DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phb2 and Nphs2

DIOPT Version :9

Sequence 1:	NP_001097372.1	Gene:	Phb2 / 46038	FlyBaseID:	FBgn0010551	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_569723.1	Gene:	Nphs2 / 170484	MGIID:	2157018	Length:	385	Species:	Mus musculus

Alignment Length:	339	Identity:	75/339 - (22%)
Similarity:	132/339 - (38%)	Gaps:	91/339 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PPGLGI--GLKVLAA----VGAAAYGVSQSLYTVEGGHRAIIFSRLGG-IQSDIYSEGLHVRIPW 75
            |.|||.  .|.|||:    :....:.:...:..|:...|.||| |||. :.......||...:|.
Mouse    97 PSGLGACEWLLVLASLIFIIMTFPFSIWFCIKVVQEYERVIIF-RLGHLLPGRAKGPGLFFFLPC 160

  Fly    76 FQYPIIYDIRSRPRKIS-SPTGSKDLQMINISLRVLSRPDSLNLPYLHKQLGVDYDEKVLPSICN 139
            .......|:|.:..:|. ....:||:.::.|......|.::.:|  |...|.  :..|.:..:..
Mouse   161 LDTYHKVDLRLQTLEIPFHEVVTKDMFIMEIDAVCYYRMENASL--LLSSLA--HVSKAIQFLVQ 221

  Fly   140 EVLKSVIAKFNASQLITQRQQVSLLIRKELVERARDFNIILDDVSL--------TE-----LSFG 191
            ..:|.::|..:.::::.:|:.:           |:|..:.||.|:.        ||     |..|
Mouse   222 TTMKRLLAHRSLTEILLERKSI-----------AQDVKVALDAVTCIWGIKVERTEIKDVRLPAG 275

  Fly   192 KEYTAAIEAKQVAQQEAQRAVFFVERAKQEKQQKIVQAEGEAEAAKMLGLA---VKQNPAYLKLR 253
            .:::.|:||      ||||          :.:.:::.||||..|::.|.:|   :...||.::||
Mouse   276 LQHSLAVEA------EAQR----------QAKVRVIAAEGEKAASESLRMAAEILSGTPAAVQLR 324

  Fly   254 KLRAAQSIARTIASSQNKVYLSADSLMLNIQDSGFDDMTEKVYKIGTGLPKDWLDARKMASKVAQ 318
            .|...||::                             |||...:...||.|      |.|.::.
Mouse   325 YLHTLQSLS-----------------------------TEKPATVVLPLPFD------MLSLLSS 354

  Fly   319 PAEKEKNVGNVASS 332
            |..:.:...|..||
Mouse   355 PGNRAQGSINYPSS 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phb2	NP_001097372.1	SPFH_prohibitin	42..236	CDD:259799	45/208 (22%)
Nphs2	NP_569723.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		SPFH_podocin	124..346	CDD:259809	59/282 (21%)
		PHB	125..289	CDD:214581	41/195 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..385		3/12 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900