DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Abl and csk

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_001071067.1 Gene:csk / 556454 ZFINID:ZDB-GENE-061103-493 Length:450 Species:Danio rerio


Alignment Length:443 Identity:174/443 - (39%)
Similarity:263/443 - (59%) Gaps:28/443 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   211 VALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHS---- 271
            ||.|:|....:..|.:.||:.:.|:...|...|..|.:.:|..|.:|:|||.....::..|    
Zfish    15 VARYNFPGTADQDLPMCKGDVLTIVGVTKDPNWYRAKNSAGREGTIPANYVQKREGVKSASKLSL 79

  Fly   272 --WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQE 334
              |:||.|:|..||.||.....|.||||||.:.||..::.:..:|:|.||||... :||:.:.:|
Zfish    80 MPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIIYH-NGKLSIDEE 143

  Fly   335 AKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDE-----WEICRTDIMMKHK 394
            ..|..|.:|:.|::  .:..||.|.|:  .||..:.||    ...||     |.:.|.::.:...
Zfish   144 EYFENLMQLMEHYT--KDADGLCTRLI--KPKIMEGTV----AAQDEFSRSGWALNRKELKLIQT 200

  Fly   395 LGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREP-PF 458
            :|.|::|:|....::  |..||||.:|.|..| :.|:.||::|.:::|.|||||:||...|. ..
Zfish   201 IGKGEFGDVMVGDYR--GKKVAVKCIKHDATA-QAFVAEASVMTQLRHNNLVQLLGVIVEEKGSL 262

  Fly   459 YIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKL 523
            ||:||:|:.|:|:|:|||.||..:....|:..:..:...|.|||:.|::||||||||.||.::.:
Zfish   263 YIVTEYMAKGSLVDYLRSRGRTVIGGDRLINFSMDVCKAMEYLEANNFVHRDLAARNVLVSEDNI 327

  Fly   524 VKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYP 588
            .||:||||.:    :..:....||.|:|||:||.|...|||||||||::|:|||||.::|..|||
Zfish   328 AKVSDFGLTK----EASSTQDTAKLPVKWTSPEALREKKFSTKSDVWSYGILLWEIYSFGRVPYP 388

  Fly   589 AIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALE 641
            .|.|.:|..:::|||:|:.|.||||.|||:|:|||..||..||:|:.:...|:
Zfish   389 RIPLKEVVPRVEKGYKMDSPDGCPPVVYDIMKQCWTLDAVVRPSFRDLREKLQ 441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 17/51 (33%)
SH2_ABL 268..363 CDD:198189 36/100 (36%)
PTKc_Abl 382..644 CDD:270645 115/261 (44%)
FABD 1584..1723 CDD:197885
cskNP_001071067.1 SH3_CSK 11..67 CDD:212703 17/51 (33%)
SH2_csk_like 78..175 CDD:198190 37/101 (37%)
PTKc_Csk 188..443 CDD:133213 115/261 (44%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.