Protein Alignment PolZ1 and PolE1

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: NP_524462.2
• Gene: PolE1 / 42758
• FlyBaseID: FBgn0264326
• Length: 2236
• Species: Drosophila melanogaster
• Alignment Length: 2165
• Identity: 408/2165 - (18%)
• Similarity: 676/2165 - (31%)
• Gaps: 842/2165 - (38%)

  Fly    69 PYLYI-PYDKKDFESLERGILQMAMHLDKAINIS---LGQGSSNAQHVFKIQLVKGIPFYGYHRV 129
            |||.| |.|.              |||:.|..:.   .|| .|..:|:.|..|  .:|.: ...:
  Fly   100 PYLLIRPEDN--------------MHLEVARFLGRKYSGQ-ISGLEHITKEDL--DLPNH-LSGL 146

  Fly   130 EHQFLKIYMFNPRF---VRR-----------------------AANLLQSG-----AILSKNFSP 163
            :.|::|:...|...   |||                       |.:|.||.     |.|.|....
  Fly   147 QQQYIKLSFLNQTAMTKVRRELMSAVKRNQERQKSNTYYMQMLATSLAQSSAGSEDATLGKRQQD 211

  Fly   164 H--------ESHVPYILQFMID--------YNLYGMSYVHVP--------------------LEV 192
            :        |..|||.::..||        ||:...|.|.:|                    :|.
  Fly   212 YMDCIVDIREHDVPYHVRVSIDLRIFCGQWYNIRCRSGVELPTITCRPDILDRPEPVVLAFDIET 276

  Fly   193 ----LKFRRNHDDDV--IPYANVKQAQLLDITTAKKVACSALEVDVSSNFILNRFQLVAKSKSNH 251
                |||.....|.|  |.|....|..|:   |.:::        :|||  ::.|:...|
  Fly   277 TKLPLKFPDAQTDQVMMISYMIDGQGYLI---TNREI--------ISSN--VDDFEYTPK----- 323

  Fly   252 TNPGIEA---IWNDEKLRRQKLVEKHTDAGDEEKAEAVPVLELPPTQERHQIEIAESDIFYRTAL 313
              |..|.   ::|:|  ...:|:::..|          .::|:.|    |.|.....|.|....:
  Fly   324 --PEFEGNFIVFNEE--NEMQLLQRFFD----------HIMEVRP----HIIVTYNGDFFDWPFV 370

  Fly   314 ESKLMTLEQSTLSE---QTLSDQTILPQATM----------QTTMP----GTKA---QKRRFNLQ 358
            |::....:.....|   ..|.|...|.:..:          .:.:|    |.||   .|.|::..
  Fly   371 ETRAAVYDLDMKQEIGFSKLRDGNYLSRPAIHMDCLCWVKRDSYLPVGSQGLKAVAKAKLRYDPV 435

  Fly   359 KLLANAVYPEECSQ---DQQQLLVNASFIQNHVTCGY-----------SSSVSLSTSKDE----- 404
            :|     .||:..:   :|.|:|.|.| :.:.|...|           :.:..:....||
  Fly   436 EL-----DPEDMCRMAVEQPQVLANYS-VSDAVATYYLYMKYVHPFIFALNTIIPMEPDEILRKG 494

  Fly   405 SDDLDETVVDEELILSLTQPHGAIPHDATLREEDLELLDALQLLEEQNESESHVD-LDSSLAPLS 468
            |..|.||      :|.:...|..|.:....:.|..:|.:...:|:.:.....||: |:|.:....
  Fly   495 SGTLCET------LLMVEAYHAQIVYPNKHQSELNKLSNEGHVLDSETYVGGHVEALESGVFRAD 553

  Fly   469 QHKKFELTPELLDKETAATAALFDEDVDSDEDADQETRHDFSTVLDDVDELLLKLTQSQPAESKE 533
            ...:|.|.|.::.:......|:....::.:|....|      .|| ::||:..::.|.
  Fly   554 IPCRFRLDPAMVKQLQEQVDAVLRHAIEVEEGIPLE------KVL-NLDEVRQEIVQG------- 604

  Fly   534 LKASSKLPQIDGADDRLQRTPIKSISSKSKSSPSKTPTTPIGQKSLPKSPRTPKTSAAKKYAPLA 598
            |:....:|      :||::..|
  Fly   605 LQGLHDIP------NRLEQPVI------------------------------------------- 620

  Fly   599 LTIGSSSSKKSNDEFAGRPSNPRLSLQLDQGTGTGTLRPEISLRKKLAMSEMRRKSFEDSFVLLK 663
                                     ..||    .|.:.|.|.|..:|..|.|          :..
  Fly   621 -------------------------YHLD----VGAMYPNIILTNRLQPSAM----------VSD 646

  Fly   664 NDCTPVRSTRRSTSNLDKTHIIC----------SLTPRDRN--PGLSDMFETEDGKQLPP----- 711
            .||        :..:.:|..:.|          .:.|..||  ..:....|||   :.||
  Fly   647 LDC--------AACDFNKPGVRCKRSMDWLWRGEMLPASRNEFQRIQQQLETE---KFPPLFPGG 700

  Fly   712 -----------------KK----VVRKTRWSTRNQDIESLPKAGCEIE-----------RPHRSE 744
                             ||    ..||....|:...:|:.....|:.|           |..|.|
  Fly   701 PQRAFHELSKEDQAAYEKKRLTDYCRKAYKKTKLTKLETRTSTICQKENSFYVDTVRAFRDRRYE 765

  Fly   745 GSALDELKPRRSARHKVNSANPDECSSEIQTT-GPRVTTTSLDRPQK-------------KARLS 795
            ...|.::     |:..||:|.....::||:.. |..|...||....|             .||..
  Fly   766 YKGLTKV-----AKASVNAAVASGDAAEIKAAKGREVLYDSLQLAHKCILNSFYGYVMRRGARWH 825

  Fly   796 QSPKENTKTSMNGTVALEKATKDSSSNSESPHQQENSVSEQIEYLE--SKPKKSDETARSCDEKL 858
            ..|       |.|.|.|..:               |.:::..|.:|  .:|.:.|.....|
  Fly   826 SMP-------MAGIVCLTGS---------------NIITKAREIIERVGRPLELDTDGIWC---- 864

  Fly   859 QRELIPQEPAGISPGDSANSTEEITFSPCHDE----------AIESDTESDYIVT----KLRKTP 909
                       |.||   :..:|.|....|::          |:.:....|:...    :|||..
  Fly   865 -----------ILPG---SFPQEFTIHTSHEKKKKINISYPNAVLNTMVKDHFTNDQYHELRKDK 915

  Fly   910 NLKRLRWSIRSELLNKQFTPSSG-----IRPPETETTPQLSPK---SNESNTPELMRSFY----- 961
            .....::.||.|  |..|....|     :.|...|...:|..:   .|...|...::.|.
  Fly   916 ENNLPKYDIRDE--NSIFFEVDGPYLAMVLPAAKEEGKKLKKRYAVFNFDGTLAELKGFEVKRRG 978

  Fly   962 EHSLIVN-SPSVFSDFLDSPEIHMDSPRSAPPSPDSNSFVIAPLELPPSYDEVVSGSRKMDIPEY 1025
            |..||.| ..|||..||                                     :||
  Fly   979 ELQLIKNFQSSVFEAFL-------------------------------------AGS-------- 998

  Fly  1026 EFQKPYYSNPSDVSKVTEVGFLVLHIPGNKLNDCDPFQSILGND--------------------R 1070
            ..::.|.|    |:||.:....||:..|:.|.|.:.|:.|..|.                    :
  Fly   999 TLEECYAS----VAKVADYWLDVLYSRGSNLPDSELFELISENKSMSKKLEEYGAQKSTSISTAK 1059

  Fly  1071 GLASWRRRQLIAIGGLA----------------------------MLQRHR----------GEQK 1097
            .||.:...|::...|||                            .::||.          |:..
  Fly  1060 RLAEFLGEQMVKDAGLACKYIISKKPEGAPVTERAIPLAIFQSEPSVRRHHLRRWLKDNTMGDAD 1124

  Fly  1098 VRE-----YF-----STQQRIAIEPAQLA-----------PTWQEAKIWLKAKELLRQR------ 1135
            :|:     |:     .|.|:|...||.|.           |.|...|: |:..::|:||
  Fly  1125 IRDVLDWNYYIERLGGTIQKIITIPAALQGLANPVPRVQHPDWLHKKM-LEKNDVLKQRRINEMF 1188

  Fly  1136 -EEPKKSSDDIDSPIKIKRQKITMMLQAEEGDGGSGDEDAGEELDCSLSLTPLSQAKDKCKATPT 1199
             ..||      ..|:..:..|:..|......|||.|  .||..:........|.:..|: :|.|.
  Fly  1189 TSRPK------PKPLATEEDKLADMEDLAGKDGGEG--AAGCPIVTKRKRIQLEEHDDE-EAQPQ 1244

  Fly  1200 SSKAR----------ETGKSRLK--RGTRLSFIGSQDEEPPSSQSSEQS-------VSSSAAQAE 1245
            ::..|          ||.|:.::  |..:..:...||:...:.|:|:::       |.::.:.|.
  Fly  1245 ATTWRQALGAPPPIGETRKTIVEWVRFQKKKWKWQQDQRQRNRQASKRTRGEDPPVVRATGSTAT 1309

  Fly  1246 LDRSSFLRQLEGSSQDRQHDL-----SFGLSHATLDNTFGFKVNLENLQQAKADIDCNHLTIITL 1305
            |  ..|||:.:.:..|:...:     ...|.|.|:....|     |.|.:.|       ||:..:
  Fly  1310 L--GGFLRRAQRTLLDQPWQIVQLVPVDDLGHFTVWALIG-----EELHKIK-------LTVPRI 1360

  Fly  1306 EVFVSTRGDLQPDP---------MHDEIRCLFYAIEHSLPDEKLPSKACGYI------------- 1348
             .:|:.|....|:.         :....|.:|....:|:|::.....:.|.:
  Fly  1361 -FYVNQRSAAPPEEGQLWRKVNRVLPRSRPVFNLYRYSVPEQLFRDNSLGMLADLATPDIEGIYE 1424

  Fly  1349 --MVNTVQDLLSEGPFHGIDRDIE---VQVVTSEAEAF--EAL----------LALCERWDADIY 1396
              |....:.|:..|...|:.|:..   .|:.|.:.|.|  |.|          ||........||
  Fly  1425 TQMTLEFRALMDMGCICGVQREEARRLAQLATKDLETFSIEQLEQRPQTQVKYLASANNRLRKIY 1489

  Fly  1397 --------AGYEIEMSSWGYVIDRAKHLCFNIAPLLSRVPTQKVRDF-VDEDR-EQFTDLDVEMK 1451
                    |..||    |..::                :|::|...| :|..| .|..::
  Fly  1490 LYQHNTPTAKKEI----WSLIL----------------MPSKKAFVFALDTVRANQMPNM----- 1529

  Fly  1452 LCGRILLDVWRLM---------RSEIALTSYTFENVMYHILHKRCPWHTAKSLTEWFGSPCTRWI 1507
               |.|....||.         :.:|.:..|||| |:..:..|:...|..::||.
  Fly  1530 ---RQLYTAERLALLKNLTAEEQDKIPVEDYTFE-VLIEVDVKQIYRHIQRALTT---------- 1580

  Fly  1508 VMEYYLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYE----------VLS------RGSQ---- 1552
                |.:..:|...|..|..|..|...:|..|.::|.:          :||      :||:
  Fly  1581 ----YKQEHQGPTILCLQTALSARKLSLAMPILLEFPQAEIHISDDASLLSGLDWQRQGSRAVIR 1641

  Fly  1553 --------------------------------FRVESMMLRIAKPKNLVPLSPSVQARAHMRAPE 1585
                                            |..:....|:.:..|.| |..|...|..:...|
  Fly  1642 HFLNLNNVLDLMLDQCRYFHVPIGNMPPDTVLFGADLFFARLLQRHNFV-LWWSASTRPDLGGRE 1705

  Fly  1586 -----YLA------LIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCLGRVEHLGGSSPFE 1639
                 .||      .:::.::.||.|..:.|...||..|.::.     ||.:..:|  |.||...
  Fly  1706 ADDSRLLAEFEESISVVQNKAGFYPDVCVELALDSLAVSALLQ-----STRIQEME--GASSAIT 1763

  Fly  1640 FGASQLRVSRQMLQKLLEHDLVTV-----------SPCGVVF-VKREVREGILPRMLT------- 1685
            |..        |.|..||..:.||           :.|...| |.|.:..|.|..:..
  Fly  1764 FDV--------MPQVSLEEMIGTVPAATLPSYDETALCSAAFRVMRSMVNGWLREVSINRNIFSD 1820

  Fly  1686 -EILDTRQMVKQSMKLHKDSSALQRILHS--RQLGLKLMA-----NVTYGYTAANFSGRMPSVEV 1742
             :|:...:.|:.|..|..| .||:|.|::  |::.|:::|     ..|..|  |:|: |:
  Fly  1821 FQIVHFYRWVRSSNALLYD-PALRRSLNNLMRKMFLRIIAEFKRLGATIIY--ADFN-RI----- 1876

  Fly  1743 GDSVVSKGRETLERAIKLVE 1762
               ::|.|::|:..|:..|:
  Fly  1877 ---ILSSGKKTVSDALGYVD 1893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301	44/201 (22%)
		DNA_polB_zeta_exo	1297..1518	CDD:99821	50/278 (18%)
		POLBc_zeta	1550..2000	CDD:99917	60/287 (21%)
		zf-C4pol	2041..2107	CDD:464119
PolE1	NP_524462.2	DNA_polB_epsilon_exo	266..469	CDD:99822	49/244 (20%)
		POLBc_epsilon	529..1154	CDD:99918	142/833 (17%)
		DUF1744	1529..1930	CDD:462493	85/416 (20%)