Protein Alignment PolZ1 and rev-3

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: NP_001299851.1
• Gene: rev-3 / 175809
• WormBaseID: WBGene00021344
• Length: 1303
• Species: Caenorhabditis elegans
• Alignment Length: 2143
• Identity: 471/2143 - (21%)
• Similarity: 727/2143 - (33%)
• Gaps: 917/2143 - (42%)

  Fly    12 YSVRLVIADFYMEKPQFGMDPCYSELRGKEIKRVPVIRVFGGNSRGQKTCMHVHGVFPYLYIPYD 76
            :.:|..|.:...|.|. .||..|:..|.|    :||..::|.....||.|:|:|||.|||.:...
 Worm     3 FCIRNFICEHSQEIPG-PMDTVYNFRRNK----IPVFHIYGVTDTYQKACLHIHGVLPYLVLRVG 62

  Fly    77 KKDFESLERGILQMAMHLDKAI--NISLGQGSSN---AQHVFKIQLVKGIPFYGYHRVEHQFLKI 136
            .|...|:   :..|...::|.|  .|....|.:|   ..:|:|::.......|||...|..|:::
 Worm    63 NKVTPSV---LAAMRAKVNKGIEKEIETSTGKTNKFSVDYVYKMESFSSRSLYGYQDEEEDFVRV 124

  Fly   137 YMFNPRFVRRAANLLQSGAILSKNFSPHESHVPYILQFMIDYNLYGMSYVHVPLEVLKFRR-NHD 200
            |..:|.::::|.:.|....|....|.|:|:|:|:.|||.||.:::||..::  |:.:|||. :.|
 Worm   125 YFSSPWYLKKATHSLGKEVIDKPLFQPYEAHLPFHLQFFIDNSIFGMDNIY--LKKVKFRMDSRD 187

  Fly   201 DDV------IPYANVKQAQLLDITTAKKVACSALEVDVSSNFILNRFQLVAKSKSNH-TNPGIEA 258
            :|.      :...:::..:||.....||..|. :|.|.....|||   :..::.:.| :|||:|.
 Worm   188 EDATLIYKDLSVGDIRNNELLLSPYEKKTTCH-VECDALVTDILN---MEMQADNVHSSNPGLEY 248

  Fly   259 IWNDEKLRRQKLVEKHTDAGDEEKAEAVPVLELPPTQERHQIEIAESDIFYRTALESKLMTLEQS 323
            :|.:||                |:.:|:.: ||             .|:|
 Worm   249 LWREEK----------------ERCDALGI-EL-------------KDVF--------------- 268

  Fly   324 TLSEQTLSDQTILPQATMQTTMPGTKAQKRRFNLQKLLANAVYPEECSQDQQQLLVNASFIQNHV 388
                                                   |:..|.:
 Worm   269 ---------------------------------------NSYEPRK------------------- 275

  Fly   389 TCGYSSSVSLSTSKDESDDLDETVVDEELILSLTQPHGAIPHDATLREEDLELLDALQLLEEQNE 453
                                                                             
 Worm   276 ----------------------------------------------------------------- 275

  Fly   454 SESHVDLDSSLAPLSQHKKFELTPELLDKETAATAALFDEDVDSDEDADQETRHDFSTVLDDVDE 518
                                                                    ||:.
 Worm   276 --------------------------------------------------------STIC----- 279

  Fly   519 LLLKLTQSQPAESKELKASSKLPQIDGADDRLQRTPIKSISSKSKSSPSKTPTTPIGQKSLPKSP 583
                     |.|...|:.:.|:
 Worm   280 ---------PQERDMLRTARKM------------------------------------------- 292

  Fly   584 RTPKTSAAKKYAPLALTIGSSSSKKSNDEFAGRPSNPRLSLQLDQGTGTGTLRPEISLRKKLAMS 648
                   |||:                                               |::..||
 Worm   293 -------AKKF-----------------------------------------------RQERCMS 303

  Fly   649 EMRRKSFEDSFVLLKNDCTPVRSTRRSTSNLDKTHIICSLTPRDRNPGLSDMFETEDGKQLPPKK 713
            |    ..:|..|      |.:..::::||::                |.||
 Worm   304 E----QLDDLMV------TRIAESQQTTSSV----------------GASD-------------- 328

  Fly   714 VVRKTRWSTRNQDIESLPKAGCEIERPHRSEGSALDELKPRRSARHKVNSANPDECSSEIQTTGP 778
               .|.|                 |:|..      |.::..|..|.|    .|:|..:|.|
 Worm   329 ---TTIW-----------------EQPGE------DPMEEDRIGREK----TPEELDAERQ---- 359

  Fly   779 RVTTTSLDRPQKKARLSQSPKENTKTSMNGTVALEKATKDSSSNSESPHQQENSVSEQIEYLES- 842
                                ||..:         |:|.:|..::   |..||   :|...:.:|
 Worm   360 --------------------KEEDR---------EEAAEDDDND---PKNQE---AEMTMFADSQ 389

  Fly   843 KPKKSDETARSCDEKLQRELIPQEPAGISPGDSANSTEEITFSPCHDEAIESDTESDYIVTKLRK 907
            ||.:.||....                                   ||.:|.|.|
 Worm   390 KPVERDEAMDV-----------------------------------DEEVEDDEE---------- 409

  Fly   908 TPNLKRLRWSIRSELLNKQFTPSSGIRPPETETTPQLSPKSNESNTPELMRSFYEHSLIVNSPSV 972
                                                    .|:..|.|::
 Worm   410 ----------------------------------------LNDKGTGEVI--------------- 419

  Fly   973 FSDFLDSPEIHMDSPRSAPPSPDSNSFVIAPLELPPSYDEVVSGSRKMDIPEYEFQKPYYSNPSD 1037
                    ||..|.        |.:..::..:....:||:     ..:.:.|:.|......|...
 Worm   420 --------EISSDG--------DDDQDIVQWITTKSAYDQ-----NFISMNEFLFDAKKIENQRQ 463

  Fly  1038 VSKVTEVGFLVLHIPGNKLNDCDPFQSILGNDRGLASWRRRQLIAIGGLAMLQRHRGEQKVREYF 1102
            .|:              ::..|    |::.::
 Worm   464 FSR--------------EMTAC----SVMTDE--------------------------------- 477

  Fly  1103 STQQRIAIEPAQLAPTWQEAKIWLKAKELLRQREEPKKSSDDIDSPIKIKRQKITMMLQAEEGDG 1167
                                                                  |::..||...
 Worm   478 ------------------------------------------------------TVVAAAEHSQ- 487

  Fly  1168 GSGDEDAGEELDCSLSLTPLSQAKDKCKATPTSSKARETGKSRLKRGTRLSFIGSQDEEPPSSQS 1232
                              |:.|                   :||...|.:.       ||.:|:.
 Worm   488 ------------------PVEQ-------------------TRLLSQTSIG-------EPSTSEK 508

  Fly  1233 SEQSVSSSAAQAELDRSSFLRQLEGSSQDRQHDLSFGLSHATLDNTFGFKVNLENLQQAKADIDC 1297
            |.:|                                                           |.
 Worm   509 SVES-----------------------------------------------------------DI 514

  Fly  1298 NHLTIITLEVFVSTRGDLQPDPMHDEIRCLFYAIEHSLPDEKLPSKACGYIMVNTVQDLLSEGPF 1362
            ..|.:.:||:.|.|:..: ||....||..:..||.:.:       ..|....::.:...|..||.
 Worm   515 VGLCVASLELLVDTKMPM-PDAASSEIVSVSLAIYNDV-------CRCSSPKLHVLLTTLPVGPA 571

  Fly  1363 HGIDRDIEVQVVTSEAEAFEALLALCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRV 1427
            :...|.:.::   :|.|..|.:.....::|.|:..|||....|||:...|.|.|...|:  :.|.
 Worm   572 YSDRRVVHME---TELEMLEEVAKWIVQYDVDVMIGYETIRLSWGFFFRRIKLLGSRIS--MDRA 631

  Fly  1428 PTQKVRDFVDEDREQFTDLDVEMKLCGRILLDVWRLMRSEIALTSYTFENVMYHILHKRCPWHTA 1492
            ......|.::.|.::.|....:    ||:|:.||:::||::||.:|...:.:.::|.|:.|....
 Worm   632 LIDAYEDHIEVDDQEITVAPPK----GRLLVSVWKVVRSDLALRNYDLGSAVANVLRKKIPMLDN 692

  Fly  1493 KSLTEWFGSPCTRWIVMEYYLERVRG-------------------TLTLLDQLDLLGRTSEMAKL 1538
            .:|                 :.|::|                   .::||.:::...:.:|||::
 Worm   693 AAL-----------------MRRIKGERSAIRNDVHLHLLKLSSLNISLLTEMNWFLKNAEMARV 740

  Fly  1539 IGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQARAHMRAPEYLALIMEPQSRFYADPLI 1603
            .||||:||.:||||.|||||:||:|...|.|..|.:...|..|.:||.|.||:||||:.|.||:|
 Worm   741 YGIQFHEVWTRGSQLRVESMLLRLAHRMNFVAPSITHLQRNMMGSPEQLQLILEPQSKVYFDPVI 805

  Fly  1604 VLDFQSLYPSMIIAYNYCFSTCLGRVEHL-------GGSSPFEFGASQLRVSRQMLQKLLEHDLV 1661
            |||||||||||:||||||:||.||::.:|       ........||.:...|:..:.||:.:..|
 Worm   806 VLDFQSLYPSMVIAYNYCYSTILGKIGNLVQMNDESRNREEIVLGAIKYHPSKDDIVKLVAYKEV 870

  Fly  1662 TVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMANVTY 1726
            ..||...:|||:..|||::|.:|.|||..|.|||.:||..|:.. |:|||.:|||.|||:|||:|
 Worm   871 CASPLASMFVKKSKREGVMPLLLREILAARIMVKSAMKRTKNKK-LKRILDARQLALKLVANVSY 934

  Fly  1727 GYTAANFSGRMPSVEVGDSVVSKGRETLERAIKLVENNEEWKVRVVYGDTDSMFVLVPGRNRAEA 1791
            ||||||:|||||..|:.|:::.||||||||:|::|:..:.....|:|||||||||||.|.:..||
 Worm   935 GYTAANWSGRMPCAELADAILGKGRETLERSIEMVQRGDYGGAEVIYGDTDSMFVLVRGASVEEA 999

  Fly  1792 FRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGYMYETADQEQPVYEAKGIETVRRDG 1856
            |.||..|...||..||.||.|||||||:.|:|:|||||.|:|||..:.|..: :||||||||||.
 Worm  1000 FEIGRRIVDDVTNSNPDPVVLKLEKVYKGCVLETKKRYAGWMYEHENDEGSL-DAKGIETVRRDT 1063

  Fly  1857 CPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKLLS-GRANLQDLIFAKEFRGLNGYKPTACVP 1920
            ||.||::|||.|.::|.    ...|.::....|.:|: .:.|....:|.||:||  .|...|.||
 Worm  1064 CPIVAEVLEKSLGLIFS----QNWKTFITYLNTVVLNLPQENFSKFVFCKEYRG--DYSARAMVP 1122

  Fly  1921 ALELTRKWMQKDPRHVPRRGERVPFIIVNGPPGMQLIRLVRSPHDILANEGHKINAIYYITKAII 1985
            ..::....::|.|.|:..||||||::|::|..|..:...|||......|..:|||..||:...|:
 Worm  1123 QKKIAEARIRKCPSHITLRGERVPYVIIDGVTGSTVYSCVRSIDQFARNPEYKINTFYYLNAHIL 1187

  Fly  1986 PPLNRCLLLIGANVHDWFASLPRKLLMTPAVGTANELAGARGAKSTISQYFSTTSC-VIDCGRQT 2049
            ..|.|...||           |.|:...|                     |:...| |.||.|..
 Worm  1188 AALRRVTDLI-----------PMKIDFLP---------------------FAAEQCFVSDCSRIG 1220

  Fly  2050 KAGICPDCLKNATTCVVVLSDKTARLERGYQLTRQI------CQACCGRLGS---LQCDSLDC 2103
            |...|.:|.:|.....:.|    .:|.|..:...||      ||:...|||.   :.|.:..|
 Worm  1221 KTPWCIECEQNPEELALAL----VQLGRESRARSQIIQYCTSCQSSSQRLGEDQVVDCANFTC 1279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301	54/180 (30%)
		DNA_polB_zeta_exo	1297..1518	CDD:99821	50/220 (23%)
		POLBc_zeta	1550..2000	CDD:99917	216/457 (47%)
		zf-C4pol	2041..2107	CDD:464119	21/73 (29%)
rev-3	NP_001299851.1	PTZ00166	14..>237	CDD:240301	68/236 (29%)
		DnaQ_like_exo	517..725	CDD:447876	51/241 (21%)
		POLBc_zeta	752..1201	CDD:99917	217/467 (46%)