DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phb2 and phb2b

DIOPT Version :9

Sequence 1:	NP_001097372.1	Gene:	Phb2 / 46038	FlyBaseID:	FBgn0010551	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_001002681.2	Gene:	phb2b / 436954	ZFINID:	ZDB-GENE-040718-430	Length:	303	Species:	Danio rerio

Alignment Length:	288	Identity:	210/288 - (72%)
Similarity:	253/288 - (87%)	Gaps:	2/288 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LNDLAGKLGKGGPPGLGIGLKVLAAVGAAAYGVSQSLYTVEGGHRAIIFSRLGGIQSD-IYSEGL 69
            |.||.|::..|. .|.|||||:|...||.||||.::.||||||.|||||:|:||:|.| :.:|||
Zfish    13 LRDLMGRISSGS-RGAGIGLKLLIGAGALAYGVREATYTVEGGQRAIIFNRIGGVQLDTVLTEGL 76

  Fly    70 HVRIPWFQYPIIYDIRSRPRKISSPTGSKDLQMINISLRVLSRPDSLNLPYLHKQLGVDYDEKVL 134
            |.||||||||||||||:|||||||.||||||||:||:|||||||.:.|||.:::|||.||||:||
Zfish    77 HFRIPWFQYPIIYDIRARPRKISSLTGSKDLQMVNIALRVLSRPLASNLPIMYQQLGQDYDERVL 141

  Fly   135 PSICNEVLKSVIAKFNASQLITQRQQVSLLIRKELVERARDFNIILDDVSLTELSFGKEYTAAIE 199
            |||.|||||||:||||||||||||.|||||||:||.|||:|||||||||::|||||.:|||||:|
Zfish   142 PSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELFERAKDFNIILDDVAITELSFSREYTAAVE 206

  Fly   200 AKQVAQQEAQRAVFFVERAKQEKQQKIVQAEGEAEAAKMLGLAVKQNPAYLKLRKLRAAQSIART 264
            ||||||||||||.||||:||||::|||:||||||:||||||.||.:||.|||||::||||:||:|
Zfish   207 AKQVAQQEAQRAQFFVEKAKQEQKQKIIQAEGEAQAAKMLGEAVTKNPGYLKLRRIRAAQNIAKT 271

  Fly   265 IASSQNKVYLSADSLMLNIQDSGFDDMT 292
            :|:||||||||||||::|:||..|:.::
Zfish   272 VAASQNKVYLSADSLVMNLQDDSFNKLS 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phb2	NP_001097372.1	SPFH_prohibitin	42..236	CDD:259799	153/194 (79%)
phb2b	NP_001002681.2	SPFH_prohibitin	49..243	CDD:259799	153/193 (79%)
phb2b	NP_001002681.2	PHB	49..209	CDD:214581	125/159 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580328
Domainoid	1	1.000	283	1.000	Domainoid score	I1609
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5263
Inparanoid	1	1.050	417	1.000	Inparanoid score	I1790
OMA	1	1.010	-	-		QHG63567
OrthoDB	1	1.010	-	-		D1089994at2759
OrthoFinder	1	1.000	-	-		FOG0002111
OrthoInspector	1	1.000	-	-		otm26012
orthoMCL	1	0.900	-	-		OOG6_101763
Panther	1	1.100	-	-	LDO	PTHR23222
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2721
SonicParanoid	1	1.000	-	-		X1399
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800