Protein Alignment PolZ1 and POLD1

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: NP_001295561.1
• Gene: POLD1 / 5424
• HGNCID: 9175
• Length: 1133
• Species: Homo sapiens
• Alignment Length: 884
• Identity: 245/884 - (27%)
• Similarity: 387/884 - (43%)
• Gaps: 137/884 - (15%)

  Fly  1300 LTIITLEVFVSTRGDLQPDPMHDE-IRCLFYAIEHSLPDE----KLPSKACGYIMVNTVQDLLSE 1359
            |.:::.::..:.|..:.|:|..|. |:.....:....|:.    .|..:.|..|:
Human   310 LRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPCAPIL---------- 364

  Fly  1360 GPFHGIDRDIEVQVVTSEAEAFEALLALCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLL 1424
                    ..:||....|.:..:|........|.|:..||.|:.....|:|.||:.|.....|.|
Human   365 --------GAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPFL 421

  Fly  1425 SRVP--TQKVRDFVDEDREQFTDLDVEMKLCGRILLDVWRLMRSEIALTSYTFENVMYHIL--HK 1485
            .||.  ...:||...:.::........:.:.||:.:|:.:::..|..|.|||...|.:|.|  .|
Human   422 GRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQK 486

  Fly  1486 RCPWHTAKSLTE-WFGSPCTRWIVMEYYLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSR 1549
            ....|:.  :|: ..|:..||..:..|.|:.....|.||::|.:|....|||::.|:....:|||
Human   487 EDVQHSI--ITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSR 549

  Fly  1550 GSQFRVESMMLRIAKPKNLVPLSPSVQARAHMRAPEYL-ALIMEP-------------------- 1593
            |.|.:|.|.:||.|..:.|  |.|.|::..   ..:|. |.::||
Human   550 GQQVKVVSQLLRQAMHEGL--LMPVVKSEG---GEDYTGATVIEPLKGVRPQDRAGAAWELLALT 609

  Fly  1594 ------QSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCL--GRVEHLGGSSPFEFGASQLRVSRQ 1650
                  ..|:|..|:..|||.|||||:::|:|.|::|.|  |..:.||
Human   610 PGRGCSPPRYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLG----------------- 657

  Fly  1651 MLQKLLEHDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKDSSALQR-ILHSR 1714
                 |..|....:|.|..|||..||:|:||::|..:|..|:..|  .:|.|::..|:| :|..|
Human   658 -----LTEDQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAK--AELAKETDPLRRQVLDGR 715

  Fly  1715 QLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSKGRETLERAIKL------VENNEEWKVRVVY 1773
            ||.||:.||..||:|.|.. |::|.:|:..||...||:.:|:..:|      |||......:|||
Human   716 QLALKVSANSVYGFTGAQV-GKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVY 779

  Fly  1774 GDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGYMYETAD 1838
            |||||:.......:.|||..:|.|.|..|:...|.|::|:.||||.|.:|.:||||.|.::.:..
Human   780 GDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRP 844

  Fly  1839 QEQPVYEAKGIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKLLSGRANLQDLIF 1903
            ......:.||:|.||||.||.||.::...||.|...:|.....|:.....:.||..|.::..|:.
Human   845 DAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVI 909

  Fly  1904 AKEF-RGLNGYKPTACVPALELTRKWMQKDPRHVPRRGERVPFIIVNGPPGMQLIRLVRSPHDIL 1967
            .||. |..:.|.....  .:||..:..::||...|..|:|||::|::...|:........|..:|
Human   910 TKELTRAASDYAGKQA--HVELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVL 972

  Fly  1968 ANEGHKINAIYYITKAIIPPLNR------------CLLLIGANVHDWFASLPRKLLMTPAVGTAN 2020
             .....|:..||:.:.:..||.|            .:||.|.:..       .|.::|..||...
Human   973 -EHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAEAVLLRGDHTR-------CKTVLTGKVGGLL 1029

  Fly  2021 ELAGARGAKSTISQYFSTTSCVIDCGR--QTKAGICPDCL-KNATTCVVVLSDKTARLERGYQLT 2082
            ..|..|             :|.|.|..  ..:..:|..|. :.:......:|...|..||..:|.
Human  1030 AFAKRR-------------NCCIGCRTVLSHQGAVCEFCQPRESELYQKEVSHLNALEERFSRLW 1081

  Fly  2083 RQICQACCGRL-GSLQCDSLDCPVLYVLEGKRRELQQIE 2120
            .| ||.|.|.| ..:.|.|.|||:.|:.:..|::|:..|
Human  1082 TQ-CQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQE 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	49/227 (22%)
		POLBc_zeta	1550..2000	CDD:99917	153/498 (31%)
		zf-C4pol	2041..2107	CDD:464119	21/69 (30%)
POLD1	NP_001295561.1	PTZ00166	81..1126	CDD:240301	245/884 (28%)