Protein Alignment PolZ1 and Pole

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: NP_001100622.2
• Gene: Pole / 304573
• RGDID: 1594540
• Length: 2283
• Species: Rattus norvegicus
• Alignment Length: 1621
• Identity: 299/1621 - (18%)
• Similarity: 513/1621 - (31%)
• Gaps: 543/1621 - (33%)

  Fly   691 RDRNPGLSDMFETEDG--KQLPPKKVVRKTRWSTRNQDI----ESLPKAGCEIERP------HRS 743
            |...||.......:||  ..:...|.:.:::| |...|:    |.|.:.|   ||.      |.:
  Rat     9 RHPEPGADSEGSRDDGPSSSVSALKRLERSQW-TDKMDLRFGFERLKEPG---ERTGWLINMHPT 69

  Fly   744 EGSALDELKPRRSA-----------RHKVNSANPDE----------CSSEIQTTGPRVTTTSLDR 787
            |  .|||.|...||           |.||  |.|.:          |..|:.      :..|...
  Rat    70 E--ILDEDKRLVSAVDYYFIQDDGSRFKV--ALPYKPYFYIAARKGCDREVS------SFLSKKF 124

  Fly   788 PQKKARLSQSPKEN--------------TKTSMNGTVALEKATKDSSSNSESPHQQENSVSEQIE 838
            ..|.|:|...|||:              .|.|.:....|.|..|:.|...:...:|:::..|...
  Rat   125 QGKIAKLENVPKEDLDLPNHLVGLKRSYIKLSFHTVEDLVKVRKEISPAVKKNREQDHASDEYTT 189

  Fly   839 YLESKPKKSDETARSCDEKLQRELIPQEPAGISPGDSANSTEEITFSPCHDEAIESDTESDYIVT 903
            .|.|                           |..|.|..:.||.|.....|:........:|.|.
  Rat   190 MLSS---------------------------ILQGGSLITDEEETSKKIADQLDNIVDMREYDVP 227

  Fly   904 -KLRKTPNLK---------RLRWSI-------RSELLNKQFTPSSGIRPPETETTPQLSPKSNES 951
             .:|.:.:|:         |.|.:.       |.:|:.:   |...:...:.||| :|..|..::
  Rat   228 YHIRLSIDLRIHVAHWYNVRFRGNAFPVEIARRDDLVER---PDPVVLAFDIETT-KLPLKFPDA 288

  Fly   952 NTPELMRSFY----EHSLIVNSPSVFSDFLD---SPEIHMDSPRSAPPSPDSNSFVIAPLELPPS 1009
            .|.::|...|    :..||.|...|..|..|   :|:...:.|......||.       :.|...
  Rat   289 ETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDE-------VHLIQR 346

  Fly  1010 YDEVVSGSRKMDIPEYE---FQKPYYSNPSDV---SKVTEVGF-----------LVLHIPGNKLN 1057
            :.|.:..::...:..|.   |..|:....:.:   |...|:||           ..:|:
  Rat   347 WFEHIQETKPTIMVTYNGDFFDWPFVEARAAIHGLSMYQEIGFQKDSQGEYKAPQCIHM------ 405

  Fly  1058 DC------DPFQSI------------LGND-----------------RGLASWRRRQLIAIGGLA 1087
            ||      |.:..:            ||.|                 :.||::.....:|...|.
  Rat   406 DCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLY 470

  Fly  1088 MLQRHRGEQKVREYFSTQQRIAIEPAQL----APTWQEAKIWLKA--KELL---RQREEPKKSSD 1143
            |...|      ...|:....|.:||.::    :.|..||.:.::|  ..::   :|.:|..|.:|
  Rat   471 MKYVH------PFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTD 529

  Fly  1144 DIDSPIKIKRQKITMMLQAEEGDGGSGDE-DAG---EELDCSLSLTP-----LSQAKDKCKATPT 1199
            |            ..:|.||...||..:. ::|   .::.|...:.|     |.|..:|     |
  Rat   530 D------------GHVLDAETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEK-----T 577

  Fly  1200 SSKARETGKSRLKRGTRLSFIGSQDEEPPSSQSSE-QSVSSSAAQAELDRSSFLRQLEGSSQDRQ 1263
            ...|.|                 ::|:.|..|::. |.|...
  Rat   578 MRHAIE-----------------EEEKVPVEQATNFQEVCEQ----------------------- 602

  Fly  1264 HDLSFGLSHATLDNTFGFKVNLENLQQAKADIDC---NHLTIITLEVFVSTRGDLQPDPMHDEIR 1325
                             .|..|.:|:.....|:|   .||.:..:...:.....|||..:.||..
  Rat   603 -----------------IKTKLTSLKDVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAIVDEAT 650

  Fly  1326 CL------------------------------FYAIEHSLPDEKLPSKACGYIMVNTVQDLLSEG 1360
            |.                              ::.|:|.|..||.|             .|..||
  Rat   651 CAACDFNKPGATCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFP-------------PLFPEG 702

  Fly  1361 P---FHGIDRDIEVQVVTSEAEAFE--ALLALCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNI 1420
            |   ||.:.|:        |...:|  .|...|.:      |..:|.|:.   |.:|...:|
  Rat   703 PARAFHELSRE--------EQAKYEKRRLADYCRK------AYKKIHMTK---VEERLTTIC--- 747

  Fly  1421 APLLSRVPTQKVRDFVDEDREQFTDLDVEMKLCGRILLDVWRLMRSEIALTSYTFE-------NV 1478
                     |:...|..:....|.|...|.|  |  |..||:...|.........|       .:
  Rat   748 ---------QRENSFYVDTVRAFRDRRYEFK--G--LHKVWKKKLSAAVEVGDASEVKRCKNMEI 799

  Fly  1479 MY---HILHKRCPWHTAKSLTEWFG---SPCTRWIVMEYYLERVRGTLTLLDQLDLLGRTSEMAK 1537
            :|   .:.|| |      .|..::|   ....||..||      ...:......:::.:..|:.:
  Rat   800 LYDSLQLAHK-C------ILNSFYGYVMRKGARWYSME------MAGIVCFTGANIITQARELIE 851

  Fly  1538 LIGIQFYEVLSRGSQFRVESM--MLRIAKPKNLVPLSPSV-QARAHMRAPEYLALIM-------- 1591
            .||        |..:...:.:  :|..:.|:|.|..:.:| :.:..:..|..:..||
  Rat   852 QIG--------RPLELDTDGIWCVLPNSFPENFVIKTTNVKKPKLTISYPGAMLNIMVKEGFTNH 908

  Fly  1592 ------EPQSRFY---ADPLIVLDFQSLYPSMIIAYN----------YCFSTCLGRVEHLGGSSP 1637
                  ||.|..|   ::..|..:....|.:||:..:          |......|.:..|.|
  Rat   909 QYQELTEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKG--- 970

  Fly  1638 FEFGASQLRVSRQMLQKLLEHDLVTVSPCGV--VFVKREVREGI---LPRMLTEILDTRQMVKQS 1697
            ||            :::..|..|:.:....|  .|:|....|.:   :.::....||.......:
  Rat   971 FE------------VKRRGELQLIKIFQSSVFEAFLKGSTLEEVYASVAKVADYWLDVLYSKAAN 1023

  Fly  1698 MKLHKDSSALQRILHSRQLGLKL-------MANVTYGYTAANFSGRMPSVEVGDS---VVSK--- 1749
            |   .||...:.|..:|.:..||       ..:::.....|.|.|.....:.|.|   ::|:
  Rat  1024 M---PDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPE 1085

  Fly  1750 GRETLERAIKLV-------------------ENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIG 1795
            |....||||.|.                   .:.:::.:|.:. |.|....           |:|
  Rat  1086 GSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRTIL-DWDYYIE-----------RLG 1138

  Fly  1796 EEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGYMYETADQEQPVYEAKGIETV-----RRD 1855
            ..|.|.:|      :...|::|..|.   .:.::..::::...::..:|:.|.|..:     :|.
  Rat  1139 SAIQKIIT------IPAALQQVKNPV---PRVKHPDWLHKKLLEKNDIYKQKKISELFVLEGKRQ 1194

  Fly  1856 GCPAVAKMLEKVLRILF-ETQDVSKIKAY-----VCRQFTKLLSGRANLQDLIFAKEFRGLNGYK 1914
              ..:|:..|..|.:.. :.:|....|.|     |..:..::...:...||:.....::.:.|..
  Rat  1195 --IVMAQASENSLSLCTPDMEDFGLTKPYHSTVPVATKRKRVWESQKESQDITLTVPWQEVLGQP 1257

  Fly  1915 PTACVPALEL-------TRKWMQKDPRHVPRR-------GERVPFI--IVNGPP---GMQLIRLV 1960
            |:......|.       .:||..:..:.:.||       .|.:|.:  |..||.   |..|.|..
  Rat  1258 PSLGTTQEEWLVWLQFHKKKWQLQAQQRLARRKKQRLESAEDMPRLGAIREGPATGLGSFLRRTA 1322

  Fly  1961 RSPHDILANEGHKINAIYYITKAIIPPLNRCLLLIGANVHDWFASLPRKLLMTPAVGTANE 2021
            ||..|:...       |..|::.....|.|...:||:::|....|:||...:...|..|.:
  Rat  1323 RSIMDLPWQ-------IIQISETRQAGLFRLWAIIGSDLHCIKLSIPRVFYVNQRVAKAED 1376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	54/271 (20%)
		POLBc_zeta	1550..2000	CDD:99917	97/546 (18%)
		zf-C4pol	2041..2107	CDD:464119
Pole	NP_001100622.2	DNA_polB_epsilon_exo	268..471	CDD:99822	38/216 (18%)
		POLBc_epsilon	531..1153	CDD:99918	139/786 (18%)
		DUF1744	1525..1924	CDD:462493