Protein Alignment PolZ1 and rev3l

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: XP_068071713.1
• Gene: rev3l / 569100
• ZFINID: ZDB-GENE-050302-55
• Length: 2964
• Species: Danio rerio
• Alignment Length: 3034
• Identity: 849/3034 - (27%)
• Similarity: 1264/3034 - (41%)
• Gaps: 1001/3034 - (32%)

  Fly    11 VYSVRLVIADFYMEKPQFGMDPCYSELRGKEIKRVPVIRVFGGNSRGQKTCMHVHGVFPYLYIPY 75
            ::|||:|.||:||..|...:|.||||.|..::|:|||:|:||....|||||:|:||:|||:|:||
Zfish    12 MFSVRIVTADYYMSSPIRELDVCYSEFRESDVKKVPVVRIFGATPAGQKTCLHLHGIFPYIYVPY 76

  Fly    76 DKKDFESLERGILQMAMHLDKAINISLGQGSSNAQHVFKIQLVKGIPFYGYHRVEHQFLKIYMFN 140
            |....|: :|.:.|:|..:|:|:|||:|..|||.||:||:.||.|:||||||..|..|:||:::|
Zfish    77 DGFGQEA-DRYLRQVAYSIDRALNISMGNPSSNVQHIFKVVLVTGMPFYGYHMREKSFMKIFLYN 140

  Fly   141 PRFVRRAANLLQSGAILSKNFSPHESHVPYILQFMIDYNLYGMSYVHVPLEVLKFRRNH------ 199
            |:.|:|.:.|||:||:::|:|.|||:|:|::||..||||||||:.  :.|..:|||::.
Zfish   141 PQMVKRVSELLQAGAVMNKSFQPHEAHIPFLLQLFIDYNLYGMNM--ISLAAVKFRKSRATASEE 203

  Fly   200 -------------------------------DDDVIPYANVKQAQLLDITTAKKVACSALEVDVS 233
                                           :::.||.:       |.:...::|:...||||..
Zfish   204 EQMGGGTSPLRNACASTFNETGLRDTLCTRWEENNIPSS-------LILEEVERVSVCELEVDAV 261

  Fly   234 SNFILNRFQLVAKSKSNHTNPGIEAIWNDEKLRRQK----------------------------- 269
            :..:|||.::   ......|||::|||:|||.||::
Zfish   262 AADVLNRLEI---ENQIGRNPGLQAIWDDEKQRRRQRSESSHIDVTESQDRDLAEVAESEKIFMK 323

  Fly   270 --------------------------------------------LVEKHTDA-----GDEEKAEA 285
                                                        .|:.|.||     .|..|.:.
Zfish   324 RVKDILRENEFDMTQAGSEMDSFPDLSLYSTVLSPDRLPSIHASQVDLHQDAVKDTKRDSRKDDE 388

  Fly   286 VPV----------------LELPPT----------QERHQIEIAE-------------------- 304
            |.|                |:|..|          ||:..:::.|
Zfish   389 VAVVDEEAILSMLENSQSFLQLSQTSSQSAIFDGSQEQAMVDLLEALANDGFGDKSSKAVTQQLT 453

  Fly   305 ----------------------------------SDIFYRTALESKLMTLEQSTLSEQTLSD--- 332
                                              |||...:|.:...|...:|:..||..|.
Zfish   454 GIASCVYNSDDEEAGPELEKKESELSKIMSQRWDSDIPEPSARQRLFMKANESSSEEQQASSDEE 518

  Fly   333 ---------QTIL--PQ------ATMQTTMPGTKAQKRRF--NLQKLLA---------------- 362
                     ||.|  ||      .:..:::....:|:|.:  ...|:||
Zfish   519 GNWKGINSFQTDLSIPQLDGAADESSDSSLKEKGSQRRSYITGTDKILASRKVFANEAVRIEASS 583

  Fly   363 --NAVYPEECSQ---DQQQLLVNASFIQNHVTCGYS-------------------SSVSLSTSKD 403
              |.|...:||:   |::.|      ...|..||.|                   ||.|..|.|.
Zfish   584 SVNIVNEYKCSEQRPDREDL------ADKHSKCGESIESSNISSLKEVTPVKHPISSNSRITYKV 642

  Fly   404 ESD--DLDETVVDEELILSLTQPHGAIPHDATLREEDLELLDALQLLEEQNESE----------- 455
            :||  ||::.:.....:....:.:.:|.|...         :.|.:||:|..|.
Zfish   643 DSDHPDLEDLMFGNSKLAQSIKKYSSIKHVEK---------NTLLILEDQRSSSACYSGLTDSAT 698

  Fly   456 ------SHVDLDSSLAPLSQHKKFELTPELLDKETAATAALFDEDV--------DSDED------ 500
                  :..|..|.:....|.:..|.:|.|..:|:.......::||        |..|:
Zfish   699 KTKIVLNPSDCRSPVKVFDQTQTLEDSPALGPEESEMGQGTKEDDVGELKIRYEDYQENKADRTI 763

  Fly   501 -ADQETRHDF--STVLDD-------------VDELLLKLTQSQPAESKELKASSKLPQIDGADDR 549
             |.||..:.|  |.:|.:             :.|:...|.|.:..:|: ||.:.|.|.:    |:
Zfish   764 VAQQEAHYKFFPSVILSNCLARPIKKQAGSKIGEVSCTLDQPEQRKSR-LKLTKKKPTL----DQ 823

  Fly   550 LQRTPIKSISSKSKSSPSKTPTTPIGQKSLPKSPRTPKTSAAKKYAPLALTIGSSSSKKSNDEFA 614
            .:..|:|:.|...:..|:....||........|......           |.||........:||
Zfish   824 KRELPVKTHSPTKEEPPALLSITPGSHNQNEVSKEVDME-----------TSGSLIESSGKGDFA 877

  Fly   615 GRPSNPRLSLQLDQGTGTGTLRPEISLRKKL---------------------------AMSEMRR 652
            ..|:|...:..........|||.:   ||::                           ..|:.:|
Zfish   878 DIPTNISCTKVASLPGSKYTLRTK---RKRIYEKGDHPRSGSSKQASVHHDDPKGSDHVFSQKKR 939

  Fly   653 KSFED------SFVLL------KNDCTPVRSTRRSTSNLDKTHIICSLTPR-------------- 691
            |..:.      .::::      ||....:     |..:.|:||.:  |||.
Zfish   940 KVTKKEPPVIIKYIIINRFKGQKNMLVKI-----SKVSSDETHTV--LTPEKLAGYEQLAPLKKF 997

  Fly   692 ---------DRNPGLSDMFETEDGKQLPPKKV-------------------VRKTR--------- 719
                     ::.|.|....     |:.|.:|.                   |.:||
Zfish   998 WPKIPESTAEKYPSLEPKV-----KKCPKRKAKINPVVKRMTTFPKSKCPRVGQTRGERRAKAML 1057

  Fly   720 --------WSTRNQDIESLPKAGCEI--ERPHRSE--GSALDELKPR-----------RSARHKV 761
                    |.:.|...:......|::  :..:.||  .|..|...||           .|..|.:
Zfish  1058 PVQTLAPPWPSYNDFTDDTCTEYCDVMMKLGYLSERAPSPTDSTPPRCWSPTEHLHGSNSNDHFI 1122

  Fly   762 NSANPDEC---SSEIQTTGPR----VTTTSLDRPQKKARLSQSPKEN------------------ 801
            |..| |.|   |.|..|..|.    :..:.:.||:|.:..||..|.|
Zfish  1123 NPHN-DPCLGSSCEALTPKPSQSGLLNRSRMQRPKKTSGTSQKRKSNSLTTATNKGSLKTEDSKW 1186

  Fly   802 -------------------------TKTSMNGTVALEKATKD-------SSSNSESPHQQENSVS 834
                                     |.||..|.:..||....       .|:||:..:..:|...
Zfish  1187 KSIPAASRKHKKYCDGIERPMFVDVTSTSQKGWMRNEKQLLQRKQDHGKGSNNSQGLNSSDNLPV 1251

  Fly   835 EQI----------EYLESKPKKSDETARSC-DEKL--------------QREL------------ 862
            .|:          .:|:|.|   ::.|..| |.|.              |::|
Zfish  1252 TQLSDYLTPFQCPSFLKSNP---EDLALGCSDSKTEVHSFFDSIASNNSQKDLRIAPNSTIEKSF 1313

  Fly   863 -IPQEPA------------GISPGDSANSTEEITFSPCHD------------------------- 889
             |..:|.            |.|...|.|::::.|.:..||
Zfish  1314 SILSQPTKTVGHPCSVITYGSSNSKSKNTSQDGTKTKNHDVISVVSGHEERSGTVQQSQLPITSR 1378

  Fly   890 -----------------EAIESDTESDYIV------TKLRKTPNLKRLRWSIRSELLNK------ 925
                             ::|.|.|.|....      |.|..:.:.|.....:..|||.|
Zfish  1379 RPQARKKDTGTALLKPVDSISSPTSSTKSAAIYESNTDLTLSSDFKNREMCVLKELLQKRQLKEE 1443

  Fly   926 -QFTPSSGI-----------------RPPETETTPQLSPKS------------------------ 948
             :...|.|:                 :...|.::|...|:.
Zfish  1444 QEANKSDGLTEAVSSTSQNTDVAKRAKSKRTLSSPSRKPRGARTKVQTRCKKNKQDDQRNDCLSS 1508

  Fly   949 ------------------NESNTPEL---------------MRSFYEHSLIV------------- 967
                              .:|.:|||               ..|.|..:..|
Zfish  1509 DGSPVFFSDPGFDSCCSVEDSLSPELPDNYRFDINVIGQTEFSSLYSGNQFVLTDKILPQKFLSD 1573

  Fly   968 -------------------------------------NSPSVF---------------------- 973
                                                 .||.:|
Zfish  1574 VSQEAANALVGLGNRTQKMFDVDDDFNHGNDRNKSGALSPELFDKVSCENGRVFPNKVSLSLLDS 1638

  Fly   974 -----------------------------------------------------SDFLDSPEIHMD 985
                                                                 ||.||...:
Zfish  1639 EKIFSTNWAGSLGKIHGLSHFRDFHCEKRDVLLDPEPKSPIMSASFAYGVSPNSDLLDGSSL--- 1700

  Fly   986 SPRSAPPSPDS----------NSFVIAPLELPPSYDEVVSGSRKMDIPEYEFQKPYYSNPSDVS- 1039
            :|.|:|.|.:|          .:.::.||..||:.:|:::....:|..|...|:|:||:||||.
Zfish  1701 TPSSSPRSINSLSQLKTSRTGGTRILKPLMSPPAREEILANLMDLDFSEATKQEPFYSDPSDVPL 1765

  Fly  1040 KVTEVGFLVLHIPGNKLNDCDPFQSILGNDRGLASWRRRQLIAIGGL-------------AMLQR 1091
            |..|||...|.:...:.:....|...| :..||..|:    :|...:             :.|.:
Zfish  1766 KPREVGGRKLILETRQASRLVEFHGDL-SQNGLQFWK----VAFSAMTNQASAPTQGCKSSKLIK 1825

  Fly  1092 HRGEQKVREYFSTQQRIAIEPAQLAPTWQEAKIWLKAKE----LLRQR----------------- 1135
            ::....|     :..::.|.|.:.||:.::.::|.:||:    |.|.|
Zfish  1826 NQSPSSV-----SDPKVIILPCKCAPSREQVQLWAQAKKQYECLQRGRIQMGGHEISELKQSTCD 1885

  Fly  1136 -----------------EEPKKSSD-------DIDSPI------------------------KIK 1152
                             :.|:|:|:       |..|||                        |.|
Zfish  1886 RSTTQKTSNSLFSENHDKRPEKNSESQHNSRNDFCSPIHFSPVKAASSDSSPSSVKCVQDIDKTK 1950

  Fly  1153 RQKITMMLQAEE-------GDGGSGDEDAGE--------ELDCSLSLTPLSQAKDKCKATPT--- 1199
            ..:||....:.|       .|....|||...        .:|.:|:.|.|..|:.|...:|:
Zfish  1951 DCRITSPPNSPEISTWQDSPDEVEQDEDKENLTGGLQPLSMDQNLNETLLENAESKDHLSPSFFG 2015

  Fly  1200 -SSKARETGKSRLKRGTRLSFIGSQDEEPPSSQSSEQSVSSSAAQAELDRS----SFLRQLEGSS 1259
             .....:...|.|...|.:....|.|:|..|........:...:|....||    :.||::..|:
Zfish  2016 IKGLVSDVRCSHLLHSTPVQRRNSTDDEASSCSPVRHEDTECRSQRLHQRSNKNKNALRRVLLST 2080

  Fly  1260 QDRQHDLSFG--------LSHATLDNTFGFKVNLENLQQAKADIDCNHLTIITLEVFVSTRGDLQ 1316
            |.:...::..        :...:..|::||||:::|||:|||..:..|||::::|:...||.:|:
Zfish  2081 QVKNQLINMNVPKKENSQIEGPSFCNSYGFKVSMQNLQEAKALHEVQHLTLMSMELHARTRRNLE 2145

  Fly  1317 PDPMHDEIRCLFYAIEHS-LPDEKLPSKACGYIMVN-----TVQDLLSEGPF---HGIDRDIEVQ 1372
            |||..|.|..|||.:... |..:...::..|.|:::     :.|...|..||   .|: ..:.|.
Zfish  2146 PDPEFDPICALFYCLSSDVLLHDSGTTRIEGAIVIDKESCTSAQASRSSTPFLFRCGV-TGLPVT 2209

  Fly  1373 VVTSEAEAFEALLALCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRVPTQKVRD-FV 1436
            ....|.|.||.:..:..::|.||..|||::|.||||::.||..|..|:...|||||....:: |:
Zfish  2210 YTCDEKELFEEVSNIIRKYDPDILVGYEVQMHSWGYLLQRASTLGVNLCQQLSRVPGDSQQNHFI 2274

  Fly  1437 DEDREQFTDLDVEMKLCGRILLDVWRLMRSEIALTSYTFENVMYHILHKRCPWHTAKSLTEWFGS 1501
            .|..|...:...|:.:.|||:|::||:|::|.||.:||||||.:|:||:|.|.::.::|::||.:
Zfish  2275 PEKDEYGAETMTEIHITGRIILNIWRIMKTEAALNNYTFENVAFHLLHQRYPLYSHRTLSDWFDT 2339

  Fly  1502 PCTRWIVMEYYLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPK 1566
            ...||.||::|:.||.||:.||.|.|::|||||:|::.|||||.||:||||:||||||||:|||.
Zfish  2340 HLHRWKVMDHYVSRVCGTVQLLQQQDIIGRTSELARVFGIQFYHVLTRGSQYRVESMMLRVAKPM 2404

  Fly  1567 NLVPLSPSVQARAHMRAPEYLALIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCLGRVEH 1631
            |.:|::||.|.||..||.:.:.|:|||:||||::.:|||||||||||::||||||:|||||.:|:
Zfish  2405 NYIPVTPSTQQRAQQRAAQCIPLVMEPESRFYSNSVIVLDFQSLYPSIVIAYNYCYSTCLGHIEN 2469

  Fly  1632 LGGSSPFEFGASQLRVSRQMLQKLLEHDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQ 1696
            ||....|:||.:.|||...:|.: |.:| :||||.||.|||..||.|:|||||.|||.||.||||
Zfish  2470 LGTYDEFKFGCASLRVPPDLLYQ-LRND-ITVSPNGVAFVKSSVRRGVLPRMLEEILKTRIMVKQ 2532

  Fly  1697 SMKLHKDSSALQRILHSRQLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSKGRETLERAIKLV 1761
            |||.:::..||.|:|.:|||||||:||||:|||:||||||||.||||||:|.|.|||||||||:|
Zfish  2533 SMKAYRNDKALSRLLDARQLGLKLIANVTFGYTSANFSGRMPCVEVGDSIVHKARETLERAIKMV 2597

  Fly  1762 ENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTK 1826
            .:.::|..|||||||||||||:.|..:.:||:||.|||:|||..||:|:|||.||||.||:||||
Zfish  2598 NDTKKWGARVVYGDTDSMFVLLKGATKEQAFKIGNEIAEAVTATNPKPIKLKFEKVYLPCILQTK 2662

  Fly  1827 KRYVGYMYETADQEQPVYEAKGIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKL 1891
            |||||||||:.|||.||::|||||||||||||.|:|:||:.|::|||::|:|::|.||.||..|:
Zfish  2663 KRYVGYMYESVDQENPVFDAKGIETVRRDGCPGVSKILERSLKLLFESRDISQVKQYVQRQCVKV 2727

  Fly  1892 LSGRANLQDLIFAKEFRGLNGYKPTACVPALELTRKWMQKDPRHVPRRGERVPFIIVNGPPGMQL 1956
            :.|:|::|||.||||:||...|:|.||||||||||:.|..|.|..||.|||||::||.|.||:.|
Zfish  2728 VEGKASMQDLTFAKEYRGSGSYRPGACVPALELTRRMMAFDRRLEPRVGERVPYVIVYGSPGVPL 2792

  Fly  1957 IRLVRSPHDILANEGHKINAIYYITKAIIPPLNRCLLLIGANVHDWFASLPRKLLMTPAVGTANE 2021
            |:|||.|.::|.:...::||.|||||.|:|||.|...|||.:|..|:..|||   :..|....:.
Zfish  2793 IQLVRRPLEVLQDPSLRLNATYYITKQILPPLARIFNLIGVDVFSWYHELPR---VQRAWSFTSS 2854

  Fly  2022 LAGARGA-KSTISQYFSTTSCVIDCGRQTKAGICPDCLKNATTCVVVLSDKTARL-ERGYQLTRQ 2084
            ..|..|. |.||||||:|..|.: |...|:.|:|..| :....||.|...:..|| |.......:
Zfish  2855 GRGEEGTKKGTISQYFTTLHCPV-CDELTQLGVCARC-RAEPQCVAVHLHQDLRLWESQQDQLLK 2917

  Fly  2085 ICQACCGRL-GSLQCDSLDCPVLYVLEGKRRELQQIEHWNKLLE 2127
            ||::|.|.. ..:.|.|||||:||.|....|.|.:..:..:|:|
Zfish  2918 ICRSCSGSAERQVPCVSLDCPILYKLSRVNRNLSRGPYLRQLVE 2961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301	90/175 (51%)
		DNA_polB_zeta_exo	1297..1518	CDD:99821	83/230 (36%)
		POLBc_zeta	1550..2000	CDD:99917	282/449 (63%)
		zf-C4pol	2041..2107	CDD:464119	22/67 (33%)
rev3l	XP_068071713.1	PTZ00166	31..>193	CDD:240301	85/164 (52%)
		DUF4683	729..1110	CDD:464832	68/411 (17%)
		REV3L_RBD	1721..1743	CDD:412083	5/21 (24%)
		DNA_polB_zeta_exo	2127..2361	CDD:99821	85/234 (36%)
		POLBc_zeta	2388..2836	CDD:99917	282/449 (63%)
		zf-C4pol	2875..2942	CDD:464119	23/68 (34%)