Protein Alignment PolZ1 and Pold1

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: NP_067694.1
• Gene: Pold1 / 59294
• RGDID: 621839
• Length: 1103
• Species: Rattus norvegicus
• Alignment Length: 1044
• Identity: 274/1044 - (26%)
• Similarity: 436/1044 - (41%)
• Gaps: 186/1044 - (17%)

  Fly  1160 LQAEEGDGGSGDEDAGEELDCSLSLTPLSQAKDKC-----------------KATPTSSKARETG 1207
            ||.|.....|.|:..|:||.     .|...|.:.|                 :.|....:.....
  Rat   160 LQRELNAAISRDQRGGKELS-----GPAVLAIELCSRESMFGYHGHGPSPFLRITLALPRLMAPA 219

  Fly  1208 KSRLKRGTRLSFIGSQDEEPPSSQSSEQSVS-----------SSAAQAELDRSSFLRQLEGSSQD 1261
            :..|::|.|:..:|:     ||....|.:|.           ......||....::|:.|..:..
  Rat   220 RRLLEQGIRVPGLGT-----PSFAPYEANVDFEIRFMVDADIVGCNWLELPAGKYVRRAEKKATL 279

  Fly  1262 RQHDLSFGLSHATLDNTFGFKVNLENLQQAKADIDCNHLTIITLEVFVSTRGDLQPDPMHDE-IR 1325
            .|.::....|........|....:..|:....||:|            :.|..:.|:|..|. |:
  Rat   280 CQLEVDVLWSDVISHPPEGQWQRIAPLRVLSFDIEC------------AGRKGIFPEPERDPVIQ 332

  Fly  1326 CLFYAIEHSLPDE----KLPSKACGYIMVNTVQDLLSEGPFHGIDRDIEVQVVTSEAEAFEALLA 1386
            .....:....|:.    .|..:.|..|:                  ..:||....|.:..:|...
  Rat   333 ICSLGLRWGEPEPFLRLALTLRPCAPIL------------------GAKVQSYEREEDLLQAWAT 379

  Fly  1387 LCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRVP--TQKVRDFVDEDREQFTDLDVE 1449
            .....|.|:..||.|:.....|:|.||:.|..:..|.|.||.  ...:||...:.|:........
  Rat   380 FILAMDPDVITGYNIQNFDLPYLISRAQTLKVDRFPFLGRVTGLRSNIRDSSFQSRQVGRRDSKV 444

  Fly  1450 MKLCGRILLDVWRLMRSEIALTSYTFENVMYHIL--HKRCPWHTAKSLTE-WFGSPCTRWIVMEY 1511
            :.:.||:.:|:.:::..|..|.|||...|.:|.|  .|....|:.  :|: ..|:..||..:..|
  Rat   445 VSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQHSI--ITDLQNGNEQTRRRLAVY 507

  Fly  1512 YLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQ 1576
            .|:.....|.||::|.:|....|||::.|:....:||||.|.:|.|.:||.|..:.|  |.|.|:
  Rat   508 CLKDAFLPLRLLERLMVLVNNVEMARVTGVPLGYLLSRGQQVKVVSQLLRQAMREGL--LMPVVK 570

  Fly  1577 ARAHMRAPEYL-ALIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCL--GRVEHLGGSSPF 1638
            ...   ..:|. |.::||...:|..|:..|||.|||||:::|:|.|::|.|  |..:.||
  Rat   571 TEG---GEDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGAAQKLG----- 627

  Fly  1639 EFGASQLRVSRQMLQKLLEHDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKD 1703
                             |:.|....:|.|..|||..||:|:||::|..:|..|:..|  .:|.::
  Rat   628 -----------------LKPDEFIKTPTGDEFVKASVRKGLLPQILENLLSARKRAK--AELAQE 673

  Fly  1704 SSALQR-ILHSRQLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSKGRETLERAIKLV------ 1761
            :..|:| :|..|||.||:..|..||:|.|.. |::|.:|:..||...||:.:|:..:||
  Rat   674 TDPLRRQVLDGRQLALKVSPNSVYGFTGAQV-GKLPCLEISQSVTGFGRQMIEKTKQLVETKYTL 737

  Fly  1762 ENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTK 1826
            ||..:...:||||||||:.......:.|||..:|.|.|..|:...|.|::|:.||||.|.:|.:|
  Rat   738 ENGYDANAKVVYGDTDSVMCRFGVSSVAEAMSLGREAANWVSSHFPSPIRLEFEKVYFPYLLISK 802

  Fly  1827 KRYVGYMYETADQEQPVYEAKGIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKL 1891
            |||.|.::.:........:.||:|.||||.||.||.::...||.:...:|.....|:.....:.|
  Rat   803 KRYAGLLFSSRSDAHDRMDCKGLEAVRRDNCPLVANLVTSSLRRILVDRDPDGAVAHAKDVISDL 867

  Fly  1892 LSGRANLQDLIFAKE-------FRGLNGYKPTACVPALELTRKWMQKDPRHVPRRGERVPFIIVN 1949
            |..|.::..|:..||       :.|...:        :||..:..::||...|..|:|||::|:.
  Rat   868 LCNRIDISQLVITKELTRAAADYAGKQAH--------VELAERMRKRDPGSAPNLGDRVPYVIIG 924

  Fly  1950 GPPGMQLIRLVRSPHDILANEGHKINAIYYITKAIIPPLNR------------CLLLIGANVHDW 2002
            ...|:........|..:| .....|:..||:.:.:..||.|            .:||.|.:..
  Rat   925 AAKGVAAYMKSEDPLFVL-EHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAESVLLRGDHTR-- 986

  Fly  2003 FASLPRKLLMTPAVG-------TANELAGARGAKSTISQYFSTTSCVIDCGRQTKAGICPDCL-K 2059
                 .|.::|..||       ..|...|.|.              |||    .:..:|..|. :
  Rat   987 -----CKTVLTSKVGGLLAFTKRRNSCIGCRS--------------VID----HQGAVCKFCQPR 1028

  Fly  2060 NATTCVVVLSDKTARLERGYQLTRQICQACCGRL-GSLQCDSLDCPVLYVLEGKRRELQQIEHWN 2123
            .:......:|...|..||..:|..| ||.|.|.| ..:.|.|.|||:.|:.:..|::|:..|
  Rat  1029 ESELYQKEVSHLNALEERFSRLWTQ-CQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQE--- 1089

  Fly  2124 KLLE 2127
            :||:
  Rat  1090 RLLQ 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	50/230 (22%)
		POLBc_zeta	1550..2000	CDD:99917	148/478 (31%)
		zf-C4pol	2041..2107	CDD:464119	21/67 (31%)
Pold1	NP_067694.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		Nuclear localization signal. /evidence=ECO:0000255	4..17
		PTZ00166	80..1096	CDD:240301	274/1044 (26%)
		CysB motif	1054..1072		7/17 (41%)