Protein Alignment Abl and Blk

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: XP_006252250.1
• Gene: Blk / 364403
• RGDID: 1308859
• Length: 554
• Species: Rattus norvegicus
• Alignment Length: 498
• Identity: 206/498 - (41%)
• Similarity: 290/498 - (58%)
• Gaps: 46/498 - (9%)

  Fly   179 SSTTSVFESAHRWTSKE------------------NLLAPGPEE--DDPQLF-VALYDFQAGGEN 222
            ||...:.|.:..|:..:                  :|..|.|.:  |:.:.| |||:|:.|..:.
  Rat    60 SSKRQISEKSKSWSPVKARAQGKVPPPLPPLVVFNHLPPPSPNQHPDEEERFVVALFDYAAVNDR 124

  Fly   223 QLSLKKGEQVRILSYNKSGEWCEAHS-DSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLL 286
            .|.:.|||::::|  ..:|:|..|.| .:|..|:||||:|.|:.:||...|:...|||..||..|
  Rat   125 DLQVLKGEKLQVL--KSTGDWWLARSLVTGREGYVPSNFVAPVETLEVEKWFFRTISRKDAERQL 187

  Fly   287 SSGIN--GSFLVRESESSPGQRSISLR---YEGR-VYHYRISEDPDGKVFVTQEAKFNTLAELVH 345
            .:.:|  ||||:|||||:.|..|:|::   .:|. |.||:|....:|..:::....|.||..||.
  Rat   188 LAPMNKAGSFLIRESESNKGAFSLSVKDVTSQGEMVKHYKIRSLDNGGYYISPRITFPTLQALVQ 252

  Fly   346 HHSVPHEG--HGLITPLLYPAPKQNKPTVFPLSP-EPDEWEICRTDIMMKHKLGGGQYGEVYEAV 407
            |:|...:|  ..|..|.:.||||         :| ..|||||.|..:.:..|||.||:|||:...
  Rat   253 HYSEKGDGLCQKLTLPCVNPAPK---------NPWAQDEWEIPRQSLKLVRKLGSGQFGEVWMGY 308

  Fly   408 WKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLD 472
            :|. ...||:|||||.||:.:.||.||.:||.::|..||:|..|.||| |.||:||:|:.|.|||
  Rat   309 YKN-NMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVTRE-PIYIVTEYMARGCLLD 371

  Fly   473 FLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRD 537
            ||::.....|....|:.|:.|:|.||:|:|..|.|||||.|.|.||.:....|:|||||||:: |
  Rat   372 FLKTDEGSRLSLPRLIDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARII-D 435

  Fly   538 DTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKG 602
            ..|||..||||||||||||.:.:..|:.|:|||:|||||.||.|||..|||.:...:|...|:.|
  Rat   436 SEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEHG 500

  Fly   603 YRMERPPGCPPEVY-DLMRQCWQWDATDRPTFKSIHHALEHMF 644
            |||..|..||||:| |::.:||:....:||||:.:...||..:
  Rat   501 YRMPCPETCPPELYHDVITECWRGRPEERPTFEFLQSVLEDFY 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	22/55 (40%)
		SH2_ABL	268..363	CDD:198189	37/102 (36%)
		PTKc_Abl	382..644	CDD:270645	130/262 (50%)
		FABD	1584..1723	CDD:197885
Blk	XP_006252250.1	SH3	111..164	CDD:473055	22/54 (41%)
		SH2	169..268	CDD:472789	36/98 (37%)
		Protein Kinases, catalytic domain	282..545	CDD:473864	131/265 (49%)