Protein Alignment PolZ1 and POLE

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: XP_011533097.1
• Gene: POLE / 5426
• HGNCID: 9177
• Length: 2298
• Species: Homo sapiens
• Alignment Length: 1679
• Identity: 302/1679 - (17%)
• Similarity: 504/1679 - (30%)
• Gaps: 648/1679 - (38%)

  Fly   691 RDRNPGLSDMFETEDG--KQLPPKKVVRKTRWSTRNQDI----ESLPKAG-----------CEIE 738
            |..:||.......:||  ..:...|.:.:::| |...|:    |.|.:.|           .||.
Human     9 RRADPGADGEASRDDGATSSVSALKRLERSQW-TDKMDLRFGFERLKEPGEKTGWLINMHPTEIL 72

  Fly   739 RPHRSEGSALD---------------ELKP------RRSARHKVNSANPDECSSEIQTTGPRVTT 782
            ...:..|||:|               ..||      |:....:|:|.    .|.:.|....:|.|
Human    73 DEDKRLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSF----LSKKFQGKIAKVET 133

  Fly   783 T---SLDRPQKKARLSQSPKEN-TKTSMNGTVALEKATKDSSSNSESPHQQENSVSEQIEYLESK 843
            .   .||.|.....|    |.| .:.|.:....|.|..|:.|...:...:|:::.......|.|.
Human   134 VPKEDLDLPNHLVGL----KRNYIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLSSV 194

  Fly   844 PKK------SDETARSCDEKL-----QREL-IPQE------------------------PAGISP 872
            .::      .:||::...::|     .||. :|..                        |..|:.
Human   195 LQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITR 259

  Fly   873 GDSANSTEE---ITFSPCHDEAIES--------DTESD-------------YIVTKLRKTPNLKR 913
            .|......:   :.|.      ||:        |.|:|             |::|.
Human   260 RDDLVERPDPVVLAFD------IETTKLPLKFPDAETDQIMMISYMIDGQGYLITN--------- 309

  Fly   914 LRWSIRSELLNKQFTPSSGIRPPETETTPQLSP--KSNESNTPELMRSFYEHSLIVNSPSVF--- 973
             |..:..::.:.:|||.     ||.|     .|  ..||.:...|::.::|| :....|::.
Human   310 -REIVSEDIEDFEFTPK-----PEYE-----GPFCVFNEPDEAHLIQRWFEH-VQETKPTIMVTY 362

  Fly   974 -SDFLDSPE-------------------------------IHMDSPR-----SAPPSPDSNSFVI 1001
             .||.|.|.                               ||||..|     |..|....|....
Human   363 NGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAA 427

  Fly  1002 APLELPPSYDEVVSGSRKMDIPEYEFQKPYYSNPSDVSKV-TEVGFLVLHIPGNKLNDCDPFQSI 1065
            |..:|  .||                  |...:|.|:.:: ||
Human   428 AKAKL--GYD------------------PVELDPEDMCRMATE---------------------- 450

  Fly  1066 LGNDRGLASWRRRQLIAIGGLAMLQRHRGEQKVREYFSTQQRIAIEPAQL----APTWQEAKIWL 1126
              ..:.||::.....:|...|.|...|      ...|:....|.:||.::    :.|..||.:.:
Human   451 --QPQTLATYSVSDAVATYYLYMKYVH------PFIFALCTIIPMEPDEVLRKGSGTLCEALLMV 507

  Fly  1127 KA--KELL---RQREEPKKSSDDIDSPIKIKRQKITMMLQAEEGDGGSGDE-DAG---EELDCSL 1182
            :|  ..::   :|.:|..|.:||            ..:|.:|...||..:. ::|   .::.|..
Human   508 QAFHANIIFPNKQEQEFNKLTDD------------GHVLDSETYVGGHVEALESGVFRSDIPCRF 560

  Fly  1183 SLTP-----LSQAKDKCKATPTSSKARETGKSRLKRGTRLSFIGSQDEEPPSSQ-SSEQSVSSSA 1241
            .:.|     |.|..:|     |...|.|                 ::|:.|..| ::.:.|...
Human   561 RMNPAAFDFLLQRVEK-----TLRHALE-----------------EEEKVPVEQVTNFEEVCDE- 602

  Fly  1242 AQAELDRSSFLRQLEGSSQDRQHDLSFGLSHATLDNTFGFKVNLENLQQAKADIDC---NHLTII 1303
                                                   .|..|.:|:...:.|:|   .||.:.
Human   603 ---------------------------------------IKSKLASLKDVPSRIECPLIYHLDVG 628

  Fly  1304 TLEVFVSTRGDLQPDPMHDEIRCL------------------------------FYAIEHSLPDE 1338
            .:...:.....|||..|.||..|.                              ::.|:|.|..|
Human   629 AMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQRKMAWQWRGEFMPASRSEYHRIQHQLESE 693

  Fly  1339 KLPSKACGYIMVNTVQDLLSEGP---FHGIDRDIEV----------------QVVTSEAEAFEAL 1384
            |.|             .|..|||   ||.:.|:.:.                ::..::.|  |.|
Human   694 KFP-------------PLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHITKVE--ERL 743

  Fly  1385 LALCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRVPTQKVRDFVDEDREQFTDLD-- 1447
            ..:|:|.::              :.:|                   .||.|.|. |.:|..|.
Human   744 TTICQRENS--------------FYVD-------------------TVRAFRDR-RYEFKGLHKV 774

  Fly  1448 --------------VEMKLCG--RILLDVWRLMRSEIALTSYTFENVMYHILHKRCPWHT----- 1491
                          .|:|.|.  .:|.|..:|....|..:.|.:      ::.|...|::
Human   775 WKKKLSAAVEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGY------VMRKGARWYSMEMAG 833

  Fly  1492 ------------AKSLTEWFGSPCTR-----WIVMEYYLERVRGTLTLLDQLDLLGRTSEMAK-- 1537
                        |:.|.|..|.|...     |.|:......           :.:.:|:.:.|
Human   834 IVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPE-----------NFVFKTTNVKKPK 887

  Fly  1538 --------LIGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQARAHMRAPEYLALIMEPQ 1594
                    ::.|...|..: ..|::      .:|:|.:|..::.|..:........|||:|: |.
Human   888 VTISYPGAMLNIMVKEGFT-NDQYQ------ELAEPSSLTYVTRSENSIFFEVDGPYLAMIL-PA 944

  Fly  1595 SRFYADPLIVLDFQSLYPSMIIAYNYCFSTCLGRVEHLGGSSPFEFGASQLRVSRQMLQKLLEHD 1659
            |:.....|              ...|......|.:..|.|   ||            :::..|..
Human   945 SKEEGKKL--------------KKRYAVFNEDGSLAELKG---FE------------VKRRGELQ 980

  Fly  1660 LVTVSPCGV--VFVKREVRE---GILPRMLTEILDTRQMVKQSMKLHKDSSALQRILHSRQLGLK 1719
            |:.:....|  .|:|....|   |.:.::....||.......:|   .||...:.|..:|.:..|
Human   981 LIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANM---PDSELFELISENRSMSRK 1042

  Fly  1720 L-------MANVTYGYTAANFSGRMPSVEVGDS---VVSK---GRETLERAIKLV---------- 1761
            |       ..:::.....|.|.|.....:.|.|   ::|:   |....||||.|.
Human  1043 LEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRK 1107

  Fly  1762 ---------ENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVT-EMNPQPVKLKLEK 1816
                     .:.:::.:|.:. |.|....           |:|..|.|.:| ....|.||..:.:
Human  1108 HFLRKWLKSSSLQDFDIRAIL-DWDYYIE-----------RLGSAIQKIITIPAALQQVKNPVPR 1160

  Fly  1817 VYQPCMLQTKKRYVGYMYE--------TADQEQPVYEAKGIETVRRDGCP------------AVA 1861
            |..|..|..|......:|:        |.:..:.|..|:..|...|...|            ..|
Human  1161 VKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAA 1225

  Fly  1862 KMLEKVLRILFETQDVSKIKAYVCRQFTKLLSGRANLQDLIFAKEFRGLNGYKPTACVPALEL-- 1924
            .:..|..|:|:|:|:.|                    |||.....::.:.|..|.......|.
Human  1226 PVTVKRKRVLWESQEES--------------------QDLTPTVPWQEILGQPPALGTSQEEWLV 1270

  Fly  1925 -----TRKW-MQKDPRHVPRRGERV--------PFIIVNGPP---GMQLIRLVRSPHDILANEGH 1972
                 .:|| :|...|...|:.:|:        |..|.:||.   |..|.|..||..|:...
Human  1271 WLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLRRTARSILDLPWQ--- 1332

  Fly  1973 KINAIYYITKAIIPPLNRCLLLIGANVHDWFASLPRKLLMTPAVGTANELAGAR 2026
                |..|::.....|.|...|:|:::|....|:||...:...|..|.|.|..|
Human  1333 ----IVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGASYR 1382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	53/312 (17%)
		POLBc_zeta	1550..2000	CDD:99917	103/526 (20%)
		zf-C4pol	2041..2107	CDD:464119
POLE	XP_011533097.1	DNA_polB_epsilon_exo	268..471	CDD:99822	47/273 (17%)
		POLBc_epsilon	531..1153	CDD:99918	132/801 (16%)
		DUF1744	1538..1925	CDD:462493