Protein Alignment Fur1 and Fur2

DIOPT Version :10

• Sequence 1: NP_001262954.1
• Gene: Fur1 / 47220
• FlyBaseID: FBgn0004509
• Length: 1478
• Species: Drosophila melanogaster
• Sequence 2: NP_727963.1
• Gene: Fur2 / 32604
• FlyBaseID: FBgn0004598
• Length: 1682
• Species: Drosophila melanogaster
• Alignment Length: 1409
• Identity: 462/1409 - (32%)
• Similarity: 624/1409 - (44%)
• Gaps: 385/1409 - (27%)

  Fly   100 KSSSKSKSNR-----SRPLAKTKAVFLLALQFSAVVFLCNIN---------VGFVAGSVATAASS 150
            |.::.:|.||     ...:|::...|:|.|...:....|.:.         ||.::...||....
  Fly    74 KETATAKLNRIYLCTFNRMAQSCIYFVLFLVILSPNTSCALRSSAGETQNYVGILSNDSATTTYD 138

  Fly   151 AGGSSPAAPSSAPSSPPTVAVPPPPPPSSALKVDPNGQSPVLPPYVLDY---------------- 199
            .        ||..||..|  .||....||:..||            :||
  Fly   139 V--------SSLHSSRRT--NPPSSSSSSSSNVD------------VDYRNDRELHKVDLVGLGG 181

  Fly   200 ETGGKAKLTPNNGKFG----QSGSSGSNNNHIVGH-----------------------YTHTWAV 237
            |..|:|: |.:.||:.    .:.::.|..:.||..                       ||:.:||
  Fly   182 ERAGQAE-TISGGKYDYNYENTHTNASAKDEIVERQSNSLDFDGVDMFGAFSIPEEAIYTNEFAV 245

  Fly   238 HIPNGDNGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRVHWAKQ 300
            :||.|.. |||.:|..|||:|.|:|  .|::|.|.||.||||||..:..||..|..::.|.|.:|
  Fly   246 NIPAGKQ-MADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSENEVKWMQQ 309

  Fly   301 QRAKSRSKRD---------------------------FIRMRPSRTS----SRAMSMVDAMS--- 331
            |..|.|.|||                           .:...|...|    |:.|...|..|
  Fly   310 QHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYRDVSSHFI 374

  Fly   332 FNDSKWPQMWYL--NRGG---GLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKAS 391
            |.|..:.:.|||  ..||   ||||||.|||:.|.|||||||:|||||::::|||:..||||:||
  Fly   375 FPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPEAS 439

  Fly   392 YDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEA 456
            :|:|.:|.||.|. |..| |:|||||||||||.|.|:||.||:||.||:||||||||.|.|.|||
  Fly   440 FDINGNDSDPTPQ-DNGD-NKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGKVNDVVEA 502

  Fly   457 RSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDN 521
            ::|||||.|||||||||||:|||.||||||.||.||||.|.|.||.||||||:||||||||..|:
  Fly   503 QALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGNGGRYTDS 567

  Fly   522 CNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQG-EKQVVTTDL------HHSC 579
            ||||||||||:||||||||:.|..|||.|:||||||||||||..| :|.|.|.|:      .|.|
  Fly   568 CNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGSLRPDHIC 632

  Fly   580 TVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANL-KDPSWSRNGVGRRVSHSF 643
            ||.||||||||||||||.||.|::|..|||||:|::||.|::||.| |:..|:.|||.|:.||.|
  Fly   633 TVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTLNGVKRKYSHKF 697

  Fly   644 GYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTHITL--QLTVNHC----RSVNYLE 702
            |||||||..||.:|..|.:||.|..|:....:.|:.|......||  .:.||.|    ..|.|||
  Fly   698 GYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNGCAGTINEVRYLE 762

  Fly   703 HVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLE 767
            |||.:|||....||::::.|.||..|:.|||..|..|..:|.|:.|||:|||.|||..:|.|.|:
  Fly   763 HVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHFWGEKAEGRWTLQ 827

  Fly   768 IHNEGRYMGH--ALLREWSLIFYGTTQSIGPNDPISVPKP---SGSEATTPNSSS-----TTSNL 822
            :.|.||...:  .:|.:|.||||||:     ..|:.:...   |..:..:|:||:     :.||:
  Fly   828 VINGGRRRVNQPGILSKWQLIFYGTS-----TQPMRLKSELLNSSPQLRSPSSSNPFLFPSASNI 887

  Fly   823 HQAYSPQYPRIPPNNFGSSPSGGSKLPLGKVPPPNKSSYVTNNPLLNSAPPKQGYQQISATYGVI 887
            .|         |.|..|:.               |..|:.:   .||       ||.|.::.|
  Fly   888 GQ---------PANEGGNF---------------NTDSFAS---YLN-------YQNIFSSAG-- 916

  Fly   888 LGKANGKSNNNSKEKTNNKGNKSNNGNKGKSGGSSGNRKEQTTQSTIIQTSTSKNKYYRISQQQQ 952
                       |..:.........|.....:||||......|..:..:..:
  Fly   917 -----------SDPEPATATLDGQNVTAAIAGGSSAESLGFTASAAQLVAA-------------- 956

  Fly   953 QKNNKQDRNGVQTQRPKANSGEKSYDEKSRKVV----GEITTNS--GNGSIKAAKQVKESTTTSS 1011
                           |:...|:|       |::    .|..::.  |.|..:...........:.
  Fly   957 ---------------PETRDGDK-------KILHSCDAECDSSGCYGRGPTQCVACSHYRLDNTC 999

  Fly  1012 NSRIPKLFERYEKIQAIFPELEPYENSSPKGKPKQAKQGKQFEVDLFKPTNGGNSRQGNTKKSPS 1076
            .||.|                       |:..|.|        |.:..|.:
  Fly  1000 VSRCP-----------------------PRSFPNQ--------VGICWPCH-------------- 1019

  Fly  1077 VPPPSQTMATLSILPILPAGGSSFLPDQKILKKQQLLMAAAGVMAPAQVEVEMEEV--HATPD-- 1137
                 .|..|.:     .||..|.|                 ..|||.:.|....|  ...||
  Fly  1020 -----DTCETCA-----GAGPDSCL-----------------TCAPAHLHVIDLAVCLQFCPDGY 1057

  Fly  1138 YEARKDQRKEVNGPNAQITQWDMIFYGTETPAQPDDVANPSQSNQFNLYGNDMAHNDVEYD---- 1198
            :|..:::                    |..|.:|    |.:.......|.....|:.|.::
  Fly  1058 FENSRNR--------------------TCVPCEP----NCASCQDHPEYCTSCDHHLVMHEHKCY 1098

  Fly  1199 -----STGQWRNMQQVGEVGMTRD------HSNTAACLKWSDRKCLECNDSAYMFEDQCYDVCPV 1252
                 .|.:            |.|      ||..|.|...:|:.|:.|..|.|.::::|...||
  Fly  1099 SACPLDTYE------------TEDNKCAFCHSTCATCNGPTDQDCITCRSSRYAWQNKCLISCP- 1150

  Fly  1253 HTYPLDKFQAEEDEQDDEVTRGPVNPYSSSPMDHSLLMSNSLDDKQDP--LQAEDRRRRSSLTQL 1315
                 |.|.|::...:....:......:|:.:....|.:.:| :|:|.  :...:....|.....
  Fly  1151 -----DGFYADKKRLECMPCQEGCKTCTSNGVCSECLQNWTL-NKRDKCIVSGSEGCSESEFYSQ 1209

  Fly  1316 VEVPSRVCAACDRSCLECYGALASQCSTCSPGSQLRKILNETFC 1359
            ||   ..|..|..||..|.|...:.|::|.|    .::|.::.|
  Fly  1210 VE---GQCRPCHASCGSCNGPADTSCTSCPP----NRLLEQSRC 1246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:465126	35/76 (46%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	332..621	CDD:173789	202/300 (67%)
		P_proprotein	701..787	CDD:460225	39/87 (45%)
		FU	1320..>1350	CDD:214589	9/29 (31%)
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:465126	35/76 (46%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	375..674	CDD:173789	202/300 (67%)
		P_proprotein	761..849	CDD:460225	39/87 (45%)
		GF_recep_IV	970..1073	CDD:464344	28/198 (14%)
		VSP	1020..1379	CDD:146106	58/299 (19%)
		FU	1401..1444	CDD:214589