Protein Alignment PolZ1 and pold-1

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: NP_506017.1
• Gene: pold-1 / 179652
• WormBaseID: WBGene00008645
• Length: 1081
• Species: Caenorhabditis elegans
• Alignment Length: 1007
• Identity: 264/1007 - (26%)
• Similarity: 423/1007 - (42%)
• Gaps: 173/1007 - (17%)

  Fly  1200 SSKARETGK-------SRLKRGTRLSFIGSQDEEPPSSQSSEQSVSSSAAQAELDRSSFLRQLEG 1257
            |.:|:..||       ..:..|..|.:....|.:.|..:.|..:.:...|:.||.....|
 Worm   142 SGQAQLPGKVVDNLVHVEIVHGENLYYFRGADTKVPFVKVSGSTEALHKARMELKNGVNL----- 201

  Fly  1258 SSQDRQHDLSFGLSHATLDNTFGFKVNLENLQQAKADI-DCNHLTIITLEVFVSTRGDLQPDPMH 1321
                      .|.....:.|.:...:|:..:..||.:| .|..:.|...:..:.:..:
 Worm   202 ----------MGKGPVNVGNLYESNINVIVMFLAKTNIVGCGWIEIPAGKCRILSNSE------- 249

  Fly  1322 DEIRCLFYAIEHSLPDEKL-----PSKACGYIMVNT----VQDLLSEGPFHGIDRDIEVQV---- 1373
            ...||   .||.::|.:.|     ..:..|...:.|    ::.:...|.|....:|..:|:
 Worm   250 KSSRC---QIEVTVPVKNLIVHESDGEWAGIAPIRTLSLDIECIGRRGVFPEAIKDPIIQIANLV 311

  Fly  1374 -VTSEAEAFEA---LLALC------------------ERW-------DADIYAGYEIEMSSWGYV 1409
             :..|||.|..   :|..|                  |:|       |.||..||.|......|:
 Worm   312 KIEGEAEPFVRNCFVLGTCAPVVGSNIIQCVNEKVLLEKWAEFVREVDPDIITGYNILNFDLPYI 376

  Fly  1410 IDRAKHLCFNIAPLLSRVPTQK-----VRDFVDEDREQFTDLDVEMKLCGRILLDVWRLMRSEIA 1469
            :||||.|..   |.:|.:..||     |||.....::..:.::..:.:.|||:.||.:::..:..
 Worm   377 LDRAKVLSL---PQVSHLGRQKEKGSVVRDAAISSKQMGSRVNKSIDIHGRIIFDVLQVVLRDYK 438

  Fly  1470 LTSYTFENVMYHIL--------HKRCPWHTAKSLTEWFGSPCTRWIVMEYYLERVRGTLTLLDQL 1526
            |.|||..:|.|..|        |...|     .|..  |...||..:.:|.|:.....|.|||:|
 Worm   439 LRSYTLNSVSYQFLSEQKEDVEHNIIP-----DLQR--GDEQTRRRLAQYCLKDAYLPLRLLDKL 496

  Fly  1527 DLLGRTSEMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQARAHMRAPEYLALIM 1591
            ..:....|||::.|:....:|::|.|.::.|||||..|..|.  ..|.::|.:........|.::
 Worm   497 MSIINYIEMARVTGVPMNFLLTKGQQIKILSMMLRRCKQNNF--FLPVIEANSGDGEGYEGATVI 559

  Fly  1592 EPQSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCLGRVEHLGGSSPFEFGASQLRVSRQMLQKLL 1656
            :|...||.:|:..|||.|||||::||:|.|::|.|        .||               |.:.
 Worm   560 DPIRGFYNEPIATLDFASLYPSIMIAHNLCYTTLL--------KSP---------------QGVE 601

  Fly  1657 EHDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKDSSALQRILHS-RQLGLKL 1720
            ..|.:. :|.|..|..:..|.|:||.:|.:||..|:..|..||..||.  .:|:::: |||.||:
 Worm   602 NEDYIR-TPSGQYFATKSKRRGLLPEILEDILAARKRAKNDMKNEKDE--FKRMVYNGRQLALKI 663

  Fly  1721 MANVTYGYTAANFSGRMPSVEVGDSVVSKGRETL-------ERAIK--LVENNEEWKVRVVYGDT 1776
            .||..||:|.|.. |::|.:|:..||.:.||:.:       ||..|  .::.......:|:||||
 Worm   664 SANSVYGFTGATV-GKLPCLEISQSVTAFGRKMIDMTKLEVERIYKKGALDGKCPADAKVIYGDT 727

  Fly  1777 DSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGYMYETADQEQ 1841
            ||:.|.......|:|..||.:.||.|:::...|:||:.||||.|.:|..||||.| :|.|.....
 Worm   728 DSVMVKFGVETVAQAMEIGLDAAKEVSKIFTPPIKLEFEKVYSPYLLINKKRYAG-LYFTKPDVH 791

  Fly  1842 PVYEAKGIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKLLSGRANLQDLIFAKE 1906
            ...:.||:||||||.||.|||:|...|..|...:|......:..|..:.||..:.::..||.:||
 Worm   792 DKMDCKGLETVRRDNCPLVAKVLGVCLEKLLIERDQQSALDFAKRTISDLLCNKIDISLLIISKE 856

  Fly  1907 FRGLNGYKPTACVPALELTRKWMQKDPRHVPRRGERVPFIIVNGPPGMQLIRLVRSPHDILANEG 1971
            .. .:|.|..|....:||..:..::|....||.|:|||::.|.....:........|..:|.| .
 Worm   857 LT-KSGDKYQAKQAHVELAARMKKRDAGSAPRLGDRVPYVFVAAAKNVPAYERAEDPTFVLQN-N 919

  Fly  1972 HKINAIYYITKAIIPPLNRC-----------LLLIGANVHDWFASLPRKLLMTPAVGTA---NEL 2022
            ..::..:|:|..:..||.|.           :|:.|.:..      .|.::.:...|.|   .:.
 Worm   920 IPLDTKHYLTNQLAKPLARIFEPILGDRAEKILVEGEHTR------VRTVVQSKVGGLAAFTTKS 978

  Fly  2023 AGARGAKSTISQYFSTTSCVIDCGRQTKAGICPDCLKNATTCVVVLSDKTARLERGYQLTRQICQ 2087
            |...|.||.:.:            .:::..:|..|.....|......:....||..:......||
 Worm   979 ATCLGCKSVLPR------------AESENAVCKHCEPKLPTIFASRMNTMHELENHFGRLWTECQ 1031

  Fly  2088 ACCGRL-GSLQCDSLDCPVLYVLEGKRRELQQ 2118
            .|...: ..:.|.:.|||:.|:.|..|.||.:
 Worm  1032 NCAKTMQDKVNCSARDCPIYYMREKVRNELSE 1063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	61/275 (22%)
		POLBc_zeta	1550..2000	CDD:99917	150/470 (32%)
		zf-C4pol	2041..2107	CDD:464119	12/66 (18%)
pold-1	NP_506017.1	PTZ00166	65..1072	CDD:240301	264/1007 (26%)