Protein Alignment PolZ1 and POL1

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: NP_014297.3
• Gene: POL1 / 855621
• SGDID: S000005046
• Length: 1468
• Species: Saccharomyces cerevisiae
• Alignment Length: 1691
• Identity: 332/1691 - (19%)
• Similarity: 581/1691 - (34%)
• Gaps: 523/1691 - (30%)

  Fly   603 SSSSKK--------------SNDEFAGRPSN-PRLSLQLDQGTGTGTLRPEISLRKKLAMSEMRR 652
            ||.|:|              |.|::.|..|: .|:..::|:        .|...||       |:
Yeast     2 SSKSEKLEKLRKLQAARNGTSIDDYEGDESDGDRIYDEIDE--------KEYRARK-------RQ 51

  Fly   653 KSFEDSFVL-----------LKNDCTPV--RSTRRSTSNL------DKTHIICSLTPRDRNPGLS 698
            :...|.||:           ::.|...|  .|:...|.||      .|.:|     .|:::..::
Yeast    52 ELLHDDFVVDDDGVGYVDRGVEEDWREVDNSSSDEDTGNLASKDSKRKKNI-----KREKDHQIT 111

  Fly   699 DMFETEDGKQ---LPPKKVVRKTRWSTRNQDIESLPKAGCEIERPHRSEGSALDELKPRRSARHK 760
            ||..|:..|.   ...||..:|:.......||....::| |:|:|:....|.|         |..
Yeast   112 DMLRTQHSKSTLLAHAKKSQKKSIPIDNFDDILGEFESG-EVEKPNILLPSKL---------REN 166

  Fly   761 VNSANPDECSSEIQTTGPRVTTTSLDRPQKKARLSQSPKENTKTSMNGTVALEKATKDSSSNSES 825
            :||:...|..|.|:    ||...  |.....|.:|:..|.:..:|.:..:.:|.:.....|..
Yeast   167 LNSSPTSEFKSSIK----RVNGN--DESSHDAGISKKVKIDPDSSTDKYLEIESSPLKLQSRK-- 223

  Fly   826 PHQQENSVSEQIEYLESKPKKSDETARSCDEKLQRELIPQEPAGISPGDSANSTEEITFSPCHDE 890
             .:..|.|.:.::.:|:.|    ..|......||..|:...|       ||.|..        ||
Yeast   224 -LRYANDVQDLLDDVENSP----VVATKRQNVLQDTLLANPP-------SAQSLA--------DE 268

  Fly   891 AIESDTESDYIVTK--LRKTPNLKRLRWSIRSELLNKQF-------------TPSSGIRPPETET 940
            ..:.|::.|.|:.:  :|.....:|:....||......|             |||..::......
Yeast   269 EDDEDSDEDIILKRRTMRSVTTTRRVNIDSRSNPSTSPFVTAPGTPIGIKGLTPSKSLQSNTDVA 333

  Fly   941 TPQLSPKSNESNTPE--LMRSFYEHSLIVNSPSVF-------SDFLDSPEIHMDS--------PR 988
            |..::.|..:...||  ..:.|:.....||:..:.       .|...|..:.::.        ||
Yeast   334 TLAVNVKKEDVVDPETDTFQMFWLDYCEVNNTLILFGKVKLKDDNCVSAMVQINGLCRELFFLPR 398

  Fly   989 SAPPSPDSNSFVIAPLELPPSYDEVVSGSRKMDIPEYEFQKPYYSNPSDVSKVTEVGFLVLHIPG 1053
            ......|.:..:|..|......|.:.:..:||   :|.|:.|...:.||..||    .|....|.
Yeast   399 EGKTPTDIHEEIIPLLMDKYGLDNIRAKPQKM---KYSFELPDIPSESDYLKV----LLPYQTPK 456

  Fly  1054 NKLN------DCDPFQSILGNDRGLASWRRRQLIAIGGLAMLQRHRGEQKVREYFSTQQRIAIEP 1112
            :..:      ..|.|..:.|                          |...:.|.|..|.||
Yeast   457 SSRDTIPSDLSSDTFYHVFG--------------------------GNSNIFESFVIQNRI---- 491

  Fly  1113 AQLAPTWQEAKIWLKAKELLRQREEPKKSSDDIDSPIKIKRQKITMMLQAEEGDGGSGDEDAGEE 1177
              :.|.|.:.|                                            |:........
Yeast   492 --MGPCWLDIK--------------------------------------------GADFNSIRNA 510

  Fly  1178 LDCSLSLTPLSQAKDKCK-ATPTSSKARETGKSRLKRGTRLSFIGSQDEEPPSSQSSEQSVSSSA 1241
            ..|::.:     :.||.: .|||::|..                       |:.:....|:.:
Yeast   511 SHCAVEV-----SVDKPQNITPTTTKTM-----------------------PNLRCLSLSIQT-- 545

  Fly  1242 AQAELDRSSFLRQLEGSSQDRQHDLSFGLS---HATLDNTFGFKVNLENLQQAKADIDCNHLTII 1303
                         |....:::|..:|..||   :.:||:...     ||
Yeast   546 -------------LMNPKENKQEIVSITLSAYRNISLDSPIP-----EN---------------- 576

  Fly  1304 TLEVFVSTRGDLQPDPMHDEIR----CLFYAIEHSLPDEKLPSKACGYIMVNTVQDLLSEGPFHG 1364
                       ::||.:...:|    ..|.....:|..:|||.:
Yeast   577 -----------IKPDDLCTLVRPPQSTSFPLGLAALAKQKLPGR--------------------- 609

  Fly  1365 IDRDIEVQVVTSEAEAFEALLALCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNI-APLLSRVP 1428
                  |::..:|........|:.:..|.|:..|:.::    ...:|...|...:: .|..|.:.
Yeast   610 ------VRLFNNEKAMLSCFCAMLKVEDPDVIIGHRLQ----NVYLDVLAHRMHDLNIPTFSSIG 664

  Fly  1429 TQKVRDFVDE------DREQFTDLDVEMKLC-GRILLDVWRLMRSEIALTSYTFENVMYHILHKR 1486
            .:..|.:.::      :...|...|:    | ||::.|:               .|.|...|..:
Yeast   665 RRLRRTWPEKFGRGNSNMNHFFISDI----CSGRLICDI---------------ANEMGQSLTPK 710

  Fly  1487 C-PWHTAKSLTEWFGSPCTRW---IVMEY----YLERVRG-TLTLLD-------------QLDLL 1529
            | .|    .|:|.:...|.:.   :.::|    |...|.. |:.|.:             ::.||
Yeast   711 CQSW----DLSEMYQVTCEKEHKPLDIDYQNPQYQNDVNSMTMALQENITNCMISAEVSYRIQLL 771

  Fly  1530 GRTSEMAKLIGIQFYEVLSRGSQFRVESMML-RIAKPKNLVPLSPSVQARAHMR--------AP- 1584
            ..|.::..|.|..:.:.|......|.|.::| ..::...:||.....::||..:        ||
Yeast   772 TLTKQLTNLAGNAWAQTLGGTRAGRNEYILLHEFSRNGFIVPDKEGNRSRAQKQRQNEENADAPV 836

  Fly  1585 -----EYL-ALIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCLGRVEHLGGSSPFEFGAS 1643
                 :|. .|:.||:...:.:.::|:||.|||||:|..:|.||:|.....|.:
Yeast   837 NSKKAKYQGGLVFEPEKGLHKNYVLVMDFNSLYPSIIQEFNICFTTVDRNKEDI----------- 890

  Fly  1644 QLRVSRQMLQKLLEHDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKDSSALQ 1708
                          .:|.:|.|       .||.:|:|||:|..::|.|:.||:.||...|..  :
Yeast   891 --------------DELPSVPP-------SEVDQGVLPRLLANLVDRRREVKKVMKTETDPH--K 932

  Fly  1709 RI-LHSRQLGLKLMANVTY---GYTAANFSGRMPSVEVGDSVVSKGRETLERAIKLVENNEEWKV 1769
            |: ...||..|||.||..|   ||..:.|..:    .:...|.:||||.|....:|.|:   ..:
Yeast   933 RVQCDIRQQALKLTANSMYGCLGYVNSRFYAK----PLAMLVTNKGREILMNTRQLAES---MNL 990

  Fly  1770 RVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGYMY 1834
            .||||||||:.:.....|.|:|.:||....:.|.| ..:.:::.::.|::..:|..||:|...
Yeast   991 LVVYGDTDSVMIDTGCDNYADAIKIGLGFKRLVNE-RYRLLEIDIDNVFKKLLLHAKKKYAAL-- 1052

  Fly  1835 ETADQEQ-----PVYEAKGIETVRRDGCPAVAKMLEKVLRILFETQD-----------VSKIKAY 1883
             |.:.::     .|.|.||::..||:.||....:...||..:...:|           :..|:..
Yeast  1053 -TVNLDKNGNGTTVLEVKGLDMKRREFCPLSRDVSIHVLNTILSDKDPEEALQEVYDYLEDIRIK 1116

  Fly  1884 VCRQFTKLLSGRANLQDLIFAKEFRGLNGYKPTACVPALELTRKWMQKDPRHVPRRGERVPFIIV 1948
            |.....::...:.|::   .:|:.:...|.|.   :||:::..: |:|..| |.:.|..:.|:|.
Yeast  1117 VETNNIRIDKYKINMK---LSKDPKAYPGGKN---MPAVQVALR-MRKAGR-VVKAGSVITFVIT 1173

  Fly  1949 NGPPGMQLIRLVRSPHDILANEGHKINAI------------YYITKAIIPPLNRCLLLIGA-NVH 2000
            ...   ::.....:|...:|...|.:|.:            ||:.|.|..|:.|.|..|.: ||
Yeast  1174 KQD---EIDNAADTPALSVAERAHALNEVMIKSNNLIPDPQYYLEKQIFAPVERLLERIDSFNV- 1234

  Fly  2001 DWFASLPRKLLMTPAVGTANE----LAGARGAKSTISQYFSTTSCVIDCGR----QTKAGICPDC 2057
                     :.::.|:|..::    ..|.......|:......:.:.|..|    .|....||.|
Yeast  1235 ---------VRLSEALGLDSKKYFRREGGNNNGEDINNLQPLETTITDVERFKDTVTLELSCPSC 1290

  Fly  2058 LKNATTCVVVLSD------------KTARLERGYQLTRQICQACCGRL-----GSLQCDSLDCPV 2105
            .|......:|.|:            ...:|....|||.||..:....:     |.||||...|.:
Yeast  1291 DKRFPFGGIVSSNYYRVSYNGLQCKHCEQLFTPLQLTSQIEHSIRAHISLYYAGWLQCDDSTCGI 1355

  Fly  2106 L 2106
            :
Yeast  1356 V 1356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	36/240 (15%)
		POLBc_zeta	1550..2000	CDD:99917	124/498 (25%)
		zf-C4pol	2041..2107	CDD:464119	21/87 (24%)
POL1	NP_014297.3	pol2	29..1227	CDD:273159	296/1523 (19%)
		zf-DNA_Pol	1269..1463	CDD:462651	21/88 (24%)