DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NCK1 and EndoB

DIOPT Version :9

Sequence 1:	NP_001278928.1	Gene:	NCK1 / 4690	HGNCID:	7664	Length:	377	Species:	Homo sapiens
Sequence 2:	NP_611410.1	Gene:	EndoB / 37218	FlyBaseID:	FBgn0034433	Length:	390	Species:	Drosophila melanogaster

Alignment Length:	253	Identity:	53/253 - (20%)
Similarity:	96/253 - (37%)	Gaps:	85/253 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    57 ERKNSARKASIVKNLKDTLGI--GKVKRKPSV-----PDSASPADDSFVDPGERLYDLNMPAYVK 114
            |.|...::..|::..:..|..  .:||:..|:     .|..||  ::.::..||  ||.: |..:
  Fly   156 EMKTIGKERGILETKRLDLDACKNRVKKARSMLGQQSKDGISP--EAVLEQAER--DLRV-AQAE 215

Human   115 FNYMAEREDELS--LIKG-----------------TKVIVMEKCSDGWWR-----GSYNGQVGWF 155
            |    :|:.|::  |:.|                 |:|...::|.|...:     .:..|...:.
  Fly   216 F----DRQAEITKLLLDGISTSQASHLRHLHAFIQTQVRYYKQCGDVMEQLQRELANLGGPTPYI 276

Human   156 PSNYVTEEGDS------------PLGDHVGSLSEKLAAVVNNLNTGQVLHV-------VQALYPF 201
            |.: |.|...|            |..:|    |..:||..:..|  |.:||       .:.|..:
  Fly   277 PLD-VNEASASKSNISSGAAARGPGNNH----SANMAATGHKPN--QPMHVSTDQMQRARVLCSY 334

Human   202 SSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKIN--------GMV-GLVPKNYVTVM 250
            .:.:..|||....:|:.|.|          |..:|        |:: ||||:.:|.::
  Fly   335 DAKDHTELNLSANEVIFVTE----------CSPVNEDYMYGKQGLLKGLVPRAFVEML 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCK1	NP_001278928.1	SH3_Nck1_1	3..61	CDD:212833	2/3 (67%)
		SH3_Nck1_2	108..162	CDD:212834	13/77 (17%)
		SH3_Nck1_3	193..249	CDD:212837	17/71 (24%)
		SH2_Nck1	280..376	CDD:198271
EndoB	NP_611410.1	BAR_Endophilin_B	26..266	CDD:153278	24/118 (20%)
EndoB	NP_611410.1	SH3_Endophilin_B	327..378	CDD:212736	14/60 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910