DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fur1 and PCSK1

DIOPT Version :10

Sequence 1:NP_001262954.1 Gene:Fur1 / 47220 FlyBaseID:FBgn0004509 Length:1478 Species:Drosophila melanogaster
Sequence 2:NP_000430.3 Gene:PCSK1 / 5122 HGNCID:8743 Length:753 Species:Homo sapiens


Alignment Length:686 Identity:316/686 - (46%)
Similarity:413/686 - (60%) Gaps:74/686 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVSKRSLSPATHHQTRLDDDD 293
            :.:.||..||.|... |.|:|::.|:..||:|  .::||.|.|....:||...|.|...||.|||
Human    31 FVNEWAAEIPGGPEA-ASAIAEELGYDLLGQIGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDD 94

  Fly   294 RVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRG------GGLDMN 352
            ||.||:||..|.||||..:|       ..|:::     |||..|.|.|||...      ..||::
Human    95 RVIWAEQQYEKERSKRSALR-------DSALNL-----FNDPMWNQQWYLQDTRMTAALPKLDLH 147

  Fly   353 VIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRC 417
            |||.|:.||||||||:|:||||||.:|.||..||||:||||.|.:|.||.|.||.|:.|:|||||
Human   148 VIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRC 212

  Fly   418 AGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTV 482
            |||:|..|||..|.||:||.:.|||:|||||.||||:||.|:..||.|:|||||||||:||||||
Human   213 AGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTV 277

  Fly   483 DGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPW 547
            :|||.||.:||..|..:||.||||||:||||||||:.|||:|||||:||:|:|||||:::|..||
Human   278 EGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPW 342

  Fly   548 YSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDL 612
            |:|||||||||:||||...::::.:.|||:.||.:||||||||||||||.||.|::|.||||||:
Human   343 YAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDM 407

  Fly   613 QHIVVRTAKPANL-KDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVA--RNWKAVPEQQRCEINAP 674
            ||:||.|::...| .:|.|.:||.|..|:..||:||::|..:|.:|  |.|::|||::.|.:.  
Human   408 QHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVK-- 470

  Fly   675 HVDKVIPPRT-----HITLQLTVNHC----RSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSV 730
              |....||.     .:.:::....|    .::..|||||.:.|:...||||:.:.|.|.|.||.
Human   471 --DNDFEPRALKANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTST 533

  Fly   731 TLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQL-------EIHNEGRYMGHALLREWSLIFY 788
            .||..|..|.|.:||..|.|||||||||:|.|.|.|       .|.||||.:      .|.||.:
Human   534 VLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIV------NWKLILH 592

  Fly   789 GTTQ--------------SIGPNDPISVPKPSGSEATTPNSSSTTSNLHQAYSPQYPRIPPNNFG 839
            ||:.              :...||...|.|........|...:...|...:.||          .
Human   593 GTSSQPEHMKQPRVYTSYNTVQNDRRGVEKMVDPGEEQPTQENPKENTLVSKSP----------S 647

  Fly   840 SSPSGGSKLPLGKVPPPNKSSYVTNNPLLNSAPPKQ 875
            ||..||.:..|.:..|......:..:....::||||
Human   648 SSSVGGRRDELEEGAPSQAMLRLLQSAFSKNSPPKQ 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fur1NP_001262954.1 S8_pro-domain 234..309 CDD:465126 34/76 (45%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 332..621 CDD:173789 190/294 (65%)
P_proprotein 701..787 CDD:460225 43/92 (47%)
FU 1320..>1350 CDD:214589
PCSK1NP_000430.3 S8_pro-domain 34..110 CDD:465126 34/76 (45%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 121..415 CDD:173789 189/293 (65%)
P_proprotein 504..591 CDD:460225 43/92 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..662 13/75 (17%)
Proho_convert 713..751 CDD:463483
Blue background indicates that the domain is not in the aligned region.

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