DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phb2 and Nphs2

DIOPT Version :9

Sequence 1:	NP_001097372.1	Gene:	Phb2 / 46038	FlyBaseID:	FBgn0010551	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_570841.3	Gene:	Nphs2 / 170672	RGDID:	620461	Length:	383	Species:	Rattus norvegicus

Alignment Length:	293	Identity:	68/293 - (23%)
Similarity:	123/293 - (41%)	Gaps:	59/293 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PPGLGI--GLKVLAA----VGAAAYGVSQSLYTVEGGHRAIIFSRLGG-IQSDIYSEGLHVRIPW 75
            |.|||.  .|.||::    :....:.:...:..|:...|.||| |||. :.......||...:|.
  Rat    95 PSGLGACEWLLVLSSLIFIIVTFPFSIWFCIKVVQEYERVIIF-RLGHLLPGRAKGPGLFFFLPC 158

  Fly    76 FQYPIIYDIRSRPRKIS-SPTGSKDLQMINISLRVLSRPDSLNLPYLHKQLGVDYDEKVLPSICN 139
            .......|:|.:..:|. ....:||:.::.|......|.::.:|  |...|.  :..|.:..:..
  Rat   159 LDTYHKVDLRLQTLEIPFHEVVTKDMFIMEIDAVCYYRMENASL--LLSSLA--HVSKAIQFLVQ 219

  Fly   140 EVLKSVIAKFNASQLITQRQQVSLLIRKELVERARDFNIILDDVSL--------TE-----LSFG 191
            ..:|.::|..:.::::.:|:.:           |:|..:.||.|:.        ||     |..|
  Rat   220 TTMKRLLAHRSLTEILLERKSI-----------AQDVKVALDSVTCVWGIKVERTEIKDVRLPAG 273

  Fly   192 KEYTAAIEAKQVAQQEAQRAVFFVERAKQEKQQKIVQAEGEAEAAKMLGLA---VKQNPAYLKLR 253
            .:::.|:||      ||||          :.:.:::.||||..|::.|.:|   :...||.::||
  Rat   274 LQHSLAVEA------EAQR----------QAKVRVIAAEGEKAASESLRMAAEILSGTPAAVQLR 322

  Fly   254 KLRAAQSIARTIASSQNKVYLSADSLMLNIQDS 286
            .|...||::   ....:.|.|.....|||:..|
  Rat   323 YLHTLQSLS---TDKPSTVVLPLPFDMLNLLSS 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phb2	NP_001097372.1	SPFH_prohibitin	42..236	CDD:259799	45/208 (22%)
Nphs2	NP_570841.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73
		SPFH_podocin	122..344	CDD:259809	57/256 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900