Protein Alignment bel and DDX50

DIOPT Version :10

• Sequence 1: NP_001262379.1
• Gene: bel / 45826
• FlyBaseID: FBgn0263231
• Length: 801
• Species: Drosophila melanogaster
• Sequence 2: NP_076950.1
• Gene: DDX50 / 79009
• HGNCID: 17906
• Length: 737
• Species: Homo sapiens
• Alignment Length: 748
• Identity: 186/748 - (24%)
• Similarity: 284/748 - (37%)
• Gaps: 206/748 - (27%)

  Fly   179 SNLNEQTAEDGQAQQQQQPRNDRWQEPERPAGFDGSEGGQSAGGNRSYNNRGERGGGGYNSRWKE 243
            |:...:|.|:|.......|:..:.:..|:..| |..||         :|...:.....:.||.|:
Human    41 SDEKSETRENGVTDDLDAPKAKKSKMKEKLNG-DTEEG---------FNRLSDEFSKSHKSRRKD 95

  Fly   244 GGGSNVD-YTKLGARDERLEVELFGVGNTGINFDKYEDIPVEATGQNVPPNIT------SFDDVQ 301
            ....::| |.|...|          |.:...:..|..|..:|.|       :|      :|.:..
Human    96 LPNGDIDEYEKKSKR----------VSSLDTSTHKSSDNKLEET-------LTREQKEGAFSNFP 143

  Fly   302 LTEIIRNNVALARYDKPT---PVQKHAIPIIINGRDLMACAQTGSGKTAAFLVPILNQMYELGHV 363
            ::|   ..:.|.:....|   |:|......:..|:||:|.|:||:|||.:|.:|::.::
Human   144 ISE---ETIKLLKGRGVTYLFPIQVKTFGPVYEGKDLIAQARTGTGKTFSFAIPLIERL------ 199

  Fly   364 PPPQSTRQYSRRKQYPLGLVLAPTRELATQIFEEAKKFAYRSRMRPAVLYGGNNTSEQMRELDRG 428
               |..::..::.:.|..||||||||||.|:.::.|...  .::..|..|||.:...|:..:..|
Human   200 ---QRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDIT--RKLSVACFYGGTSYQSQINHIRNG 259

  Fly   429 CHLIVATPGRLEDMITRGKVGLENIRFLVLDEADRMLDMGFEPQIRRIV-EQLNMPPTGQRQTLM 492
            ..::|.||||::|.:..|::.|..:|.:||||.|:|||:||..|:..|: |..........|||:
Human   260 IDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLDLGFAEQVEDIIHESYKTDSEDNPQTLL 324

  Fly   493 FSATFPKQIQELASDFLSNYIFLAVGRVGSTSENITQTI-------LWVYEPDKRSYLLDLLSSI 550
            ||||.|:.:.::|..::.:. :..|..||..::....|:       .|...|.....:|.:.|.
Human   325 FSATCPQWVYKVAKKYMKSR-YEQVDLVGKMTQKAATTVEHLAIQCHWSQRPAVIGDVLQVYSG- 387

  Fly   551 RDGPEYTKDSLTLIFVETKKGADSLEEFLY-----QCNHPVTSIHGDRTQKEREEALRCFRSGDC 610
                   .:...:||.||||....:....:     ||      :|||..|.:||..|:.||.|..
Human   388 -------SEGRAIIFCETKKNVTEMAMNPHIKQNAQC------LHGDIAQSQREITLKGFREGSF 439

  Fly   611 PILVATAVAARGLDIPHVKHVINFDLPSDVEEYVHRIGRTGRMGNLGVATSFFNEKNRN------ 669
            .:||||.|||||||||.|..||....|.|||.|:||.|||||.|..|:...|:..:.|.
Human   440 KVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICICFYQPRERGQLRYVE 504

  Fly   670 -------------ICSDLL--------------------------ELLIETKQEIPSFMEDM--- 692
                         ...||:                          :.|||.|..:.:....:
Human   505 QKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSYAAVDFFRPSAQRLIEEKGAVDALAAALAHI 569

  Fly   693 ------------SSDRG---------------------------HGGAKRAGR-----GGGG--- 710
                        :||:|                           .....:..|     |..|
Human   570 SGASSFEPRSLITSDKGFVTMTLESLEEIQDVSCAWKELNRKLSSNAVSQITRMCLLKGNMGVCF 634

  Fly   711 -------------------------------RYGGGFGSRDYRQSSGGGGGGRSGPPPRSGGSGS 744
                                           .|..|..|.:.||.| |...||||...||||...
Human   635 DVPTTESERLQAEWHDSDWILSVPAKLPEIEEYYDGNTSSNSRQRS-GWSSGRSGRSGRSGGRSG 698

  Fly   745 GGGGGSYRSNGNSYGKFGGNSGGGGYYGGGAGG 777
            |..|...|....|..:..|....|......:||
Human   699 GRSGRQSRQGSRSGSRQDGRRRSGNRNRSRSGG 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bel	NP_001262379.1	DEADc_DDX3	275..522	CDD:350809	76/256 (30%)
		SF2_C_DEAD	527..663	CDD:350174	53/147 (36%)
DDX50	NP_076950.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..131		23/116 (20%)
		Q motif	137..165		5/30 (17%)
		SrmB	139..526	CDD:440279	129/415 (31%)
		DEVD box	290..293		2/2 (100%)
		GUCT_RHII_Gualpha_beta	568..659	CDD:240593	6/90 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	668..737		22/65 (34%)