DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fur1 and Pcsk9

DIOPT Version :10

Sequence 1:NP_001262954.1 Gene:Fur1 / 47220 FlyBaseID:FBgn0004509 Length:1478 Species:Drosophila melanogaster
Sequence 2:NP_954862.2 Gene:Pcsk9 / 298296 RGDID:728909 Length:691 Species:Rattus norvegicus


Alignment Length:718 Identity:139/718 - (19%)
Similarity:235/718 - (32%) Gaps:251/718 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   262 IFDDHYHFA---HHKVSKRSLS-PATHHQTRLDDDDRVH----------WAKQQRAKSRSKRDFI 312
            :.|:..|.|   ..:.||.:.. |.|:....:::..|:.          ||.::....:....|.
  Rat    51 LVDEASHVATATFRRCSKEAWRLPGTYVVVLMEETQRLQVEQTAHRLQTWAARRGYVIKVLHVFY 115

  Fly   313 RMRPS---RTSSRAMSMV-----------DAMSFNDSKWPQMWYLNRGGGLDMNVIPAWKMGITG 363
            .:.|.   :.||..:.:.           |::.|..|   ..|.|.|       :||||:.....
  Rat   116 DLFPGFLVKMSSDLLGLALKLPHVEYIEEDSLVFAQS---IPWNLER-------IIPAWQQTEED 170

  Fly   364 KG------VVVTILDDGLESDHPDIQDNYDPKASYDVNS--HDDDPMPHYDMTDSNRHGTRCAGE 420
            ..      |.|.:||..::|.|.:|:...   ...|.||  .:|....|...:..:.|||..||.
  Rat   171 SSPDGSSQVEVYLLDTSIQSGHREIEGRV---TITDFNSVPEEDGTRFHRQASKCDSHGTHLAGV 232

  Fly   421 VAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGP 485
            |:..      ..|:|.|.|:..:|:|:......|....:.|     :....|       :.:...
  Rat   233 VSGR------DAGVAKGTSLHSLRVLNCQGKGTVSGTLIGL-----EFIRKS-------QLIQPS 279

  Fly   486 GELA---------SRAFIEGTTKGRGGK-GSIFIWASGNGGREQDNC-NCDGYTNSIWTLSISSA 539
            |.|.         ||  |..|...|..: |.:.:.|:||  ...|.| ........:.|:..::|
  Rat   280 GPLVVLLPLAGGYSR--ILNTACQRLARTGVVLVAAAGN--FRDDACLYSPASAPEVITVGATNA 340

  Fly   540 TEEGHVPWYSEKCSSTLATTYSSGGQ-------GEKQVVTTDLHHSCTVSHTGTSASAPLAAGIA 597
            .::          ..||.|..::.|:       |:..:..:....:|.:|.:|||.:|...|||.
  Rat   341 QDQ----------PVTLGTLGTNFGRCVDLFAPGKDIIGASSDCSTCYMSQSGTSQAAAHVAGIV 395

  Fly   598 ALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKA 662
            |::|..:..||..:|:..::                             |....:::.:|  |  
  Rat   396 AMMLNRDPALTLAELRQRLI-----------------------------LFSTKDVINMA--W-- 427

  Fly   663 VPEQQRCEINAPHVDKVIPPRTHIT-LQLTVNHCRSVNYLEHVQAKITLTS-------------- 712
            .||.||  :..|:....:||.|..| .||.   ||:| :..|.....|.|:              
  Rat   428 FPEDQR--VLTPNRVATLPPSTQETGGQLL---CRTV-WSAHSGPTRTATATARCAPEEELLSCS 486

  Fly   713 ------QRRGD---------IQLFLRSPANTSV-----TLLTPR----IHDN--SRSGFNQWPFM 751
                  :||||         :...|.:.....|     ..|.||    ||:.  :|:|    |..
  Rat   487 SFSRSGRRRGDRIEAIGGQQVCKALNAFGGEGVYAVARCCLLPRVNCSIHNTPAARAG----PQT 547

  Fly   752 SVHTWGESP-----QGNWQLE------------IHNEGRYMGH----------------ALLREW 783
            .||...:..     ..:|::|            .|..|:.:||                ..::|.
  Rat   548 PVHCHQKDHVLTGCSFHWEVENLRAQQQPLLRSRHQPGQCVGHQEASVHASCCHAPGLECKIKEH 612

  Fly   784 SLIFYGTTQSIGPNDPISVPKPSGSEATTPNSSSTTSNLHQAYSPQYPRIPPNNFGSSPSGGSKL 848
            .:        .||.:.::|...:|...|                           |.:...|:.|
  Rat   613 GI--------AGPAEQVTVACEAGWTLT---------------------------GCNVLPGASL 642

  Fly   849 PLG 851
            |||
  Rat   643 PLG 645

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fur1NP_001262954.1 S8_pro-domain 234..309 CDD:465126 10/60 (17%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 332..621 CDD:173789 70/314 (22%)
P_proprotein 701..787 CDD:460225 26/158 (16%)
FU 1320..>1350 CDD:214589
Pcsk9NP_954862.2 Inhibitor_I9 76..148 CDD:428674 9/71 (13%)
Peptidases_S8_PCSK9_ProteinaseK_like 155..420 CDD:173790 69/335 (21%)
C-terminal domain. /evidence=ECO:0000250 449..691 43/240 (18%)
PCSK9_C-CRD 451..682 CDD:421686 42/238 (18%)
Cell attachment site. /evidence=ECO:0000255 495..497 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

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