DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NCK1 and CG8907

DIOPT Version :9

Sequence 1:	NP_001278928.1	Gene:	NCK1 / 4690	HGNCID:	7664	Length:	377	Species:	Homo sapiens
Sequence 2:	NP_001247146.1	Gene:	CG8907 / 42050	FlyBaseID:	FBgn0038466	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	207	Identity:	39/207 - (18%)
Similarity:	77/207 - (37%)	Gaps:	71/207 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    11 FDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKN-----------SARK 64
            |:..|..::||.:.|.|.|.::|||::||:.|||....|:||...:...|           |...
  Fly   444 FNKSATNDKELKVTKGEYLEIIDDSRNWWKARNSYGNIGYVPHTVLTPYNFEPGVNGRDTESLAS 508

Human    65 ASIVKN----------LKDTLGI-----------GKVKRK----PSVP---------DSASPADD 95
            .::.:|          .::|:.:           ||..::    |:||         ||.:|...
  Fly   509 MALTENGGEEAIPPPLYRNTMAMYTAPVEQPAANGKAMQRTFSMPNVPVPPPMPPPSDSQTPTPS 573

Human    96 SFV-------------------DPGERLYDLNMPAYVKFNYM---AEREDELSLIKGTKVIVMEK 138
            ..:                   :..::||.:....:.:...:   .||..:|.::|..::.:.:.
  Fly   574 GTLKRNMAAAGALAAMRARNDCEADDQLYYMQGDVHDELRLLQQQRERRKDLEILKTPEIFITQN 638

Human   139 CS----DGWWRG 146
            ..    :.|.||
  Fly   639 SKPSEVEEWLRG 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCK1	NP_001278928.1	SH3_Nck1_1	3..61	CDD:212833	19/60 (32%)
		SH3_Nck1_2	108..162	CDD:212834	7/46 (15%)
		SH3_Nck1_3	193..249	CDD:212837
		SH2_Nck1	280..376	CDD:198271
CG8907	NP_001247146.1	PTB_EPS8	43..175	CDD:269921
		SH3_Eps8	439..492	CDD:212698	18/47 (38%)
		SAM_superfamily	635..699	CDD:301707	3/16 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910