DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fur1 and PCSK2

DIOPT Version :10

Sequence 1:NP_001262954.1 Gene:Fur1 / 47220 FlyBaseID:FBgn0004509 Length:1478 Species:Drosophila melanogaster
Sequence 2:NP_002585.2 Gene:PCSK2 / 5126 HGNCID:8744 Length:638 Species:Homo sapiens


Alignment Length:580 Identity:271/580 - (46%)
Similarity:369/580 - (63%) Gaps:35/580 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGF-VNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDR 294
            :|:.:.|.:..|....|..||.:||| |......:..|||.|:.::|.....:.||:.:|:.|.|
Human    30 FTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPR 94

  Fly   295 VHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGG------GLDMNV 353
            |..|.||....|.||.:          |.::.:| ::.||..:.:.|||...|      |||:||
Human    95 VKMALQQEGFDRKKRGY----------RDINEID-INMNDPLFTKQWYLINTGQADGTPGLDLNV 148

  Fly   354 IPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDS--NRHGTR 416
            ..||::|.|||||.:.|:|||::..|||:..||:.:||||.:|:|..|.|.|  ||.  |.||||
Human   149 AEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRY--TDDWFNSHGTR 211

  Fly   417 CAGEVAATANNSFCAVGIAYGASVGGVRMLDGD-VTDAVEARSLSLNPQHIDIYSASWGPDDDGK 480
            |||||:|.|||:.|.||:||.:.|.|:||||.. :||.:||.|:|..||.||||||||||.|:||
Human   212 CAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGK 276

  Fly   481 TVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHV 545
            |||||.||..:|..:|..|||||||||::||||:|| ..|:||||||.:|:||:||:||..:|..
Human   277 TVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGG-SYDDCNCDGYASSMWTISINSAINDGRT 340

  Fly   546 PWYSEKCSSTLATTYSSGGQ--GEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLT 608
            ..|.|.||||||:|:|:|.:  .|..|.||||:.:||:.|:||||:||.|||:.||.|::|..||
Human   341 ALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLT 405

  Fly   609 WRDLQHIVVRTAKPANLKDP--SWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEI 671
            |||:||:.|.|:|...|.|.  .|.|||||...:|.||||::||..||::|::||.|||:..|..
Human   406 WRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVG 470

  Fly   672 NAPHVDKVIPPRTHITLQLTVNHCRS----VNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTL 732
            .:....:.||....:.|.||.:.|..    |.|||||||.||:.:.||||:.:.:.||..|...|
Human   471 GSVQDPEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSIL 535

  Fly   733 LT--PRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGT 790
            |:  || .|:|:.||::||||:.|||||..:|.|.||:...|......:|:||:|:.:||
Human   536 LSRRPR-DDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGT 594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fur1NP_001262954.1 S8_pro-domain 234..309 CDD:465126 24/75 (32%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 332..621 CDD:173789 166/299 (56%)
P_proprotein 701..787 CDD:460225 41/87 (47%)
FU 1320..>1350 CDD:214589
PCSK2NP_002585.2 S8_pro-domain 33..109 CDD:465126 24/75 (32%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 122..418 CDD:173789 166/298 (56%)
P_proprotein 504..591 CDD:460225 41/87 (47%)
Blue background indicates that the domain is not in the aligned region.

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