Protein Alignment lds and Hltf

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001426368.1
• Gene: Hltf / 295568
• RGDID: 1309031
• Length: 1018
• Species: Rattus norvegicus
• Alignment Length: 899
• Identity: 244/899 - (27%)
• Similarity: 351/899 - (39%)
• Gaps: 321/899 - (35%)

  Fly   389 KPVYTGAQGMATFNNQKALTLESLK-DLHVSLEDLPGPE--VLAEDPVGLKVSLMNHQKHALAWM 450
            :||:...|          :|.|.|| :.....|||...:  :..|....::..|:.|||.|||||
  Rat   197 RPVHVAVQ----------MTTEQLKTEFDKLFEDLKEDDRTIEMEPAEAVETPLLPHQKQALAWM 251

  Fly   451 SWRE--RKLP--------------------------RGGILADDMGLGKTLTMISSVLA------ 481
            ..||  ::||                          .|||||||||||||||.|:.:|.
  Rat   252 IARENSKELPPFWELRNDLYYNTITNFSVKERPENVHGGILADDMGLGKTLTAIAVILTNFDDGR 316

  Fly   482 ---CKNGQEMSEGK----------------------------DESSDSDSEDDKN---------K 506
               .|.|:|...||                            :|.|.||..:..|         |
  Rat   317 PLLGKRGKESHPGKEYKDETVKLRGSNTNKTTDGHSEPSACSEEPSISDVSEKSNVSDLFSFFSK 381

  Fly   507 KRK----------------SVTGWKSKG-------------------RKDT-------------- 522
            :||                |....|.||                   ::||
  Rat   382 RRKISVQSTESSESEEIETSKLSQKMKGKLKNTQLDTKSKVKGSSKIKEDTQFALALTYFGPATK 446

  Fly   523 ---------------------RRGGTLVVCPASLLRQW-----------------------ESEV 543
                                 |...||::||.|:|..|                       :|||
  Rat   447 KKMLKKGTSVMESSKKCDTGERTRTTLIICPLSVLSNWILFSLISLRFFMKYTQDQIGQHIKSEV 511

  Fly   544 ESKVSRQKLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVAREH--KSLSAVFGVKWRRIILDEAH 606
            :       |.:.|::|.:|.....:|...||::|||.|:..::  |..|.:..:||.|:||||.|
  Rat   512 D-------LNLYVYYGPDRIRDSTWLSKQDIILTTYNILTHDYGTKDNSPLHSIKWLRVILDEGH 569

  Fly   607 VVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNK---- 667
            .:||..:|.:.||.:|..:.||.||||||||...|:::||.||:..||.|...|.:.|...
  Rat   570 AIRNPNAQQTKAVLELEAERRWVLTGTPIQNSLKDLWSLLSFLKLKPFTDREWWHRIIQRPVTTG 634

  Fly   668 SAGGQNRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFA 732
            ..||..||..|:||:.|||||........:..||.:::.:..|:|..||..:||:|....:...|
  Rat   635 DEGGLRRLQSLIKSITLRRTKTSKIKGKPVLELPERKVFIQHITLSVEERKIYQSVKNEGKATIA 699

  Fly   733 QFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSH--DILVLLLRL 795
            ::.                                           ::..|.:|  |:|.|||||
  Rat   700 RYF-------------------------------------------TEGTVLAHYADVLGLLLRL 721

  Fly   796 RQICCHPGLIDAMLDGEESQTMGDHSSD---SDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDD 857
            ||||||..|          .|.|..|||   |||||     :|.|:.:|.     .:.:.::|.|
  Rat   722 RQICCHVHL----------PTNGTSSSDPSRSDTPE-----ELRKMLVTK-----MKLILSSGSD 766

  Fly   858 GPPLLPDEARIAKASK------------------NLLKRSNP-------VFNLH----------- 886
                  :|..|...|.                  .:::|..|       ..|:|
  Rat   767 ------EECSICLDSLTFPVITHCAHVFCKPCICQVIQREQPHAKCPLCRSNIHGHNLLECPPEE 825

  Fly   887 -------------RPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSL 938
                         ..|||||.::..|.....|..:.|::||||:|:.|.::...|...|.....|
  Rat   826 LACDSDNKSDMEWTSSSKINALMNALIELRTKDPNIKSLVVSQFTTFLSLIETPLKASGFVFTRL 890

  Fly   939 NGTIPVKNRQDIVNEF-NDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRI 1002
            :|::..|.|.:.:..| |.......::||||.||||||||..|:.:.|:|..|||..|.|..||.
  Rat   891 DGSMAQKKRVESIQCFQNTDAGSPTIMLLSLKAGGVGLNLCAASRVFLMDPAWNPAAEDQCFDRC 955

  Fly  1003 YRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVSSKLTIDDLK 1056
            :|:|||:.|||.||:..|:||:.:..:|:.|.:||.|.. |.|   |...|::|
  Rat   956 HRLGQKQEVIITKFIVKDSVEENMLKIQNMKRELAAGAF-GTK---KTDADEMK 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	239/882 (27%)
		DEXHc_TTF2	439..686	CDD:350830	115/419 (27%)
Hltf	NP_001426368.1	None