DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NCK1 and dock

DIOPT Version :9

Sequence 1:	NP_001278928.1	Gene:	NCK1 / 4690	HGNCID:	7664	Length:	377	Species:	Homo sapiens
Sequence 2:	NP_001259845.1	Gene:	dock / 33262	FlyBaseID:	FBgn0010583	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	411	Identity:	184/411 - (44%)
Similarity:	257/411 - (62%)	Gaps:	64/411 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     7 VVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIVKNL 71
            ||||:||.||..||||::||||..||||||.||||:||.|::|:||||||:::..:...||.|.:
  Fly   155 VVAKYDYAAQGAQELDLRKNERYLLLDDSKHWWRVQNSRNQSGYVPSNYVKKEKPSLFDSIKKKV 219

Human    72 KDTLGIGKVKRKPSVPDS---ASPADDSFV--DPGERLYDLNMPAYVKFNYMAEREDELSLIKGT 131
            |.  |.|. |..|:...|   .||.....:  ||.|.:    ..|.||:||.|::.|||||.|||
  Fly   220 KK--GSGS-KTLPNCSPSRQVESPTMSRRLPPDPAEAI----GTAVVKYNYQAQQPDELSLTKGT 277

Human   132 KVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQ 196
            :::::||.:||||||.....||||||||.||:.|:....|..:::|            .||.:|.
  Fly   278 RILILEKSNDGWWRGQSGNSVGWFPSNYTTEDCDNDGEIHTYAMAE------------NVLDIVV 330

Human   197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYV--------TVMQNN 253
            |||.|:|:||:||:|||||.::::::|.:||:|:|.|...|.|||||:||:        |..:|.
  Fly   331 ALYSFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARNNQGQVGLVPRNYLQELNDYLATPYRNA 395

Human   254 PLTSG-----------------------LEPSPPQCD-----YIRPSLTGKFAGNPWYYGKVTRH 290
            ..::|                       .|.:.|...     ..||:|.||    .||||.:||.
  Fly   396 SASAGNGNGGGSNGGAGGGGGNDSMERRNEGNKPAAQSSGQPIERPNLAGK----SWYYGAITRS 456

Human   291 QAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEH 355
            |.:..||..||:|||||||||::..|:||||||.|:||||:|.:::.:||||||||.::::||:|
  Fly   457 QCDTVLNGHGHDGDFLIRDSETNMGDYSVSLKAPGRNKHFRVHVEQNMYCIGQRKFHSLDQLVDH 521

Human   356 YKKAPIFTSEQGEKLYLVKHL 376
            |::|||:|::||||||||:.|
  Fly   522 YQRAPIYTNKQGEKLYLVRSL 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCK1	NP_001278928.1	SH3_Nck1_1	3..61	CDD:212833	36/53 (68%)
		SH3_Nck1_2	108..162	CDD:212834	30/53 (57%)
		SH3_Nck1_3	193..249	CDD:212837	29/63 (46%)
		SH2_Nck1	280..376	CDD:198271	57/95 (60%)
dock	NP_001259845.1	SH3_Nck_1	154..204	CDD:212699	34/48 (71%)
		SH3_Nck_2	256..308	CDD:212700	30/51 (59%)
		SH3_Nck_3	328..383	CDD:212701	29/54 (54%)
		SH2_Nck_family	446..538	CDD:198196	55/95 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148271
Domainoid	1	1.000	110	1.000	Domainoid score	I6300
eggNOG	1	0.900	-	-		E1_KOG4226
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38148
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2370
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46567
OrthoDB	1	1.010	-	-		D1097449at2759
OrthoFinder	1	1.000	-	-		FOG0002240
OrthoInspector	1	1.000	-	-		otm40407
orthoMCL	1	0.900	-	-		OOG6_106243
Panther	1	1.100	-	-	LDO	PTHR19969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4150
SonicParanoid	1	1.000	-	-		X1672
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800