DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NCK1 and Socs16D

DIOPT Version :9

Sequence 1:	NP_001278928.1	Gene:	NCK1 / 4690	HGNCID:	7664	Length:	377	Species:	Homo sapiens
Sequence 2:	NP_001259662.1	Gene:	Socs16D / 32760	FlyBaseID:	FBgn0030869	Length:	1021	Species:	Drosophila melanogaster

Alignment Length:	401	Identity:	78/401 - (19%)
Similarity:	138/401 - (34%)	Gaps:	101/401 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    26 NERLWLL--DDSKSWWRVRNSMNKT---GFVPSNYVERKNSARKAS-----------------IV 68
            ||.:|.:  :.:.:..|.|:|:..|   |..|.    ..|.|..||                 :.
  Fly   587 NETIWSVSTNTTTTTARTRSSVGTTRGGGGPPG----AGNGAGGASSDGGVGGGSAGGGGGKYLS 647

Human    69 KNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSL---IKG 130
            |..|..|...|:....:..::..|:......|....::.:.|...|....:|::.:.:|   .:.
  Fly   648 KQNKHNLDNDKLNNNNNNNNNHQPSQQQLEKPPTEHHNQHQPPNNKHVLHSEKKSQFTLNLKQRF 712

Human   131 TKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSE--------KLAAVVNNLN 187
            ..:....:.:....|||.|.|.|.|.|........:||...:..::.        :||:.:|.
  Fly   713 CSIFRFRRSNHSRCRGSGNNQTGTFASANANAAATAPLIPPIAVITSAPGAAGQTQLASELNG-- 775

Human   188 TGQVLHVVQALYPFSSSNDEELNFEKGDVMDV-------------IEKPENDPEWWKCRKINGMV 239
               .|...:|..|   :.|....|:...:..:             ||..:::||..|...|....
  Fly   776 ---TLITAEADEP---NADLRKKFQSRALPPLPKKALPFTAAAYAIEAVKSEPEEVKTNAIQEPR 834

Human   240 GLVPKNYVTVMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGD 304
            .|            ..||.:|               |.....||:|.::...||..|:.. .:|.
  Fly   835 AL------------QFTSSIE---------------KVKDYGWYWGPLSSEAAEKVLSSE-PDGS 871

Human   305 FLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQ-RKFST------MEELVEHYKKAPIF 362
            |::|||......||:|.|.....:|.:::..:..:..|. .||.:      :|:.|||
  Fly   872 FIVRDSSDDHYIFSLSFKLNNCVRHVRIEQDQGTFSFGSYAKFKSQTITEFIEKAVEH------- 929

Human   363 TSEQGEKLYLV 373
             |..|..|:.:
  Fly   930 -SRSGRYLFFL 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCK1	NP_001278928.1	SH3_Nck1_1	3..61	CDD:212833	9/39 (23%)
		SH3_Nck1_2	108..162	CDD:212834	12/56 (21%)
		SH3_Nck1_3	193..249	CDD:212837	11/68 (16%)
		SH2_Nck1	280..376	CDD:198271	26/101 (26%)
Socs16D	NP_001259662.1	SH2_SOCS7	839..937	CDD:198251	29/121 (24%)
Socs16D	NP_001259662.1	SOCS_SOCS7	960..1009	CDD:239710
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910