Protein Alignment Fur1 and furinb

DIOPT Version :10

• Sequence 1: NP_001262954.1
• Gene: Fur1 / 47220
• FlyBaseID: FBgn0004509
• Length: 1478
• Species: Drosophila melanogaster
• Sequence 2: XP_073798271.1
• Gene: furinb / 566591
• ZFINID: ZDB-GENE-040901-2
• Length: 843
• Species: Danio rerio
• Alignment Length: 622
• Identity: 336/622 - (54%)
• Similarity: 409/622 - (65%)
• Gaps: 61/622 - (9%)

  Fly   226 HIV---GHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQT 287
            |::   |.|.:||||||..|.. .|:.:|:.||||:.|::|.|:|||.|..|.:||||.......
Zfish    23 HLITGQGIYINTWAVHIEGGVE-EAERIAQKHGFVSHGQVFGDYYHFQHRGVVRRSLSSHRGVHV 86

  Fly   288 RLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLDMN 352
            ||..:.:|.||:||.||.|.||| |.|.|:                |.|:||.|||......|:|
Zfish    87 RLHTEPQVLWAEQQIAKRRRKRD-IHMEPT----------------DPKFPQQWYLYNPSHGDLN 134

  Fly   353 VIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRC 417
            |..||..|.||:||||||||||:|.||||:..||||.||||||..|.||.|.|...:.|||||||
Zfish   135 VKEAWAQGFTGRGVVVTILDDGIEKDHPDLAKNYDPDASYDVNDRDPDPQPRYTQLNDNRHGTRC 199

  Fly   418 AGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTV 482
            ||||||.|||..|.||:||.|.:||||||||:|||.|||:|||||.|||.||||||||:||||||
Zfish   200 AGEVAAAANNGVCGVGVAYNAKIGGVRMLDGEVTDVVEAQSLSLNSQHIHIYSASWGPEDDGKTV 264

  Fly   483 DGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPW 547
            |||.:||..||::|.|:||.|.||||:|||||||||:|:||||||||||:||||||.|:.|.|||
Zfish   265 DGPAKLAKEAFLQGVTEGRSGLGSIFVWASGNGGRERDSCNCDGYTNSIYTLSISSTTQYGSVPW 329

  Fly   548 YSEKCSSTLATTYSSGGQGEKQV--------------------VTTDLHHSCTVSHTGTSASAPL 592
            |||.||||||||||||...|||:                    |||||...||.|||||||||||
Zfish   330 YSEACSSTLATTYSSGNLNEKQIVCISHTFRCAFILQLYLCVQVTTDLRKKCTDSHTGTSASAPL 394

  Fly   593 AAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVA 657
            ||||.||.|::|.||||||:||:||||::||:|....|..|||||.||||:||||:||..||.:|
Zfish   395 AAGIIALALEANMNLTWRDMQHLVVRTSRPAHLITNDWRTNGVGRLVSHSYGYGLLDATAMVALA 459

  Fly   658 RNWKAVPEQQRCEINAPHVDKVIPPR---THITLQLTVNHCRS----VNYLEHVQAKITLTSQRR 715
            :||.::..|.:|.||     .:..||   :|:|...:|..|..    |:.||||||::||:...|
Zfish   460 QNWTSMGPQHKCVIN-----MLTEPRDIKSHLTFSRSVEACSGQPDFVSSLEHVQARLTLSYNHR 519

  Fly   716 GDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALL 780
            |::.:.|.||..|..|||.||..|||..|||.|.||:.|:|.|.|:|.|.|||.|......:.:|
Zfish   520 GNLAVHLISPLGTRSTLLAPRPQDNSAEGFNDWAFMTTHSWDEDPRGEWTLEIENVAGLNDYGVL 584

  Fly   781 REWSLIFYGTTQSIGPNDPISVPKPSGSEATTPNSSS 817
            .:::||.|||..        |...||.|:.|.|:::|
Zfish   585 SQFTLILYGTGS--------SATDPSVSDYTRPSNNS 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:465126	35/74 (47%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	332..621	CDD:173789	206/308 (67%)
		P_proprotein	701..787	CDD:460225	40/85 (47%)
		FU	1320..>1350	CDD:214589
furinb	XP_073798271.1	None