Protein Alignment nec and SERPINF1

DIOPT Version :10

• Sequence 1: NP_524851.1
• Gene: nec / 45908
• FlyBaseID: FBgn0002930
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: NP_002606.3
• Gene: SERPINF1 / 5176
• HGNCID: 8824
• Length: 418
• Species: Homo sapiens
• Alignment Length: 437
• Identity: 96/437 - (21%)
• Similarity: 182/437 - (41%)
• Gaps: 96/437 - (21%)

  Fly    90 REPVTPPPNRPP-------------PVF--------SYMDRFSSELFKEIIKSQSQQNVVFSPFS 133
            :.|.:||....|             |.|        :.:..|..:|::....:....||:.||.|
Human    20 QNPASPPEEGSPDPDSTGALVEEEDPFFKVPVNKLAAAVSNFGYDLYRVRSSTSPTTNVLLSPLS 84

  Fly   134 V-HALLALIYGASDGKTFRELQKAGEFSKNAMAVAQDFESVIKYKKHLEGA-----DLTLATKVY 192
            | .||.||..|| :.:|...:.:|..:.   :..:.|....  ||:.|:..     :|..|:::.
Human    85 VATALSALSLGA-EQRTESIIHRALYYD---LISSPDIHGT--YKELLDTVTAPQKNLKSASRIV 143

  Fly   193 YNREL-------GGVNHSYDEYAKFYFSAGTEAVDMQNAKDTAAKINAWVMDTTRNKIRDLVTPT 250
            :.::|       ..:..||....:..  .|...:|:|       :||.||....:.|:..  :..
Human   144 FEKKLRIKSSFVAPLEKSYGTRPRVL--TGNPRLDLQ-------EINNWVQAQMKGKLAR--STK 197

  Fly   251 DVDPQTQALLVNAVYFQGRWEHEFATMDTSPYDFQHTNGRISKVAMMFNDDV---YGL------- 305
            ::..:...||:...:|:|:|..:|.:..||..||.....|..:|.||.:...   |||
Human   198 EIPDEISILLLGVAHFKGQWVTKFDSRKTSLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCK 262

  Fly   306 -AELPELGATALELAYKDSATSMLILLPNETTGLGKMLQQLSRPEF--DLNRVAHRLRRQSVAVR 367
             |:||..|           :.|::..||.:.|....::::....||  |::|   .|:.....:.
Human   263 IAQLPLTG-----------SMSIIFFLPLKVTQNLTLIEESLTSEFIHDIDR---ELKTVQAVLT 313

  Fly   368 LPKFQFEFEQDMTEPLKNLGVHQMFTPNSQVTKLMDQPVRVSKILQKAYINVGE--AGTEASAAS 430
            :||.:..:|.::|:.|:.:.:..:| .:...:|:..:|::::::..:|.....|  |||..|.
Human   314 VPKLKLSYEGEVTKSLQEMKLQSLF-DSPDFSKITGKPIKLTQVEHRAGFEWNEDGAGTTPSP-- 375

  Fly   431 YAKFVPLSLPPK----PTEFVANRPFVFAVR--TPASVLFIGHVEYP 471
                   .|.|.    |.::..|:||:|.:|  ...::||||.:..|
Human   376 -------GLQPAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDP 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nec	NP_524851.1	serpin42Dd-like_insects	105..471	CDD:381070	89/399 (22%)
SERPINF1	NP_002606.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..39		4/18 (22%)
		serpinF1_PEDF	41..413	CDD:381008	91/412 (22%)
		O-glycosylated at one site	371..383		4/20 (20%)