DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gug and atn1

DIOPT Version :9

Sequence 1:	NP_001261581.1	Gene:	Gug / 46156	FlyBaseID:	FBgn0010825	Length:	2007	Species:	Drosophila melanogaster
Sequence 2:	XP_002941264.2	Gene:	atn1 / 100486351	XenbaseID:	XB-GENE-6458762	Length:	1129	Species:	Xenopus tropicalis

Alignment Length:	1329	Identity:	319/1329 - (24%)
Similarity:	419/1329 - (31%)	Gaps:	518/1329 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   930 KSSPYGPPPESPIDASARSTPGQDSQGSNSNSQPPSMPPQPQ----------------------- 971
            |....||..|.  .|..|::||..|..|:.:......|...:
Frog    33 KKESVGPREER--RARGRASPGAISTSSSDSKSEKGRPSGKKGRMEDSVPKNSKRERVKDSSESE 95

  Fly   972 ------QFQSPHPSPHMPSPAGGGLPPGMHPQNLIHGPPPGAAGGSGPQPPPPPTSLHQPTPTSA 1030
                  |.::...||.:|.|     ||   ....:.|......|||.|:      .:.|...:::
Frog    96 GEAGKTQKKAKMESPEVPRP-----PP---DDESLDGQSGNEDGGSDPR------DIDQDNRSTS 146

  Fly  1031 GPPSLQHGLHPGHQHSQLSVASSIP-PSSIGIPPTLSTMAPSHMHPHLHPHAHLQGLHRPHDLPP 1094
              ||    ||.|...|.   |||:| |.|.   |.....:|        |......:..|..|||
Frog   147 --PS----LHSGDSESD---ASSVPSPKSF---PLYRGSSP--------PRPSSSPISEPTVLPP 191

  Fly  1095 ---------SMHPHAPMPLSLQGHPQHGHGLPPSHTSQQQQQQQQQQQPGGPAGTVRT--PSPAQ 1148
                     .:.|.||.|.    .|.|...|.||:                 .|.|:.  |.|||
Frog   192 PSQAPQTATQIEPQAPRPY----QPTHLPQLYPSN-----------------GGLVKAGPPQPAQ 235

  Fly  1149 QPPRSMHDPQSSREPPTSQPSTTMAGSSGPGGPPPQQSPHAHRTSPLPGLAGSGPPPPGLIGHPM 1213
            ..|           |||    |.:||.   |.|.|..||.|..::| ...:.|
Frog   236 VKP-----------PPT----TPIAGL---GSPRPLGSPTAPASAP-TNCSSS------------ 269

  Fly  1214 AIHPHLAH-LPPGHPAHAALAHPGHHLLSHSIAGLGPGGGPIALLAGPGGLGGIPESALSRRTP- 1276
            |.:||::| |||........|.||   |...:|  ...|.|:.           |.||..|..|
Frog   270 ASYPHVSHNLPPPPALRPLNASPG---LQSQVA--EKVGQPLP-----------PTSASLRYPPY 318

  Fly  1277 ----PSHLPHSHASSAPLTAHSVASMTSTSMSLTTSTVPSSAFSRASPSVQISSSGGGPSGPGSV 1337
                ||:.||.:.:..........              |.|::.::  .:.....|||||.|..
Frog   319 PGQYPSNYPHPYPTQGKYNQPQPG--------------PHSSWGQS--GLNYGRGGGGPSYPQP- 366

  Fly  1338 GPGGMPNSSAAAAAAAAAHRAASPASSVSSLSRQSPLHPVPQSPLSHHPSSSALSAAAAAVAERD 1402
                 |..:..||..........|.....|...||||:..|..|   ||::..:.:.|:.::...
Frog   367 -----PPQNGQAAGGGQNIAGGFPPPHHGSARAQSPLNNHPPHP---HPTTGGIQSPASQISVLH 423

  Fly  1403 RH---ALMRQQSPHMTPPPVSNASLMASPLSKMYAPQ--PGQRGLGTSPPPHLRPGASPPVIRHP 1462
            .|   :..|.|||:             .||:..:.|.  | .||...:|..:|.||::|.....|
Frog   424 SHGGASGTRGQSPN-------------HPLNNAHHPHILP-NRGRSPTPQSNLTPGSTPQSGHQP 474

  Fly  1463 QMPLPLPLIAP--------------GGG--------------IPQIGVHPGQSPYPHPL------ 1493
            ...||..:|:|              ||.              :||.....|...||.|.
Frog   475 AHILPGGIISPNPPPQNNTQLTSSTGGSARGQSPAPTNTPHLLPQSNSSSGSMAYPAPAEPSNPP 539

  Fly  1494 -LHPSVFYSPHHHPFNSPYGYAPYGPGFPAYMKPPPQPGQLDPAAVMAAHHAGLQGPPPQQMRQD 1557
             .||  .|.||..|  |...|.|....:|.|      |.|            |.:|.||
Frog   540 STHP--VYQPHSSP--SVCQYPPSSQTYPNY------PFQ------------GYKGAPP------ 576

  Fly  1558 EQNAAAAAAQAAAEKQHQAAAAAAAQQHKAPQQQQPGGMPPNKPPTPKTPQGPGGGMPPGMGGPG 1622
                                 ||...:...|...:||..|.:.||.|               ..|
Frog   577 ---------------------AAPPYKTAPPPPYKPGSFPASTPPPP---------------SQG 605

  Fly  1623 TPTGLPPGAYPGSHMPGYPQGPPHGSPFAPQDGQPHGLKPTSHMDALRAHAHSANSAGMGGGHHP 1687
            .....||...|.      ||..|...|                                    .|
Frog   606 FKEASPPATAPA------PQPVPQPVP------------------------------------QP 628

  Fly  1688 TEPLPIDIEPDPEPEI----PSPTHNIPRGPSPEAKPDDTECHRSQSAIFVRHIDRGDYNSCTRT 1748
            ..|.|:.|:.:|..|:    .||...: ..|||..|..||..|.||||.|.:|:||| ||||.||
Frog   629 PAPAPVQIKQEPPEEVEGEGESPVPPV-SSPSPPPKLVDTPSHASQSARFNKHLDRG-YNSCCRT 691

  Fly  1749 DLIFKPVADSKLARKR-----------EERDRKLAEKERERRQQQQQQ--------------QQQ 1788
            ||.|.|:..|||::||           |:|.|:..|:||||.::.::.              .|.
Frog   692 DLYFVPLEGSKLSKKRSEQIERARRESEQRAREERERERERERELERNTKLDSRSHDCPQLCTQP 756

  Fly  1789 QQQQQAAAAQQAAQQAKMKAELKPPYA----------DTPALRQLSEYARPHVAFSPVEQMV--- 1840
            .....:.|....:..|......:||.|          ||||||.||||||||| .||..:..
Frog   757 PSHHPSLALPSPSSAANRPPHFEPPGAVAAVPPYLGPDTPALRTLSEYARPHV-LSPAGRAQPPG 820

  Fly  1841 -PYHHPM-------------------GPMYRERELEEIKNAQAAAASQSRLDPHWMEYYRRGIHP 1885
             |.|||.                   .|...||||.| :...........|||         :||
Frog   821 HPPHHPFYLPLGDPLLAYNLPAVFASDPARAERELRE-RLKPGYEVKPGELDP---------LHP 875

  Fly  1886 SQFPLYANP----AISQMERERLGIPP--------PHHVG-------------------LDPG-- 1917
            |..||...|    |..|......|:||        |:|.|                   ..||
Frog   876 SSIPLPPPPPHHHAPHQPPPSAAGVPPQMALHPAFPYHHGQHAHAHALERERLALGAAAAGPGGA 940

  Fly  1918 ------------------------EH----------------MIRLTREYHAHSHTHLHLPLHPQ 1942
                                    :|                |:.:|..:|.|||.|.||.||.|
Frog   941 QGATAAAGAGRGELSYAERLAAERQHAERVAALSGDPLARLQMLNVTPHHHQHSHIHSHLHLHQQ 1005

  Fly  1943 PQPPEAGFQLPPNVG-----------QYPR---PNMLIPREPH-SDVLLR--------------- 1977
            .....|...:.|.:.           .||.   ||.|||...| ||||.:
Frog  1006 DAIHAASAAVHPLMDPLASGSHLTRIPYPATTLPNTLIPHALHDSDVLRQQIFASPYRDLPSALS 1070

  Fly  1978 --MSYADQLQ--YLQAAEFQRQSLHDQYF 2002
              :|.|.|||  :.|:||.||.:|..|::
Frog  1071 APLSAAHQLQAMHAQSAELQRLALEQQHW 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gug	NP_001261581.1	ELM2	9..68	CDD:279754
		SANT	125..172	CDD:197842
		SANT_MTA3_like	126..171	CDD:212559
		Sec_Non_Glob	344..>440	CDD:275213
atn1	XP_002941264.2	Atrophin-1	17..1127	CDD:367360	319/1329 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4065
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2540
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003731
OrthoInspector	1	1.000	-	-		otm48519
Panther	1	1.100	-	-	LDO	PTHR13859
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.150