Protein Alignment bel and DDX53

DIOPT Version :10

• Sequence 1: NP_001262379.1
• Gene: bel / 45826
• FlyBaseID: FBgn0263231
• Length: 801
• Species: Drosophila melanogaster
• Sequence 2: NP_874358.2
• Gene: DDX53 / 168400
• HGNCID: 20083
• Length: 631
• Species: Homo sapiens
• Alignment Length: 638
• Identity: 185/638 - (28%)
• Similarity: 289/638 - (45%)
• Gaps: 152/638 - (23%)

  Fly   148 GGDWNRSGGGGGGGRG-FG-RGPSYRGGG-----------------GGSGSNLNEQTAEDGQAQQ 193
            |..|:..|..|.|..| || :||...|..                 |.|||.:.:
Human    19 GASWDVRGSRGSGWSGPFGHQGPRAAGSREPPLCFKIKNNMVGVVIGYSGSKIKD---------- 73

  Fly   194 QQQPRNDRWQEPERPAGFDG-SEGGQSAGGNRSYNNRGE-------RGGGGYNSRWKEGGGSNVD 250
            .|...|.:.|.      .:| ||......|||....:.:       |....|||.      |:||
Human    74 LQHSTNTKIQI------INGESEAKVRIFGNREMKAKAKAAIETLIRKQESYNSE------SSVD 126

  Fly   251 YT--------KLGARDERLEVELFGVGNTGINFDKYEDIPVEATGQ---NVPP------------ 292
            ..        .||..|      :.|......|:|:.....||...:   ::||
Human   127 NAASQTPIGRNLGRND------IVGEAEPLSNWDRIRAAVVECEKRKWADLPPVKKNFYIESKAT 185

  Fly   293 ----------------NITSFDDVQ------------------------LTEIIRNNVALARYDK 317
                            |||. ||::                        |..|||..:.     |
Human   186 SCMSEMQVINWRKENFNITC-DDLKSGEKRLIPKPTCRFKDAFQQYPDLLKSIIRVGIV-----K 244

  Fly   318 PTPVQKHAIPIIINGRDLMACAQTGSGKTAAFLVPILNQMYELG--HVPPPQSTRQYSRRKQYPL 380
            |||:|..|.|||:.|.||:..||||:|||.::|:|        |  |:.....:|:   ::..|.
Human   245 PTPIQSQAWPIILQGIDLIVVAQTGTGKTLSYLMP--------GFIHLDSQPISRE---QRNGPG 298

  Fly   381 GLVLAPTRELATQIFEEAKKFAYRSRMRPAVLYGGNNTSEQMRELDRGCHLIVATPGRLEDMITR 445
            .|||.||||||..:..|..|::|:. ::...:|||.|.:.|:.::.:|..:|:||||||.|:...
Human   299 MLVLTPTRELALHVEAECSKYSYKG-LKSICIYGGRNRNGQIEDISKGVDIIIATPGRLNDLQMN 362

  Fly   446 GKVGLENIRFLVLDEADRMLDMGFEPQIRRIVEQLNMPPTGQRQTLMFSATFPKQIQELASDFLS 510
            ..|.|.:|.:||:||||:||||.||||||:|:  |::.|  .|||:|.|||:|..:::||..:|.
Human   363 NSVNLRSITYLVIDEADKMLDMEFEPQIRKIL--LDVRP--DRQTVMTSATWPDTVRQLALSYLK 423

  Fly   511 NYIFLAVGRVGSTSEN-ITQTILWVYEPDKRSYLLDLLSSIRDGPEYTKDSLTLIFVETKKGADS 574
            :.:.:.||.:...:.| :.|.|:...|.:||:...:.:.::      :.:...::||..|..||.
Human   424 DPMIVYVGNLNLVAVNTVKQNIIVTTEKEKRALTQEFVENM------SPNDKVIMFVSQKHIADD 482

  Fly   575 LEEFLYQCNHPVTSIHGDRTQKEREEALRCFRSGDCPILVATAVAARGLDIPHVKHVINFDLPSD 639
            |............|:||:..|.::|.|:..|:||:..||:.|.:.:||||:..|.||.|:|.|.:
Human   483 LSSDFNIQGISAESLHGNSEQSDQERAVEDFKSGNIKILITTDIVSRGLDLNDVTHVYNYDFPRN 547

  Fly   640 VEEYVHRIGRTGRMGNLGVATSFFNEKNRNICSDLLELLIETKQEIPSFMEDM 692
            ::.||||:|..||.|..|.:.:...:::..:..:|:::|....|.:|   ||:
Human   548 IDVYVHRVGYIGRTGKTGTSVTLITQRDSKMAGELIKILDRANQSVP---EDL 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bel	NP_001262379.1	DEADc_DDX3	275..522	CDD:350809	100/303 (33%)
		SF2_C_DEAD	527..663	CDD:350174	42/135 (31%)
DDX53	NP_874358.2	KH-I_DDX43_DDX53	50..115	CDD:411858	13/80 (16%)
		Q motif	222..250		8/32 (25%)
		SrmB	231..625	CDD:440279	139/397 (35%)
		DEAD box	376..379		2/2 (100%)