Protein Alignment Fur1 and FURIN

DIOPT Version :10

• Sequence 1: NP_001262954.1
• Gene: Fur1 / 47220
• FlyBaseID: FBgn0004509
• Length: 1478
• Species: Drosophila melanogaster
• Sequence 2: NP_002560.1
• Gene: FURIN / 5045
• HGNCID: 8568
• Length: 794
• Species: Homo sapiens
• Alignment Length: 647
• Identity: 343/647 - (53%)
• Similarity: 421/647 - (65%)
• Gaps: 57/647 - (8%)

  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRV 295
            :|:||||.||.|. .:|::||:.|||:|||:||.|:|||.|..|:||||||.....:||..:.:|
Human    30 FTNTWAVRIPGGP-AVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQV 93

  Fly   296 HWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLDMNVIPAWKMG 360
            .|.:||.||.|:||| :...|:                |.|:||.|||:.....|:||..||..|
Human    94 QWLEQQVAKRRTKRD-VYQEPT----------------DPKFPQQWYLSGVTQRDLNVKAAWAQG 141

  Fly   361 ITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATA 425
            .||.|:||:|||||:|.:|||:..||||.||:|||..|.||.|.|...:.|||||||||||||.|
Human   142 YTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVA 206

  Fly   426 NNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELAS 490
            ||..|.||:||.|.:||||||||:||||||||||.|||.||.||||||||:|||||||||..||.
Human   207 NNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAE 271

  Fly   491 RAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSST 555
            .||..|.::||||.||||:|||||||||.|:||||||||||:||||||||:.|:||||||.||||
Human   272 EAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSST 336

  Fly   556 LATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTA 620
            ||||||||.|.|||:|||||...||.|||||||||||||||.||.|::|:||||||:||:||:|:
Human   337 LATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTS 401

  Fly   621 KPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTH 685
            |||:|....|:.|||||:||||:||||:||..||.:|:||..|..|::|.|:.....|.|..|..
Human   402 KPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLE 466

  Fly   686 ITLQLTV-----NHCRSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGF 745
            :...:|.     ||   :..|||.||::||:..||||:.:.|.||..|..|||..|.||.|..||
Human   467 VRKTVTACLGEPNH---ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGF 528

  Fly   746 NQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGTTQSIGPNDPISVPKP---SG 807
            |.|.||:.|:|.|.|.|.|.|||.|......:..|.:::|:.|||.       |..:|.|   ||
Human   529 NDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTA-------PEGLPVPPESSG 586

  Fly   808 SEATTPNSSSTTS----NLHQAYSPQYPRIPPNNFGSSPSGGSKLPLGKVPPPNKSSYVTNN 865
            .:..|.:.:....    :|||....|:  .||               |..|....:.|.|.|
Human   587 CKTLTSSQACVVCEEGFSLHQKSCVQH--CPP---------------GFAPQVLDTHYSTEN 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:465126	39/74 (53%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	332..621	CDD:173789	204/288 (71%)
		P_proprotein	701..787	CDD:460225	40/85 (47%)
		FU	1320..>1350	CDD:214589
FURIN	NP_002560.1	S8_pro-domain	33..107	CDD:465126	39/74 (53%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	113..402	CDD:173789	205/304 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..183		12/20 (60%)
		P_proprotein	484..570	CDD:460225	40/85 (47%)
		Cell attachment site. /evidence=ECO:0000255	498..500		1/1 (100%)
		FU 1. /evidence=ECO:0000255	577..620		12/59 (20%)
		FU	581..618	CDD:214589	10/53 (19%)
		FU 2. /evidence=ECO:0000255	638..681
		FU	638..>675	CDD:214589
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	673..696
		Cell surface signal. /evidence=ECO:0000303|PubMed:9412467	759..762
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	767..794
		Trans Golgi network signal. /evidence=ECO:0000269|PubMed:8846780	773..779