Protein Alignment Fur1 and TppII

DIOPT Version :10

• Sequence 1: NP_001262954.1
• Gene: Fur1 / 47220
• FlyBaseID: FBgn0004509
• Length: 1478
• Species: Drosophila melanogaster
• Sequence 2: XP_314316.5
• Gene: TppII / 1275087
• VectorBaseID: AGAMI1_010323
• Length: 1421
• Species: Anopheles gambiae
• Alignment Length: 1352
• Identity: 257/1352 - (19%)
• Similarity: 431/1352 - (31%)
• Gaps: 410/1352 - (30%)

  Fly   176 PPSSALKVDPNGQSPVLPPYVL----DYETGGKAKLTPNNGKFGQSG-----SSGSNNNHIVGHY 231
            |.:..|:..|.|...|:..:..    |.:|......:|:....|.||     ||...:.::.|
Mosquito   141 PRAKGLEQIPGGDVKVIERFDCSGCGDVDTSKTVTASPDGTIVGLSGRKLHLSSTMKSKNVAG-- 203

  Fly   232 THTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRS---LSPATHHQTRLDD-- 291
                                                  :.::|..:|   |||:...:..|.|
Mosquito   204 --------------------------------------SEYRVGLKSVHDLSPSRIRERILTDLK 230

  Fly   292 ----DDRVHWAKQQRAKSRSKRDFIRMRPSR--------TSSRAMSMVDAMSFNDSKWPQMWYLN 344
                |||...|..:.|:..|  ||....||.        ......|.::.::..|.|:..:
Mosquito   231 VKTWDDRHKVAVSEAARELS--DFEAKNPSTGLTGKDKLAKENLESTLEFLNTCDKKFTDL---- 289

  Fly   345 RGGGLDMNVIP---AWKMGI--TGKGVVVTILDDG---LESDHPDIQDNYDPKASYDVNSHDDDP 401
             ....|..:.|   .|...|  |.||    .|:|.   ||........|.|...|..:|.||:..
Mosquito   290 -KTSYDCVLFPTKEGWMAVIDTTEKG----DLEDAVHVLEYTRSHQVVNLDDFLSVSINVHDEGN 349

  Fly   402 MPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGD----------VTDAVEA 456
            :.......|: |||..|...:....:.....|:|..|.:..:.:.||.          |...::.
Mosquito   350 VLEVVGVCSS-HGTHVASIASGYHPDDPELNGVAPAAKIVSLTIGDGRLESMETGTALVRAIIKV 413

  Fly   457 RSLSLNPQHIDIYSASWGP----DDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGR 517
            ..|....:.||:.:.|:|.    .:.|:..:...||.:|            .|.:::.::||.|.
Mosquito   414 MELCEAGRKIDVINMSYGEHGHWSNSGRVGELMSELVNR------------YGVVWVASAGNHGP 466

  Fly   518 -----------EQDNCNCDGYTNSIWTLSISSATEE---GHV-PWYS-EKC-SSTLATTYSSGGQ 565
                       .|.:|...|...|...:....|..:   |:| .|.| :.| ......|..:.|.
Mosquito   467 ALCTIGTPPDISQPSCVGVGAYVSPEMMEAEYALHQKLPGNVYTWSSRDPCIDGGFGVTVCAPGA 531

  Fly   566 GEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVL----QSNQNLTWRDLQHIVVRTAKPANLK 626
            ....|....:..:..::  |||.|||..||...|::    |.:...|...::..:..||...:..
Mosquito   532 AIASVPQFTMSKAQLMN--GTSMSAPHVAGSVGLLISGLKQKSIPYTAFSIKRALWNTATKIDYV 594

  Fly   627 DPSWSRNG---VGRRVSHSFGY-GLMDAAEMVRVA-----RNWKAV-------PEQQRCEIN--- 672
            |.....||   ||:...|...| ||::  ..:|.|     .|.|.:       .:.:...:|
Mosquito   595 DKFAQGNGLLNVGKAFDHLTTYCGLIE--NKLRFAVTVGNNNAKGIHMRHGVLTKVEDFSVNIEP 657

  Fly   673 -------APHVDKVIPPRTHITLQLTVNHCRSVNYLE------HVQAKITLTSQRRGDIQLFLRS 724
                   |...|| |.....:||..|.:..:..|||:      .:..|:..:....|..:..:::
Mosquito   658 VIFNEKFADAADK-INFNVRLTLIPTESWIQCGNYLDLCYSARKISVKVDPSGLAPGVYRASVKA 721

  Fly   725 PANT----------SVTLLTPRIHDNSRSGFNQ-------WPFMSVHTWGESPQ-GNWQ-LEIHN 770
            ..:.          .||::.|.:.|...:.|.:       .|...:..:...|: ..|. :|:.:
Mosquito   722 YDSACPEKGVLFEIPVTVVQPHVVDAKTNEFMRSDLPVDCKPHTIIRDFILVPKYATWAVIEMRS 786

  Fly   771 E-------GRYMGH-----------ALLREWSLIFYGTTQSIGPNDPISVPKPSGSEATTPNSSS 817
            .       |::..|           |:..:..|...||..::   .|:.|......|.......|
Mosquito   787 ADTNDAVGGKFFLHTQQILPMKFCKAMEMQKILPVNGTAPTV---QPVRVEGDHIIEICIAKFWS 848

  Fly   818 TTSNLHQAYSPQYPRIPPNNFGS---SPSGGSKLPLGKV-------------------PPPNKSS 860
            ....|...||.::..|.|.| ||   |.||..::.|..:                   |...|.:
Mosquito   849 NFGTLPLRYSIKFHGISPLN-GSVMHSASGIHRIDLTALTSEEVHPVVSLKTAAMVLKPSETKVT 912

  Fly   861 YVTNNPLLNSAPPKQGYQQISATYGVILGKANGKSNNNSKEKTNNKGNKSNNGNKGKSGGSSGNR 925
            .:|...:::  |.:|.| |:..||.:.|.|                                |..
Mosquito   913 PLTTRDVIH--PARQIY-QMQVTYHLHLTK--------------------------------GYE 942

  Fly   926 KEQTTQ--STIIQTSTSKNKYYRISQQQQQKNNKQDRNGVQTQRPKANSGEK-SYDEKSRKVVGE 987
            ....|.  |.|:..|..:::::.:               ..|.:.....|:. |||:..:...|:
Mosquito   943 VAFYTPLFSNILYESEFESQFWMV---------------YDTNKMMVRCGDAYSYDKYEKLEKGD 992

  Fly   988 ITTNSGNGSIKAAKQVKESTTTSSNSRIPKLFERYEKIQAIFPELEPYENSSPKGKPKQAKQGKQ 1052
            .|..     ::...:.||        .:.||.|....:....|     .||
Mosquito   993 YTIR-----LQVRHEKKE--------LLEKLTEANMVVNFKLP-----SNS-------------- 1025

  Fly  1053 FEVDLFKPTNGGNSRQGNTKKSPSVPPPSQTMATLSILPILPAGGSSFLPDQKILKKQQLLMAAA 1117
            ..||::|..|...|   ..||..|.     :||..|..||..|.    :|.:|:.|
Mosquito  1026 LSVDVYKSYNHVLS---GAKKMTSC-----SMAAGSCRPIYLAP----IPSEKLQK--------- 1069

  Fly  1118 GVMAPAQVEVEMEEVHATPDYEARKDQRKE----------VNGPNAQITQWDMIFYGTETPAQPD 1172
            ..|.|     :...:..:..| |::|..|:          ..||.|:.|        :.|.....
Mosquito  1070 AAMPP-----QCSWLEGSITY-AKEDIIKKCVSHCFQYILTEGPPAKKT--------SSTANATT 1120

  Fly  1173 DVANPSQSNQFNLYGNDMAHNDVEYDSTGQWRNMQQVGEVGMTRDHSNTAACLKWSDRKCLECND 1237
            ..||...:|..|  ||.:|:    ..|.|...|:...         :|.||.....:...::.|.
Mosquito  1121 GAANAVTNNATN--GNSVAN----AGSNGTGNNVITA---------TNGAANGSLPNGTAVKENR 1170

  Fly  1238 SAYMFEDQCYDVCPVHTYPLDKFQAEEDEQDDEVTRGPVNPYSSSPMDH------SLLMS---NS 1293
            |.:  ::.|..:....|..:.|..||..|          |.|.:...|:      .|.|:   :|
Mosquito  1171 SKW--DEYCEGLRDYQTAQISKLDAENAE----------NVYQALLKDNPNHLAAHLAMADHFDS 1223

  Fly  1294 LDDKQD-------PLQAEDRRR----RSSLTQLVEVPSRVCAACDRSCLECY 1334
            .|.||:       ...|.|...    :..|.:::|:.|.|....|:|.|..|
Mosquito  1224 TDLKQNLPYTFTASFDAADSSAATLLKVKLLRIIELASLVVKDIDQSALLAY 1275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:465126	13/83 (16%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	332..621	CDD:173789	68/331 (21%)
		P_proprotein	701..787	CDD:460225	16/128 (13%)
		FU	1320..>1350	CDD:214589	6/15 (40%)
TppII	XP_314316.5	None