Protein Alignment PolZ1 and pole-1

DIOPT Version :10

• Sequence 1: NP_524881.2
• Gene: PolZ1 / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Sequence 2: NP_493616.1
• Gene: pole-1 / 173368
• WormBaseID: WBGene00009368
• Length: 2144
• Species: Caenorhabditis elegans
• Alignment Length: 1401
• Identity: 249/1401 - (17%)
• Similarity: 434/1401 - (30%)
• Gaps: 518/1401 - (36%)

  Fly  1091 RHRGEQKVREYFSTQQRIAIEPAQLAPTWQEAKIWLKAKELLRQREEPKKSSDDIDSPIKIK--- 1152
            |:.|.|:.:.:.     |.|:|::|..  ::.|:.:...:..        ...|:|...||.
 Worm    39 RYTGLQEKKGFL-----INIQPSELVD--EQTKVIISVVDYF--------FISDMDERFKISYPF 88

  Fly  1153 ------------RQKITMMLQAEEGDGGSGDEDAGEELDCSLSLTPLSQAKDKCKATPTSSKARE 1205
                        ..:::..|..:.|...:.:....|:||....|:.|.:...|...|.|
 Worm    89 RPYFYIATLDGFEFQVSSYLSKKYGAQTAVEHMDREDLDLKDHLSGLKKTYIKLSFTST------ 147

  Fly  1206 TGKSRLKRGTRLSFIGSQDEEPPSSQSSEQSVSSSAAQAELDRSSFLRQLEGSSQD--------- 1261
                       :..|..:.|..|..:.:...:...:|.|:.    ..|.|.|...|
 Worm   148 -----------VELIKIRKELMPLVRKNTDRIKKESAYADY----LARNLSGKGGDSKDQQLNGD 197

  Fly  1262 --------RQHDLSFGLSHATLDNTF-GFKVNLENLQQ------AKADIDCNHL--TIITLEVFV 1309
                    |::|:.|.:..:..:..| |...:::.:..      .:.|:...|.  .::..:: .
 Worm   198 ILNQIVDIREYDVPFHMRVSIDEKIFVGLWYDVKGIGPNRVPTIKRKDLPLFHAKPKVLAFDI-E 261

  Fly  1310 STRGDLQ-PDPMHDEIRCLFYAIEHSLPDEKLPSKACGYIMVNTVQDLLSEGPFHGIDRDIEVQV 1373
            :|:..|: ||...|||..:.|.::           ..|::::|  ::::|        .||....
 Worm   262 TTKLPLKFPDRESDEIMMISYMVD-----------GRGFLIIN--REIVS--------ADINAFE 305

  Fly  1374 VTSEAEAFEALLALCERWDA---------------DIYAGYEIEMSSWGYVIDRAKHLCFNIAPL 1423
            .|.:||.........|:.:|               :|...|..:...|.:|..|||...||:...
 Worm   306 YTPKAEYIGEFTVWNEKDEAALIRKFFDHFLQVRPNIVVTYNGDFFDWPFVEARAKIRGFNMERE 370

  Fly  1424 L-----------SR------------------VPTQKVRDFVDEDREQFTDLDVEMKLCGRILLD 1459
            :           ||                  |.:|.:: .|.:.:.::..::||.:|..::..:
 Worm   371 IGFSKDSADEYKSRNCIHMDAFRWVKRDSYLPVGSQNLK-AVTKAKLRYDPVEVEPELMCKMARE 434

  Fly  1460 VWRLMR----SEIALTSYTFENVMYHILHKRC---PWHTAKSLTEWFGSPCTRWIVMEYYLERV- 1516
            ..:.:.    |:...|.|.:...::..:...|   |......|.:..|:.|...:::|.:...:
 Worm   435 QPQQLANYSVSDAVSTYYLYMKYVHQFIFALCTIIPLGADDVLRKGSGTLCEALLMVEAFHNNIV 499

  Fly  1517 ---RGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSRGSQFRVE-SMMLRIAKPKNLVPLSPSVQA 1577
               :.|.....:....|...|....:| ...|.|..| .||.: ....|::.|. |..|...:|.
 Worm   500 FPNKYTGPEETRFSKDGHRVESETYVG-GHVEALEAG-VFRADIPAKFRLSVPA-LEQLKSEIQE 561

  Fly  1578 RAHMR-APEYLALI----------MEPQSRF---------YADPLIV-LDFQSLYPSMII----- 1616
            ..... |.|:...:          .|.|..|         ..:|.|. ||..::||::|:
 Worm   562 TLRKELAREFEVTLDQVVDFDEQCAEVQDAFDGMINVPTRLENPRIYHLDVGAMYPNIILTNRLQ 626

  Fly  1617 -------------AYNYCFSTCLGRV--EHLGGSSPFEFGASQLRVSRQMLQKLLEHDLVTVSPC 1666
                         :||...:.|...:  |..|..:|...|..|     |::|: ||.:.....|.
 Worm   627 PCAMVTEEICMGCSYNKPDAECKRTMAWEWRGELTPATRGEYQ-----QIMQQ-LEAESFGKPPK 685

  Fly  1667 GVVFVKREVREGI-----------------LPRM------------------LTEILDTRQMVKQ 1696
            ....::|..||.|                 |.|:                  :....|.|...|.
 Worm   686 HFHMLERSEREAIEMKRIKDYSRRVYGKTHLTRLEMRETTICQRENHFYVETVKAFRDRRYEYKD 750

  Fly  1697 SMKLHK---------------DSSALQRILH-SRQLGLKLMANVTYGYTAANFSGRMPSVEVGDS 1745
            .:|..|               .:|.|:.:|: |.||..|.:.|..|||.....| |..|:|:...
 Worm   751 MLKKAKGRFDQAQATNDLATMTTSKLEMVLYESLQLAHKCILNSFYGYVMRKGS-RWFSMEMAGI 814

  Fly  1746 VVSKGRETLERAIKLVENNEEWKVRVVYG-----DTDSMFVLVPGR-NRAEAFRIGEEIAKAVTE 1804
            |...|...:..|.||||.         .|     |||.::.|:|.. .....|::......:||.
 Worm   815 VCHTGANIIREARKLVEQ---------IGTPLELDTDGIWCLIPASFPENVTFKLKNHKRSSVTV 870

  Fly  1805 MNP-------------------------------QPVKLKLEKVYQPCML---------QTKKRY 1829
            ..|                               ..:..:::..|| ||:         :.||||
 Worm   871 SYPGAMLNALVYEGFTNHQYHTLEKDGSYSKSSENSIYFEVDGPYQ-CMILPASKEEGKKLKKRY 934

  Fly  1830 VGYMYETADQEQPVYEAKGIETVRR---------DGC---------------PAVAKML------ 1864
            ..:     :.:..:.|.||.|..||         .||               .|||...
 Worm   935 AVF-----NLDGSLAEMKGFELKRRGELNIIKHFQGCVFKTFLNGKTLEETYKAVAADADHWLDI 994

  Fly  1865 ----------EKVLRILFETQDVS-KIKAYVCRQFTKLLSGRANLQDLIFAKEFRGLNGYKPT-- 1916
                      |::..::.|.:.:| |::.|..::.|.:.:.:.       ..||.|.:..|..
 Worm   995 LHSHGADLTDEELFDLISENRSMSRKLEDYGAQKSTSISTAKR-------LAEFLGDDMVKDAGL 1052

  Fly  1917 ACV----------PALE-----------------LTRKWMQK-------DPR-------HVPRRG 1940
            ||:          |..|                 ..|||.::       |.|       ::.|.|
 Worm  1053 ACMFIISKHPIGAPVTERAIPVAIFKSDAKVRSHYIRKWTKQVDFNEDTDIRDMLDWDYYLERFG 1117

  Fly  1941 ERVPFIIVNGPPGMQLIR--LVRSPH-DILAN------EGHKINAIYYITKAIIPPLNRCLLLIG 1996
            ..:..||.. |..:|.|.  :.|.|| |.|.|      :.|:           .|.:|:.
 Worm  1118 SCIQKIITI-PAALQGISNPVPRVPHPDWLQNKIRNKFDAHR-----------QPRINQI----- 1165

  Fly  1997 ANVHDWFASLPR---------KLLMTPAVGTANELA---------------GARGAKSTISQYFS 2037
                  ||:..:         |...||....|:|.|               ||:..|:|
 Worm  1166 ------FAACQKPSTSQMDNGKRRRTPDDDVASEDAMDSQDDIIIDDDKENGAKRQKNT------ 1218

  Fly  2038 TTSCVIDCGRQTKAGICPDCLKNATTCVVVLSDKTARLERGYQLTRQICQACCGRLGSL------ 2096
                                 |...|..|||..||. :|.|:.          ..:|.|
 Worm  1219 ---------------------KKVHTTEVVLEKKTL-VEHGFD----------EWMGFLKKKWRV 1251

  Fly  2097 -------QCDSLDCPVLYVLEGKRRELQQIEHWNKL 2125
                   |..|.|..|:..:....||.:..:.|:.|
 Worm  1252 QRKERKTQLSSKDSDVVEAIVRGAREAEHDKEWHIL 1287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolZ1	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	45/278 (16%)
		POLBc_zeta	1550..2000	CDD:99917	130/681 (19%)
		zf-C4pol	2041..2107	CDD:464119	15/78 (19%)
pole-1	NP_493616.1	DNA_polB_epsilon_exo	253..455	CDD:99822	38/224 (17%)
		POLBc_epsilon	516..1132	CDD:99918	124/648 (19%)
		DUF1744	1468..1869	CDD:462493