DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fur1 and Pcsk9

DIOPT Version :10

Sequence 1:NP_001262954.1 Gene:Fur1 / 47220 FlyBaseID:FBgn0004509 Length:1478 Species:Drosophila melanogaster
Sequence 2:NP_705793.1 Gene:Pcsk9 / 100102 MGIID:2140260 Length:694 Species:Mus musculus


Alignment Length:602 Identity:122/602 - (20%)
Similarity:206/602 - (34%) Gaps:189/602 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   190 PVLPPYVLDYETGGKAKLTPNNGKFGQSGSSGSNNNHIVGHYTHTWAVHIPNGDNGMADAVAKDH 254
            |:|||.:|..     ..|.|       :|:...:.:   |.|... .:.:|:.::|:||..|   
Mouse    15 PLLPPLLLLL-----LLLCP-------TGAGAQDED---GDYEEL-MLALPSQEDGLADEAA--- 60

  Fly   255 GFVNLGKIFDDHYHFA---HHKVSKRSLS-PATHHQTRLDDDDRVHWAK-QQRAKSRSKRD---- 310
                         |.|   ..:.||.:.. |.|:....:::..|:...: ..|.::|:.|.    
Mouse    61 -------------HVATATFRRCSKEAWRLPGTYIVVLMEETQRLQIEQTAHRLQTRAARRGYVI 112

  Fly   311 -----FIRMRPS---RTSSRAMSMV-----------DAMSFNDSKWPQMWYLNRGGGLDMNVIPA 356
                 |..:.|.   :.||..:.:.           |:..|..|   ..|.|.|       :|||
Mouse   113 KVLHIFYDLFPGFLVKMSSDLLGLALKLPHVEYIEEDSFVFAQS---IPWNLER-------IIPA 167

  Fly   357 WKMGITGKG------VVVTILDDGLESDHPDIQDNYDPKASYDVNS--HDDDPMPHYDMTDSNRH 413
            |......:.      |.|.:||..::..|.:|:...   ...|.||  .:|....|...:..:.|
Mouse   168 WHQTEEDRSPDGSSQVEVYLLDTSIQGAHREIEGRV---TITDFNSVPEEDGTRFHRQASKCDSH 229

  Fly   414 GTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDD 478
            ||..||.|:..      ..|:|.|.|:..:|:|:......|....:.|     :....|      
Mouse   230 GTHLAGVVSGR------DAGVAKGTSLHSLRVLNCQGKGTVSGTLIGL-----EFIRKS------ 277

  Fly   479 GKTVDGPGELA---------SRAFIEGTTKGRGGKGSIFIWASGNGGREQDNC-NCDGYTNSIWT 533
             :.:...|.|.         || .:....:.....|.:.:.|:||  ...|.| ........:.|
Mouse   278 -QLIQPSGPLVVLLPLAGGYSR-ILNAACRHLARTGVVLVAAAGN--FRDDACLYSPASAPEVIT 338

  Fly   534 LSISSATEEGHVPWYSEKCSSTLATTYSSGGQ-------GEKQVVTTDLHHSCTVSHTGTSASAP 591
            :..::|.::          ..||.|..::.|:       |:..:..:....:|.:|.:|||.:|.
Mouse   339 VGATNAQDQ----------PVTLGTLGTNFGRCVDLFAPGKDIIGASSDCSTCFMSQSGTSQAAA 393

  Fly   592 LAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRV 656
            ..|||.|.:|.....||..:|:                       :|:.|   :...|...|.  
Mouse   394 HVAGIVARMLSREPTLTLAELR-----------------------QRLIH---FSTKDVINMA-- 430

  Fly   657 ARNWKAVPEQQRCEINAPHVDKVIPPRTHIT-LQLTVNHCRSVNYLEHVQAKITLTS-------- 712
               |  .||.|  ::..|::...:||.||.| .||.   ||:| :..|.....|.|:        
Mouse   431 ---W--FPEDQ--QVLTPNLVATLPPSTHETGGQLL---CRTV-WSAHSGPTRTATATARCAPEE 484

  Fly   713 ------------QRRGD 717
                        :||||
Mouse   485 ELLSCSSFSRSGRRRGD 501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fur1NP_001262954.1 S8_pro-domain 234..309 CDD:465126 14/79 (18%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 332..621 CDD:173789 66/313 (21%)
P_proprotein 701..787 CDD:460225 7/37 (19%)
FU 1320..>1350 CDD:214589
Pcsk9NP_705793.1 Inhibitor_I9 80..152 CDD:428674 10/71 (14%)
Peptidases_S8_PCSK9_ProteinaseK_like 159..424 CDD:173790 66/331 (20%)
C-terminal domain. /evidence=ECO:0000250 453..694 13/53 (25%)
PCSK9_C-CRD 455..686 CDD:421686 12/51 (24%)
Cell attachment site. /evidence=ECO:0000255 499..501 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

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