DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lds and Hltf

DIOPT Version :9

Sequence 1:	NP_524850.2	Gene:	lds / 45894	FlyBaseID:	FBgn0002542	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_006232237.1	Gene:	Hltf / 295568	RGDID:	1309031	Length:	1018	Species:	Rattus norvegicus

Alignment Length:	899	Identity:	244/899 - (27%)
Similarity:	351/899 - (39%)	Gaps:	321/899 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 KPVYTGAQGMATFNNQKALTLESLK-DLHVSLEDLPGPE--VLAEDPVGLKVSLMNHQKHALAWM 450
            :||:...|          :|.|.|| :.....|||...:  :..|....::..|:.|||.|||||
  Rat   197 RPVHVAVQ----------MTTEQLKTEFDKLFEDLKEDDRTIEMEPAEAVETPLLPHQKQALAWM 251

  Fly   451 SWRE--RKLP--------------------------RGGILADDMGLGKTLTMISSVLA------ 481
            ..||  ::||                          .|||||||||||||||.|:.:|.
  Rat   252 IARENSKELPPFWELRNDLYYNTITNFSVKERPENVHGGILADDMGLGKTLTAIAVILTNFDDGR 316

  Fly   482 ---CKNGQEMSEGK----------------------------DESSDSDSEDDKN---------K 506
               .|.|:|...||                            :|.|.||..:..|         |
  Rat   317 PLLGKRGKESHPGKEYKDETVKLRGSNTNKTTDGHSEPSACSEEPSISDVSEKSNVSDLFSFFSK 381

  Fly   507 KRK----------------SVTGWKSKG-------------------RKDT-------------- 522
            :||                |....|.||                   ::||
  Rat   382 RRKISVQSTESSESEEIETSKLSQKMKGKLKNTQLDTKSKVKGSSKIKEDTQFALALTYFGPATK 446

  Fly   523 ---------------------RRGGTLVVCPASLLRQW-----------------------ESEV 543
                                 |...||::||.|:|..|                       :|||
  Rat   447 KKMLKKGTSVMESSKKCDTGERTRTTLIICPLSVLSNWILFSLISLRFFMKYTQDQIGQHIKSEV 511

  Fly   544 ESKVSRQKLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVAREH--KSLSAVFGVKWRRIILDEAH 606
            :       |.:.|::|.:|.....:|...||::|||.|:..::  |..|.:..:||.|:||||.|
  Rat   512 D-------LNLYVYYGPDRIRDSTWLSKQDIILTTYNILTHDYGTKDNSPLHSIKWLRVILDEGH 569

  Fly   607 VVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNK---- 667
            .:||..:|.:.||.:|..:.||.||||||||...|:::||.||:..||.|...|.:.|...
  Rat   570 AIRNPNAQQTKAVLELEAERRWVLTGTPIQNSLKDLWSLLSFLKLKPFTDREWWHRIIQRPVTTG 634

  Fly   668 SAGGQNRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFA 732
            ..||..||..|:||:.|||||........:..||.:::.:..|:|..||..:||:|....:...|
  Rat   635 DEGGLRRLQSLIKSITLRRTKTSKIKGKPVLELPERKVFIQHITLSVEERKIYQSVKNEGKATIA 699

  Fly   733 QFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSH--DILVLLLRL 795
            ::.                                           ::..|.:|  |:|.|||||
  Rat   700 RYF-------------------------------------------TEGTVLAHYADVLGLLLRL 721

  Fly   796 RQICCHPGLIDAMLDGEESQTMGDHSSD---SDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDD 857
            ||||||..|          .|.|..|||   |||||     :|.|:.:|.     .:.:.::|.|
  Rat   722 RQICCHVHL----------PTNGTSSSDPSRSDTPE-----ELRKMLVTK-----MKLILSSGSD 766

  Fly   858 GPPLLPDEARIAKASK------------------NLLKRSNP-------VFNLH----------- 886
                  :|..|...|.                  .:::|..|       ..|:|
  Rat   767 ------EECSICLDSLTFPVITHCAHVFCKPCICQVIQREQPHAKCPLCRSNIHGHNLLECPPEE 825

  Fly   887 -------------RPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSL 938
                         ..|||||.::..|.....|..:.|::||||:|:.|.::...|...|.....|
  Rat   826 LACDSDNKSDMEWTSSSKINALMNALIELRTKDPNIKSLVVSQFTTFLSLIETPLKASGFVFTRL 890

  Fly   939 NGTIPVKNRQDIVNEF-NDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRI 1002
            :|::..|.|.:.:..| |.......::||||.||||||||..|:.:.|:|..|||..|.|..||.
  Rat   891 DGSMAQKKRVESIQCFQNTDAGSPTIMLLSLKAGGVGLNLCAASRVFLMDPAWNPAAEDQCFDRC 955

  Fly  1003 YRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVSSKLTIDDLK 1056
            :|:|||:.|||.||:..|:||:.:..:|:.|.:||.|.. |.|   |...|::|
  Rat   956 HRLGQKQEVIITKFIVKDSVEENMLKIQNMKRELAAGAF-GTK---KTDADEMK 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	SNF2_N	442..805	CDD:278600	143/537 (27%)
		DEXDc	459..634	CDD:238005	79/315 (25%)
		HELICc	885..1014	CDD:238034	51/153 (33%)
Hltf	XP_006232237.1	HIRAN	60..155	CDD:285949
		DEXDc	238..>316	CDD:214692	30/77 (39%)
		SNF2_N	472..727	CDD:278600	92/304 (30%)
		DEXDc	<472..597	CDD:238005	42/131 (32%)
		RING	768..813	CDD:238093	5/44 (11%)
		Helicase_C	841..959	CDD:278689	45/117 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920