Protein Alignment Fur1 and Tpp2

DIOPT Version :10

• Sequence 1: NP_001262954.1
• Gene: Fur1 / 47220
• FlyBaseID: FBgn0004509
• Length: 1478
• Species: Drosophila melanogaster
• Sequence 2: NP_033444.1
• Gene: Tpp2 / 22019
• MGIID: 102724
• Length: 1262
• Species: Mus musculus
• Alignment Length: 747
• Identity: 145/747 - (19%)
• Similarity: 252/747 - (33%)
• Gaps: 210/747 - (28%)

  Fly   176 PPSSALKVDPNGQSPVLPPYVLD-YETGGK------AKLTPNNGK-FGQSG---SSGSNNNHIVG 229
            |.:..::|..:|:     |.::| .:|.|.      .::.|.:|: .|.||   ...:|..:.:|
Mouse    49 PGAPGMQVTTDGK-----PKIIDIIDTTGSGDVNTATEVEPKDGEIIGLSGRVLKIPANWTNPLG 108

  Fly   230 HYTHTWAVHIPNG----DNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLD 290
            .| |   :.|.||    ...:.:.:.|:    ...||:|     ..|:|   :|:.|...|...|
Mouse   109 KY-H---IGIKNGYDFYPKALKERIQKE----RKEKIWD-----PIHRV---ALAEACRKQEEFD 157

  Fly   291 DDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLDMNVIP 355
            ..:.    ...:|....|.:.            .|.|:.::..:.|     |.:.|...|..|
Mouse   158 IANN----GSSQANKLIKEEL------------QSQVELLNSFEKK-----YSDPGPVYDCLV-- 199

  Fly   356 AWKMGITGKGVVVTILDDGLESDHPDIQD-----NYD-----------PKASYDVNSHDDDPMPH 404
             |..|.|.:..|.:       :::.|:..     ||.           ...:|.||.:||..:..
Mouse   200 -WHDGETWRACVDS-------NENGDLSKCAVLRNYKEAQEYSSFGTAEMLNYSVNIYDDGNLLS 256

  Fly   405 YDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDV--------TDAVEARSLSL 461
            . :|....|||..|...|..........|:|.||.:..:::  ||.        |..:.|....:
Mouse   257 I-VTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKI--GDTRLSTMETGTGLIRAMIEVI 318

  Fly   462 NPQHIDIYSASWGP----DDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNC 522
            | ...|:.:.|:|.    .:.|:..    |:.:.|..:..|        |::.::||.|......
Mouse   319 N-HKCDLVNYSYGEATHWPNSGRIC----EVINEAVWKHNT--------IYVSSAGNNGPCLSTV 370

  Fly   523 NCDGYTNS--------------IWTLSISSATEEGHVPWYSE--KCSSTLATTYSSGGQGEKQVV 571
            .|.|.|.|              :...|:..........|.|.  .....|..:.|:.|.....|.
Mouse   371 GCPGGTTSSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVP 435

  Fly   572 TTDLHHSCTVSHTGTSASAPLAAGIAALVLQ----SNQNLTWRDLQHIVVRTAKPANLKDPSWSR 632
            ...|..  |....|||.|:|.|.|..||||.    :|.:.|...::..:..||..|:..:.....
Mouse   436 NWTLRG--TQLMNGTSMSSPNACGGIALVLSGLKANNVDYTVHSVRRALENTAIKADNIEVFAQG 498

  Fly   633 NGVGRRVSHSFGYGLMDAAEMVRV-----ARNWKAVPEQQRCEINAPH-----VDKVIPPRT--- 684
            :|: .:|..::.|.:.:.:...|:     ..|.:.:..:...::.||.     ::.|.|..|
Mouse   499 HGI-IQVDKAYDYLIQNTSFANRLGFTVTVGNNRGIYLRDPVQVAAPSDHGVGIEPVFPENTENS 562

  Fly   685 -----HITLQLTVN--------HCRSVNYLEHVQAKITLTSQRRG---------DI------QLF 721
                 .:.|.||.|        |...:|...|:..::.....|.|         ||      .||
Mouse   563 EKISFQLHLALTSNSSWVQCPSHLELMNQCRHINIRVDPRGLREGLHYTEVCGYDIASPNAGPLF 627

  Fly   722 LRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVH-----------------TWGE------SPQGN 763
             |.|.   ..::..:::::|....   .|..||                 ||.|      |.:.:
Mouse   628 -RVPI---TAVIAAKVNESSHYDL---AFTDVHFKPGQIRRHFVEVPEGATWAEVTVCSCSSEVS 685

  Fly   764 WQLEIH-----NEGRYMGHALLREWSLIFYGT 790
            .:..:|     .:..|..|...:..||...||
Mouse   686 AKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGT 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:465126	14/78 (18%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	332..621	CDD:173789	70/336 (21%)
		P_proprotein	701..787	CDD:460225	22/128 (17%)
		FU	1320..>1350	CDD:214589
Tpp2	NP_033444.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	14..489	CDD:173796	104/509 (20%)
		TPPII	777..963	CDD:463636
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1010..1030