Protein Alignment PolZ1 and PolD1

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: NP_524099.2
• Gene: PolD1 / 39746
• FlyBaseID: FBgn0263600
• Length: 1092
• Species: Drosophila melanogaster
• Alignment Length: 996
• Identity: 271/996 - (27%)
• Similarity: 408/996 - (40%)
• Gaps: 177/996 - (17%)

  Fly  1231 QSSEQSVSSSAAQAELDRSSFLRQLEGSSQDRQHDLSFGL-----------------SHATLDNT 1278
            ::::.:|..:....||.....:....|..:.|...:|..|                 |.....:.
  Fly   157 RNNKDNVQEAVLMVELVEKLNIHGYNGDKKQRYIKISVTLPRFVAAASRLLKKEVIMSEIDFQDC 221

  Fly  1279 FGFKVNLENLQQAKADID---CNHLTIITLEVFVSTRGDLQPDPM-HDEIRCLFYAIEHSLPDEK 1339
            ..|:.|::...:...|.|   ||.:.:                || |..||     ..||.|
  Fly   222 RAFENNIDFDIRFMVDTDVVGCNWIEL----------------PMGHWRIR-----NSHSKP--- 262

  Fly  1340 LPSKACGYIMVNTVQDLL----SEG------PFHGIDRDIE----------------VQVVT--- 1375
            ||...| .|.|:...|..    .||      ||..:..|||                :|:..
  Fly   263 LPESRC-QIEVDVAFDRFISHEPEGEWSKVAPFRILSFDIECAGRKGIFPEAKIDPVIQIANMVI 326

  Fly  1376 --SEAEAFEALL-------------ALC--------ERW-------DADIYAGYEIEMSSWGYVI 1410
              .|.|.|...:             .||        ::|       |.||..||.|....:.|::
  Fly   327 RQGEREPFIRNVFTLNECAPIIGSQVLCHDKETQMLDKWSAFVREVDPDILTGYNINNFDFPYLL 391

  Fly  1411 DRAKHLCFNIAPLLSRVPTQKVRDFVDED---------RE-QFTDLDVEMKLCGRILLDVWRLMR 1465
            :||.||.......|.|:  :.:|..:.|.         || |:.:.:      ||:..|:..::.
  Fly   392 NRAAHLKVRNFEYLGRI--KNIRSVIKEQMLQSKQMGRRENQYVNFE------GRVPFDLLFVLL 448

  Fly  1466 SEIALTSYTFENVMYHILHKRCPWHTAKSLTE-WFGSPCTRWIVMEYYLERVRGTLTLLDQLDLL 1529
            .:..|.|||...|.||.|.::........:|: ..|...||..:..|.|:.....|.||::|..:
  Fly   449 RDYKLRSYTLNAVSYHFLQEQKEDVHHSIITDLQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAI 513

  Fly  1530 GRTSEMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQARAHMRAPEYLALIMEPQ 1594
            ....|||::.|:....:|:||.|.:|.|.:||.||.|..:  .||..::......|. |.::||:
  Fly   514 VNYMEMARVTGVPLESLLTRGQQIKVLSQLLRKAKTKGFI--MPSYTSQGSDEQYEG-ATVIEPK 575

  Fly  1595 SRFYADPLIVLDFQSLYPSMIIAYNYCFSTCLGRVEHLGGSSPFEFGASQLRVSRQML--QKLLE 1657
            ..:||||:..|||.|||||:::|:|.|::|.:     |||             :|:.|  |:.|:
  Fly   576 RGYYADPISTLDFASLYPSIMMAHNLCYTTLV-----LGG-------------TREKLRQQENLQ 622

  Fly  1658 HDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMA 1722
            .|.|..:|....|||.|||.|:||.:|..:|..|:..|..:|:..|... :::|..|||.||:.|
  Fly   623 DDQVERTPANNYFVKSEVRRGLLPEILESLLAARKRAKNDLKVETDPFK-RKVLDGRQLALKISA 686

  Fly  1723 NVTYGYTAANFSGRMPSVEVGDSVVSKGRETLERAIKLVE------NNEEWKVRVVYGDTDSMFV 1781
            |..||:|.|.. |::|.:|:..||.:.||..:|.....||      |..|....|:||||||:.|
  Fly   687 NSVYGFTGAQV-GKLPCLEISGSVTAYGRTMIEMTKNEVESHYTQANGYENNAVVIYGDTDSVMV 750

  Fly  1782 LVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGYMYETADQEQPVYEA 1846
            ....:....:..:|.|.|:.|:.....|:||:.||||.|.:|..||||.| :|.|........:.
  Fly   751 NFGVKTLERSMELGREAAELVSSKFVHPIKLEFEKVYYPYLLINKKRYAG-LYFTRPDTYDKMDC 814

  Fly  1847 KGIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKLLSGRANLQDLIFAKEFRGLN 1911
            |||||||||..|.||.::...|:.|...:|.....|||.:....||..|.::..|:..||....:
  Fly   815 KGIETVRRDNSPLVANLMNSCLQKLLIERDPDGAVAYVKQVIADLLCNRIDISHLVITKELAKTD 879

  Fly  1912 GYKPTACVPALELTRKWMQKDPRHVPRRGERVPFIIVNGPPGMQLIRLVRSPHDILANEGHKINA 1976
            .....|.|   ||..|..::||...|:.|:|||::|..........:....|..:|.| ...|:|
  Fly   880 YAAKQAHV---ELAAKMKKRDPGTAPKLGDRVPYVICAAAKNTPAYQKAEDPLYVLEN-SVPIDA 940

  Fly  1977 IYYITKAIIPPLNRCL-LLIGANVHDWFASLPRKLLMTPAVGTANELAGARGAKSTISQYFSTTS 2040
            .||:.:.:..||.|.. .::|.|..............|........|||....|         ||
  Fly   941 TYYLEQQLSKPLLRIFEPILGDNAESILLKGEHTRTRTVVTSKVGGLAGFMTKK---------TS 996

  Fly  2041 CVIDCGRQTKAG-----ICPDCLKNATTCVVVLSDKTARLERGYQLTRQICQACCGRL-GSLQCD 2099
            | :.|......|     :||.|....:............||..:......||.|...| ..:.|.
  Fly   997 C-LGCKSLMPKGYEQACLCPHCEPRMSELYQKEVGAKRELEETFSRLWTECQRCQESLHEEVICS 1060

  Fly  2100 SLDCPVLYVLEGKRRELQQIE 2120
            :.|||:.|:.:..|.:|...|
  Fly  1061 NRDCPIFYMRQKVRMDLDNQE 1081

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	65/291 (22%)
		POLBc_zeta	1550..2000	CDD:99917	157/458 (34%)
		zf-C4pol	2041..2107	CDD:464119	16/71 (23%)
PolD1	NP_524099.2	PTZ00166	48..1092	CDD:240301	271/996 (27%)