Protein Alignment Abl and Map3k21

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_001418265.1
• Gene: Map3k21 / 307950
• RGDID: 1306091
• Length: 996
• Species: Rattus norvegicus
• Alignment Length: 1262
• Identity: 260/1262 - (20%)
• Similarity: 393/1262 - (31%)
• Gaps: 494/1262 - (39%)

  Fly   202 PEEDD-----PQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGW------ 255
            |..||     ..::.||||::|.||::||||:|:.|.:||.:.        :.||:.||
  Rat    16 PVRDDSGSSSSGMWAALYDYEARGEDELSLKRGQLVEVLSQDA--------AVSGDEGWWAGQVQ 72

  Fly   256 -----VPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGR 315
                 .|::||.|.:|:                               |..||
  Rat    73 RRLGIFPASYVAPCSSV-------------------------------SPPSP------------ 94

  Fly   316 VYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPD 380
                                                           |.|:       |.||...
  Rat    95 -----------------------------------------------PPPR-------PCSPVHV 105

  Fly   381 EWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKED-----TMALKDFLEEAAIMKEM 440
            ::|    .:.:|..:|.|.:|:||.|.|:  |..||||..:.|     ..|.:....||.:...:
  Rat   106 DFE----RLELKELIGAGGFGQVYRATWQ--GQEVAVKAARRDPEQDAAAAAESVRREARLFAML 164

  Fly   441 KHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRE----------TLDAVALLYMATQIA 495
            :|||::||.|||.::|...::.||...|.|...|.:|..:          .:....|:..|.|||
  Rat   165 RHPNIIQLRGVCLQQPHLCLVLEFARGGALNRALAAAAPDPRVPGPRRARRIPPHVLVNWAVQIA 229

  Fly   496 SGMSYLESRNYI---HRDLAARNCLVGD--------NKLVKVADFGLARLMRDDTYTAHAGAKFP 549
            .||.||.....:   ||||.:.|.|:.:        ||.:|:.||||||.....|..:.||.
  Rat   230 RGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTRMSAAGT--- 291

  Fly   550 IKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAID-LTDVYHKLDKGYRMERPPGCPP 613
            ..|.|||.:..:.||..||:|::||||||:.| |..||..|| |...|........:..|..||.
  Rat   292 YAWMAPEVIRSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPE 355

  Fly   614 EVYDLMRQCWQWDATDRPTF--------------------KSIHH-------ALEHMFQESSITE 651
            ....||::||:.|...||:|                    :|.|.       .::.||.|....|
  Rat   356 PFAKLMKECWEQDPHIRPSFALILKQLTAIEEAVLTDLPQESFHSMQEDWKLEIQQMFSELRTKE 420

  Fly   652 -------------------------------------AVEKQLNANATSASSSAPSTSGVATGGG 679
                                                 .:|::||......|..||.
  Rat   421 KELRSREEELSRAALQQKSQELLLRRREQQLAEREIDVLERELNVLIFQLSQEAPH--------- 476

  Fly   680 ATTTTAASGCASSSSATASLSLTPQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSETGSTSTKL 744
                                      |||  ..|:.........|.|  :.|.|
  Rat   477 --------------------------VKK--RKGRFRRGRLRLKDGH--RISLP----------- 500

  Fly   745 STFSSQGKGNVQMRRTTNKQ-----------GKQAPAPPKRTSLLSS-------SRDSTYREEDP 791
            |.|  |.|..||...|.:|:           |.....|..|...|:|       .|:..:|:||
  Rat   501 SDF--QHKITVQASPTLDKRRSSDSGLCSPPGSPLMLPRLRAIQLTSDENNKTRGRNVVFRQED- 562

  Fly   792 ANARCNFIDDLSTNGIHKLKTANYFSQTLSRNFKTQIPTHHTHQIRTQQQQQQQSVQQQQQIVPL 856
                                     .:.:.||||.:..|.....|:|:.:.     :.::::.||
  Rat   563 -------------------------FEVVKRNFKRKGCTWGPSSIQTKGRP-----EGRERVRPL 597

  Fly   857 SVQQQAHQQQQKQQQYSIKKSSSCSSFLYDILFRGLARDINSLTQRYDSETDPAADPDTDATGDS 921
            |                 ..:|..||.|           |.|      .:|.|.|....|..|..
  Rat   598 S-----------------DGNSPWSSLL-----------IKS------QKTTPLASLFVDQPGSC 628

  Fly   922 LEQSLSQVIAAPVTNKMQHSLHSGGGGGGIGPRSSQQHSSFKRPTGTPVMGNRGLETRQSKRSQL 986
            .||.|       |.:.::|.            :..|..|..:...|.|:.  :..:...|..::.
  Rat   629 EEQKL-------VPDGLEHK------------KPKQTKSPGQAYVGLPLC--KDSQREDSLEAES 672

  Fly   987 HSQAPGPGPPSTQPHHGNNGVVTSAHPITVGALDV-MNVKQVVNRYGTLPKGARIGAYLDSLEDS 1050
            ..:.|..|.|..                :|||..: ...:..:...|.|.....:|  ||..:..
  Rat   673 REEGPSKGSPVN----------------SVGAPFLKKKTESALCECGVLLASMALG--LDVRKLH 719

  Fly  1051 SEAAPALPATAPSLPPANGHATPPAARLNPKASPIPPQQMIRSNSSGGVTMQNNAAASLNK---- 1111
            ....|..|  :|........|....:|....:||:..|.......|.|.|:..:|.:.|:|
  Rat   720 GAQVPTKP--SPKDEKKGEGAVQLVSRCQTSSSPLLRQPSAGRAPSDGSTLLLSATSLLSKSSLS 782

  Fly  1112 ----LQRHRTTTEGTMMTFSSFRAGGSSSSPKRSASGVASGVQPAL------ANLEFPPPPL--- 1163
                ||   ...|...:..:....|.::.:|..|::...|.:.|.|      ..|...||.:
  Rat   783 MKCLLQ---AGEEEAPLGNTQVSCGPTTITPDPSSAAPESTLTPGLRLKADCGVLRSVPPAILEQ 844

  Fly  1164 ------------------------DLPPPPEEFEG--GPP-PPPPAPESAVQAIQQHLHAQLPNN 1201
                                    ::|..|:...|  ||| .|.|.|::
  Rat   845 TGERLPGCSTAGDKECHRVQMGSNEIPLRPQSAPGDYGPPHSPSPGPQT---------------- 893

  Fly  1202 GNISNGNGTNNNDSSHNDVSNIAPSVEEASSRF---------GVSLRKREPSTDSCSS------- 1250
                        |.:..| |.:.|.|.....:.         ..|||...|:..:|..
  Rat   894 ------------DLASQD-SPVQPQVVLGKCQACPAPPQRPQTASLRTTPPAAWACDKDHAVPAF 945

  Fly  1251 ---LGSPPEDLKEKLITEIKAAGKDTA 1274
               ||:......:.|.|.::...||.|
  Rat   946 ACFLGAQERSRCQVLDTSLEGQNKDRA 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	22/64 (34%)
		SH2_ABL	268..363	CDD:198189	3/94 (3%)
		PTKc_Abl	382..644	CDD:270645	96/315 (30%)
		FABD	1584..1723	CDD:197885
Map3k21	NP_001418265.1	SH3	28..84	CDD:473055	21/63 (33%)
		STKc_MLK4	115..385	CDD:271048	92/275 (33%)