD--VIDC-TGSGDIDTSTVVKANEDG-------HIRGASGATLVVNSSWKNPT 209

  Fly   242 GD-------------NGMADAVAKDH-------GFVNLGKIFDDHYHF--AHHKVSKRSLSPATH 284
            |:             :.:...|.|:.       ....:.|..::.|.|  .|.||....|
plant   210 GEWRVGSKLVYQLFTDDLTSRVKKERRKSWDEKNQEEIAKAVNNLYDFDQKHSKVEDAKL----- 269

  Fly   285 HQTRLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGL 349
                          |:.|...:||.||::.:..:...:. .::||:.::|.:
plant   270 --------------KKTREDLQSKVDFLKKQADKYEDKG-PVIDAVVWHDGE------------- 306

  Fly   350 DMNVIPAWKMGITGKGVVVTILDDGLESDHPD---IQD-----NYDPKASYDV-----------N 395
                  .|:         |.:....||.| ||   :.|     ||..:..|.|           |
plant   307 ------VWR---------VALDTQSLEED-PDSGKLADFSPLTNYRIERKYGVFSRLDACSFVAN 355

  Fly   396 SHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDV----TDAVEA 456
            .:|:..:... :|||:.|||..||...|.........|:|.||.:...::.|..:    |.....
plant   356 VYDEGKVLSI-VTDSSPHGTHVAGIATAHHPEEHLLNGVAPGAQIISCKIGDSRLGSMETGTGLT 419

  Fly   457 RSLSLNPQH-IDIYSASWGP----DDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGG 516
            |:|....:| .|:.:.|:|.    .|.|:.||        ...|...|.|    .||:.::||.|
plant   420 RALIAALEHNCDLVNMSYGEPALLPDYGRFVD--------LVTEAVNKRR----LIFVSSAGNSG 472

  Fly   517 REQDNCNCDGYTNS--------------IWTLSISSATEEG-HVPWYSEKCSS--TLATTYSSGG 564
            .........|.|.|              ....|:.....|| ...|.|...:|  .|....|:.|
plant   473 PALTTVGAPGGTTSSIIGVGAYVSPAMAAGAHSVVEPPSEGLEYTWSSRGPTSDGDLGVCISAPG 537

  Fly   565 QGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQ----NLTWRDLQHIVVRTAKP-AN 624
            .....|.|..|.....::  |||.::|.|.|..||:|.:.:    .::...::..:..|:.| .:
plant   538 GAVAPVPTWTLQRRMLMN--GTSMASPSACGAIALLLSAMKAEGIPVSPYSVRRALENTSTPVGD 600

  Fly   625 LKDPSWSRNGVGRRVSHSFGYGLMD---AAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTHI 686
            |.:...:.           |.|||.   |.|.::..:::..|..|.:..::.    |.||....|
plant   601 LPEDKLTT-----------GQGLMQVDKAYEYLKQFQDYPCVFYQIKVNLSG----KTIPTSRGI 650

  Fly   687 TLQLTVNHCRSVNYLEHVQAK---------------------------------ITLTSQRRG-- 716
            .|:......:|..:...|..|                                 :.||:..||
plant   651 YLREGTACRQSTEWTIQVDPKFHEGASNLKELVPFEECLELHSTDEGVVRVPDYLLLTNNGRGFN 715

  Fly   717 --------------------DIQLFLRSPA-NTSVTLLTPRIHDNSRS--GFNQWPFMSVH---- 754
                                |.:...|.|. ...||::.|:...|...  .|.|..|:|.|
plant   716 VVVDPTNLGDGVHYFEVYGIDCKAPERGPLFRIPVTIIIPKTVANQPPVISFQQMSFISGHIERR 780

  Fly   755 --------TWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGTTQSIGP-NDPI---SVP---K 804
                    ||.|:..           |..|....|.    ||..|..:.| ..||   |.|   .
plant   781 YIEVPHGATWAEATM-----------RTSGFDTTRR----FYIDTLQVCPLRRPIKWESAPTFAS 830

  Fly   805 PSGSEATTPNSSSTTSNLHQAYSPQYPRIPPNNFGSSPSG------------------------- 844
            ||......|..|..|..|..|           .|.||..|
plant   831 PSAKSFVFPVVSGQTMELAIA-----------QFWSSGLGSREPTIVDFEIEFHGVGVDKEELLL 884

  Fly   845 -GSKLPLGKVPPPN--KSSYVTNNPLLNSAPPKQGYQQISATYGVILGKANGKSNNNSKEKTNNK 906
             ||:.|: ||....  .|..:....:||..  :..||.|.|....:
plant   885 DGSEAPI-KVEAEALLASEKLVPIAVLNKI--RVPYQPIDAQLKTL------------------- 927

  Fly   907 GNKSNNGNKGKSGGSSGNRKEQTTQSTIIQTSTSKNKYYRISQQQQQKNNKQDRNGVQTQRPKAN 971
                          |:|..:..:.:..:..|.|.|.|.             :|...|:...|..|
plant   928 --------------STGRDRLLSGKQILALTLTYKFKL-------------EDSAEVKPYIPLLN 965

  Fly   972 SGEKSYDEKSRKVVGEITTNSGNGSIKAAKQVKESTTTSSNSRIPK------LFERYEKIQAIFP 1030
            :  :.||.|.......|:..  |..:.|...|     ...:|::||      |:.|:|.::.:
plant   966 N--RIYDTKFESQFFMISDT--NKRVYAMGDV-----YPESSKLPKGEYKLQLYLRHENVELL-- 1019

  Fly  1031 ELEPYENSSPKGKPKQ-----AKQGKQFEVDLFKPTNGGNSRQGNTKKS---PSV-------PP- 1079
                       .|.||     .:...:..::|....:|..:..|..|.|   |.|       ||
plant  1020 -----------EKLKQLTVFIERNMGEIRLNLHSEPDGPFTGNGAFKSSVLMPGVKEAFYLGPPT 1073

  Fly  1080 ----PSQTMATLSILPILPAGGSSFLPDQKILKKQQLLMAAAGVMAPAQVEVEMEEVHATPDYEA 1140
                |..|.....::..:..|..||  |:|..|.            |....|.....:..|..:.
plant  1074 KDKLPKNTPQGSMLVGEISYGKLSF--DEKEGKN------------PKDNPVSYPISYVVPPNKP 1124

  Fly  1141 RKDQRKEVNGPNAQITQWDMIFYGTETPAQPDDVANPSQSNQFNLYGNDMAHNDVEYDSTGQWRN 1205
            .:| :|..:.|             |.:.:..:.:....:..:....||.....:.|   ..:||.
plant  1125 EED-KKAASAP-------------TCSKSVSERLEQEVRDTKIKFLGNLKQETEEE---RSEWRK 1172

  Fly  1206 MQQVGEVGMTRDHSNTAACLK--WSD-----RKCLE-------CNDSAYMFED---------QCY 1247
            :               ..|||  :.|     .|.||       ..|.....|:         :..
plant  1173 L---------------CTCLKSEYPDYTPLLAKILEGLLSRSDAGDKISHHEEIIEAANEVVRSV 1222

  Fly  1248 DVCPVHTYPLDKFQAEEDEQDD-----EVTRGPVNPYSSSPMDHSLLMS---NSLDDKQDPLQAE 1304
            ||..:..:.|||.:.|:||.:.     ||||   :..:.:.....|.|:   |...:|:...:.|
plant  1223 DVDELARFLLDKTEPEDDEAEKLKKKMEVTR---DQLADALYQKGLAMARIENLKGEKEGEGEEE 1284

  Fly  1305 DRRRR------SSLTQLVEVPS 1320
            ..::.      ..||:.|:|.|
plant  1285 SSQKDKFEENFKELTKWVDVKS 1306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:465126	16/100 (16%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	332..621	CDD:173789	73/337 (22%)
		P_proprotein	701..787	CDD:460225	24/155 (15%)
		FU	1320..>1350	CDD:214589	1/1 (100%)
TPP2	NP_193817.2	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	116..598	CDD:173796	111/555 (20%)
		TPPII	897..1080	CDD:463636	43/252 (17%)