DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Abl and TYK2

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_001372133.1 Gene:TYK2 / 7297 HGNCID:12440 Length:1257 Species:Homo sapiens


Alignment Length:371 Identity:117/371 - (31%)
Similarity:176/371 - (47%) Gaps:75/371 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   332 TQEAKFNT-LAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHK- 394
            ||...|.| |.:|....  ||....::|  :.|....:.||||                   || 
Human   924 TQRPSFRTILRDLTRLQ--PHNLADVLT--VNPDSPASDPTVF-------------------HKR 965

  Fly   395 -------LGGGQYGEV----YEAVWKRYGNTVAVKTLKED--TMALKDFLEEAAIMKEMKHPNLV 446
                   ||.|.:|:|    |:......|..||||.||.|  ......:.:|..|::.:.|.:::
Human   966 YLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII 1030

  Fly   447 QLIGVC--TREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHR 509
            :..|.|  ..|....::.|::..|:|.|:|   .|.::....||..|.||..||:||.:::||||
Human  1031 KYKGCCEDQGEKSLQLVMEYVPLGSLRDYL---PRHSIGLAQLLLFAQQICEGMAYLHAQHYIHR 1092

  Fly   510 DLAARNCLVGDNKLVKVADFGLARLMRD--DTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAF 572
            ||||||.|:.:::|||:.|||||:.:.:  :.|........|:.|.|||.|...||...||||:|
Human  1093 DLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSF 1157

  Fly   573 GVLLWEIATY---GMSP--------------YPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMR 620
            ||.|:|:.|:   ..||              ...:.||::   |::|.|:.||..||.|||.||:
Human  1158 GVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTEL---LERGERLPRPDKCPCEVYHLMK 1219

  Fly   621 QCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQLNANATSASS 666
            .||:.:|:.||||:::          ..|.:.|.::....|.|..|
Human  1220 NCWETEASFRPTFENL----------IPILKTVHEKYQGQAPSVFS 1255

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784
SH2_ABL 268..363 CDD:198189 9/31 (29%)
PTKc_Abl 382..644 CDD:270645 98/296 (33%)
FABD 1584..1723 CDD:197885
TYK2NP_001372133.1 FERM_F1 28..125 CDD:465733
FERM_F2 143..266 CDD:436450
Jak1_Phl 285..432 CDD:465552
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..366
SH2 437..534 CDD:472789
Protein Kinases, catalytic domain 589..937 CDD:473864 5/12 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..629
PTKc_Tyk2_rpt2 962..1244 CDD:270664 101/316 (32%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.