Protein Alignment PolZ1 and REV3

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: NP_001319333.1
• Gene: REV3 / 843071
• AraportID: AT1G67500
• Length: 1915
• Species: Arabidopsis thaliana
• Alignment Length: 2249
• Identity: 657/2249 - (29%)
• Similarity: 1018/2249 - (45%)
• Gaps: 491/2249 - (21%)

  Fly     3 AAGEAIDGVYSVRLVIADFYMEKPQFGMDPCYSELRGKEIKRVPVIRVFGGNSRGQKTCMHVHGV 67
            |..::...|:|:|:|..|:||..|..|.:.|||..:|.|:..|||||::|....|||||:|:|..
plant     2 ADSQSGSNVFSLRIVSIDYYMASPIPGYNICYSSFQGSEVNEVPVIRIYGSTPAGQKTCLHIHRA 66

  Fly    68 FPYLYIPYDKKDFE---SLERGILQMAMHLDKAINISLGQGSSNAQHVFKIQLVKGIPFYGYHRV 129
            .||||||..:...|   .::...|.:::.|:||:.:. |..:|..||:...::|:...|||||..
plant    67 LPYLYIPCSEIPLEHHKGVDGSTLALSLELEKALKLK-GNAASKRQHIHDCEIVRAKKFYGYHST 130

  Fly   130 EHQFLKIYMFNPRFVRRAANLLQSGAILSKNFSPHESHVPYILQFMIDYNLYGMSYVHVPLEVLK 194
            |..|:|||:::|..|.|||:||.:||:|.|:..|:|||:|:||||::|||||||.:||:  ..:|
plant   131 EEAFVKIYLYHPPDVARAASLLLAGAVLGKSLQPYESHIPFILQFLVDYNLYGMGHVHI--SKMK 193

  Fly   195 FR---------RNHDDDVIPYANVKQAQLLDITTAKKVACSALEVDVSSNFILNRFQLVAKSKSN 250
            ||         |..|.|..|...:.:   :.||.|...|.:::...|               .|.
plant   194 FRSPVPHHFRPRRFDLDDCPGQRIDE---VAITKANSSAAASVSFPV---------------WSL 240

  Fly   251 HTNPGIEAIWNDEKLRRQKLVEKHTDAGDEEKAEAVPVLELPPTQERHQIEIAESDIFYRTALES 315
            .|.|| :.:||         :.:.:|.            .|..:|.|||..       ||   ..
plant   241 STIPG-QWMWN---------LSEESDT------------PLSQSQHRHQHH-------YR---RQ 273

  Fly   316 KLMTLEQSTLSEQTLSDQ-----TILPQATMQTTMPGTKAQKRRFNLQKLLANAVYPEECSQDQQ 375
            .|..||....|.....|.     ..:...|.:..........::|.:...|:.|    :...:..
plant   274 SLCELEGDATSSGNFPDSKFNCLCFMYDRTFELASSLVDILNQQFKMYNSLSQA----QSDTNMV 334

  Fly   376 QLLVNASFIQNHVTCG-YSSSVSLSTSKDESDDLDETVVD--------EELILSL-TQPHGAIPH 430
            |.|| |.:.:.:...| :.:.:.....|..:.|:.:|:.|        :|::..: ..|.|..|.
plant   335 QSLV-AIWEEEYERTGVHDAPIPPDPGKPSAADVLQTMSDYVGFGNMLKEMLNKVELSPPGMKPT 398

  Fly   431 DATLREEDL----ELLDALQLLEEQNESESHVDLDSSLAPLS--------QHKKFELTPELLDKE 483
            ..:....|:    |:.| ||.|.....:.|.......|:||.        ::.::..||  .|::
plant   399 AVSSAGPDMHAKPEITD-LQALNHMVGTCSEFPASEQLSPLGEKSEEASMENDEYMKTP--TDRD 460

  Fly   484 T------AATAALFD--------EDVDSDEDADQETRHDFSTVLDDVDELLLK-----LTQSQPA 529
            |      |....||.        ||::||::..:||.......|..::::|..     ::|||..
plant   461 TPAQIQDAEALGLFKWFASSQAAEDINSDDEILRETILSPLLPLASINKVLEMASTDYVSQSQKE 525

  Fly   530 ESKELKASSKLPQIDGADDR-LQRTP----IKSISSK-------SKSSPSKTPTTPIGQKSLPKS 582
            ....|.:...||....:..| |...|    :::.|.|       :...|..:.:....:.|..:.
plant   526 CQDILDSQENLPDFGSSTKRALPSNPDSQNLRTSSDKQSLEIEVASDVPDSSTSNGASENSFRRY 590

  Fly   583 PRTP-KTSAAKKYAPLALTIGSSSSKKSNDEFAGRPSNPRLSLQLDQGTGTGTLRPEISLRKKLA 646
            .::. .||...:|...:.   |.|:|.||..:...|.....:||.|..:...:.:..::......
plant   591 RKSDLHTSEVMEYKNRSF---SKSNKPSNSVWGPLPFTLTKNLQKDFDSTNASDKLGLTKISSYP 652

  Fly   647 MSEMRRKSFEDSFVLLKNDCTPVRSTRRSTSNLDKTHII--CSLTPRDRNPGLSDMFETEDGKQL 709
            |:||     .|::::      ||:..:....|....:::  |||....|...|.. .|:...:.:
plant   653 MNEM-----TDNYIV------PVKEHQADVCNTIDRNVLAGCSLRDLMRKKRLCH-GESPVSQHM 705

  Fly   710 PPKKVVRKTRWSTRNQDIESLPKAGCEIERPHRSEGSALD------------ELKPRRSARHKVN 762
            ..:| ||.:|...:|:         |.:....:.:|.||.            .|.|       ::
plant   706 KSRK-VRDSRHGEKNE---------CTLRCEAKKQGPALSAEFSEFVCGDTPNLSP-------ID 753

  Fly   763 SANPDECSSEIQTTGPRVTTTSLDRPQKKARLSQSPKENTKTSMNGTVALEKATKDSSSN---SE 824
            |.|   |...|.|....:  .|:||...|...||:..|..:...:.||...|..:...|.   |.
plant   754 SGN---CECNISTESSEL--HSVDRCSAKETASQNSDEVLRNLSSTTVPFGKDPQTVESGTLVSS 813

  Fly   825 SPHQQENSVSEQIEYLESKPKKSDETARSCDE--KLQRELIPQEPAG---ISPG--DSANSTEEI 882
            :.|     |..:|:.::...::.:.||...||  :|....:.::|..   :|.|  |||:|.|..
plant   814 NIH-----VGIEIDSVQKSGREQESTANETDETGRLICLTLSKKPPSLDCLSAGLQDSAHSHEIH 873

  Fly   883 TFSPCHDEAIESDTESDYIVTKLRKTPNLKRLRWSIRSELLNKQFTPSSGIRPPETETTPQLSPK 947
            .....||| .|.::.                          :..|.|.
plant   874 AREKQHDE-YEGNSN--------------------------DIPFFPL----------------- 894

  Fly   948 SNESNTPELMRSFYEHSLIVNSPSVFSDFLDSPEIHMDSPRSAPPSPDSNSFVIAPLELPPSYDE 1012
              |.|..|....|...||.:            |..|::.        .||.:::.|...|||.|.
plant   895 --EDNKEEKKHFFQGTSLGI------------PLHHLND--------GSNLYLLTPAFSPPSVDS 937

  Fly  1013 VVSGSRKMDIPEYEFQKPYYSNPSDVSKVTEVGFLVLHIPGNKLNDCDPFQSILGNDRGLASWRR 1077
            |:.               :.||....|.:.              ::..|.:. ..|||| ||:
plant   938 VLQ---------------WISNDKGDSNID--------------SEKQPLRD-NHNDRG-ASF-- 969

  Fly  1078 RQLIAIGGLAMLQRHRGEQKVREYFSTQQRIAIEPAQLAPTWQEAKIWLKAKELLRQREEPKKSS 1142
            ..|.:...:..:..| .||....:.:::..          .:.|::|.||          ||.:.
plant   970 TDLASASNVVSVSEH-VEQHNNLFVNSESN----------AYTESEIDLK----------PKGTF 1013

  Fly  1143 DDIDSPIKIKRQKITMMLQAEEGDGGSGDEDAGEELDCSLSLTPLSQAKDKCKATPTSSKARETG 1207
            .:::....:.::    :.|....||.||.             |||||
plant  1014 LNLNLQASVSQE----LSQISGPDGKSGP-------------TPLSQ------------------ 1043

  Fly  1208 KSRLKRGTRLSFIGSQDEEPPSSQSSEQSVSSSAAQAELDRSSFLRQLEGSSQDRQHDLSFGLSH 1272
                        :|.:|   |:|..:.|
plant  1044 ------------MGFRD---PASMGAGQ------------------------------------- 1056

  Fly  1273 ATLDNTFGFKVNLENLQQAKADIDCNHLTIITLEVFVSTRGDLQPDPMHDEIRCLFYAIEHSLPD 1337
                                      .|||:::||...:||||:|||..|.:..:...:::   |
plant  1057 --------------------------QLTILSIEVHAESRGDLRPDPRFDSVNVIALVVQN---D 1092

  Fly  1338 EKLPSKACGYIMVNTVQDLLSEGPFHGIDRDIEVQVVTSEAEAFEALLALCERWDADIYAGYEIE 1402
            :...::.  ::::.: .|.:.:....|:. ..::.|...|.:.|...:....:||.|:..|::|:
plant  1093 DSFVAEV--FVLLFS-PDSIDQRNVDGLS-GCKLSVFLEERQLFRYFIETLCKWDPDVLLGWDIQ 1153

  Fly  1403 MSSWGYVIDRAKHLCFNIAPLLSRVPTQKVRDFVDEDRE---------------QFTDLDVE--- 1449
            ..|.|::.:||..|.......:||.|:....:..|..|:               |..::.:|
plant  1154 GGSIGFLAERAAQLGIRFLNNISRTPSPTTTNNSDNKRKLGNNLLPDPLVANPAQVEEVVIEDEW 1218

  Fly  1450 -------MKLCGRILLDVWRLMRSEIALTSYTFENVMYHILHKRCPWHTAKSLTEWFGS-PC-TR 1505
                   :.:.|||:|:.|||:|.|:.|..||.|.|...:|.::.|....|.|||||.| |. .|
plant  1219 GRTHASGVHVGGRIVLNAWRLIRGEVKLNMYTIEAVSEAVLRQKVPSIPYKVLTEWFSSGPAGAR 1283

  Fly  1506 WIVMEYYLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPKNLVP 1570
            :..:||.:.|....|.::.|||::.||||:|::.||.|:.|||||||:|||||:||:|..:|.:.
plant  1284 YRCIEYVIRRANLNLEIMSQLDMINRTSELARVFGIDFFSVLSRGSQYRVESMLLRLAHTQNYLA 1348

  Fly  1571 LSPSVQARAHMRAPEYLALIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCLGRVEHLGGS 1635
            :||..|..|...|.|.:.|:|||:|.||.||:|||||||||||||||||.|||||||::.||..:
plant  1349 ISPGNQQVASQPAMECVPLVMEPESAFYDDPVIVLDFQSLYPSMIIAYNLCFSTCLGKLAHLKMN 1413

  Fly  1636 SPFEFGASQLRVSRQMLQKLLEHDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQSM-K 1699
            :   .|.|...:...:||.|   :.:..:|..|::|..|||.|||||:|.|||.||.|||::| |
plant  1414 T---LGVSSYSLDLDVLQDL---NQILQTPNSVMYVPPEVRRGILPRLLEEILSTRIMVKKAMKK 1472

  Fly  1700 LHKDSSALQRILHSRQLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSKGRETLERAIKLVENN 1764
            |....:.|.||.::|||.|||:||||||||||.||||||..|:.||:|..||.|||:||..|..|
plant  1473 LTPSEAVLHRIFNARQLALKLIANVTYGYTAAGFSGRMPCAELADSIVQCGRSTLEKAISFVNAN 1537

  Fly  1765 EEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRY 1829
            :.|..|||||||||||||:.||...|||.:|:|||.|:|||||.||.||:||||.||.|.|||||
plant  1538 DNWNARVVYGDTDSMFVLLKGRTVKEAFVVGQEIASAITEMNPHPVTLKMEKVYHPCFLLTKKRY 1602

  Fly  1830 VGYMYETADQEQPVYEAKGIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKLLSG 1894
            |||.||:.:|.:|:::||||||||||.|.||||.:|:.||:.||.:::||:|:|:.||:.::|||
plant  1603 VGYSYESPNQREPIFDAKGIETVRRDTCEAVAKTMEQSLRLFFEQKNISKVKSYLYRQWKRILSG 1667

  Fly  1895 RANLQDLIFAKEFRGLNGYK---PTACVPALELTRKWMQKDPRHVPRRGERVPFIIVNGPPGMQL 1956
            |.:|||.|||||.| |..|.   .:...||..:..|.|:.|||..||..||||:::::|.||.:|
plant  1668 RVSLQDFIFAKEVR-LGTYSTRDSSLLPPAAIVATKSMKADPRTEPRYAERVPYVVIHGEPGARL 1731

  Fly  1957 IRLVRSPHDIL-ANEGHKINAIYYITKAIIPPLNRCLLLIGANVHDWFASLPRKLLMTPAVGTAN 2020
            :.:|..|..:| .:..:::|.:|||.|.|||.|.|...|:||:::.||..:||  |...::| ..
plant  1732 VDMVVDPLVLLDVDTPYRLNDLYYINKQIIPALQRVFGLVGADLNQWFLEMPR--LTRSSLG-QR 1793

  Fly  2021 ELAGARGAKSTISQYFSTTSCVIDCGR--QTKAGICPDCLKNATTCVVVLSDKTARLERGYQLTR 2083
            .|......|:.|..::.:..|:: ||.  |..|.:|..||:|.:.....:..||::|||..|...
plant  1794 PLNSKNSHKTRIDYFYLSKHCIL-CGEVVQESAQLCNRCLQNKSAAAATIVWKTSKLEREMQHLA 1857

  Fly  2084 QICQACCGR----LGSLQCDSLDCPVLYVLEGKRRELQQ 2118
            .||:.|.|.    ...::|:||.|.|.|    :||::|:
plant  1858 TICRHCGGGDWVVQSGVKCNSLACSVFY----ERRKVQK 1892

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301	79/178 (44%)
		DNA_polB_zeta_exo	1297..1518	CDD:99821	64/247 (26%)
		POLBc_zeta	1550..2000	CDD:99917	245/454 (54%)
		zf-C4pol	2041..2107	CDD:464119	24/71 (34%)
REV3	NP_001319333.1	PTZ00166	15..>212	CDD:240301	85/199 (43%)
		POLBc	1057..1558	CDD:214691	213/513 (42%)
		POLBc_zeta	1328..1776	CDD:99917	245/454 (54%)
		zf-C4pol	1814..1887	CDD:464119	25/77 (32%)