DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and Tnni3k

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_861434.1 Gene:Tnni3k / 295531 RGDID:727908 Length:835 Species:Rattus norvegicus


Alignment Length:868 Identity:196/868 - (22%)
Similarity:304/868 - (35%) Gaps:269/868 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 VGLNIFTEHN----------GTKHSSFRGHPGKYHMNLEALLQSR------PLPHI----PAGST 146
            |.||..||..          |...|..|.      :.|:.|..||      |..|:    .:...
  Rat    58 VSLNYRTERGLSLLHLCCVCGGNKSHIRA------LMLKGLRPSRLTRNGFPALHLAVYKDSPEL 116

  Fly   147 AASLLADAAELQQHQQDSGGLGLQGSSLGGGHSSTTSVFESAHRWTSKENLLAPGPEED--DPQL 209
            ..|||...|::|  |...|||.....:...||.....|            ||..|...:  |...
  Rat   117 ITSLLHSGADVQ--QVGYGGLTALHIAAIAGHPEAAEV------------LLQHGANVNVQDAVF 167

  Fly   210 FVALYDFQAGGENQLS---LKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVT--------- 262
            |..|:.....|..|::   ||.|..|.:               ||.||..|.:..:         
  Rat   168 FTPLHIAAYYGHEQVTSVLLKFGADVNV---------------SGEVGDRPLHLASAKGFFNIVK 217

  Fly   263 ---------PLNSLEKHSWYHGPI---SR----NAAEYLLSSGI--------------------N 291
                     .:|:.:...  |.|:   ||    |...|||.|.:                    |
  Rat   218 LLVEEGSKADVNAQDNED--HVPLHFCSRFGHHNIVSYLLQSDLEVQPHVINIYGDTPLHLACYN 280

  Fly   292 GSF--------------LVRESESSP--------------------GQRSISLRYEGR------- 315
            |:|              |.:|:..|.                    .|.::::.:.||       
  Rat   281 GNFEVAKEIVQVTGTESLTKENIFSETAFHSACTYGKNIDLVKFLLDQNAVNINHRGRDGHTGLH 345

  Fly   316 --VYHYRI-------------------------SEDPDGKVFVTQEAKFNTLAELVHHHSVPHE- 352
              .||..|                         .:|....:....|...:.:..|:.|:..|.| 
  Rat   346 SACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQEE 410

  Fly   353 ----------GHGLITPLLYPAPK-----QNKPTVFPLSPE-PDEWEICRTDIMMKHKLGGGQYG 401
                      |.|....:..|..|     :.|..|..|..| |..:.:..::|.....:|.|.:|
  Rat   411 LPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADVLLLRAELPSRFHLQLSEIEFHEIIGSGSFG 475

  Fly   402 EVYEAVWKRYGNTVAVKTLKEDTMALKD----FLEEAAIMKEMKHPNLVQLIGVCTREP-PFYII 461
            :||:.  :.....||:|..:.:|...|.    |..|.:|:.::.||.:||.:|.|..:| .|.|:
  Rat   476 KVYKG--RCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGACLDDPSQFAIV 538

  Fly   462 TEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLES--RNYIHRDLAARNCLVGDNKLV 524
            |:::|.|:|...|....| .||..:.|.:|..:|.||.||.|  :..|||||.:.|.|:.::...
  Rat   539 TQYISGGSLFSLLHEQKR-ILDLQSKLIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILLYEDGHA 602

  Fly   525 KVADFGLARLMR---DDTYTAHAGAKFPIKWTAPEGLAY-NKFSTKSDVWAFGVLLWEIATYGMS 585
            .|||||.:|.::   :|..|...|   .::|.|||.... .:::.|:||:::.:.|||:.| |..
  Rat   603 VVADFGESRFLQSLDEDNMTKQPG---NLRWMAPEVFTQCTRYTIKADVFSYSLCLWELLT-GEI 663

  Fly   586 PY----PAIDLTDV-YHKLDKGYRMERPP---GCPPEVYDLMRQCWQWDATDRPTFKSIHHALEH 642
            |:    ||....|: ||.:       |||   ..|..:..|:.:.|......||.|..:...||.
  Rat   664 PFAHLKPAAAAADMAYHHI-------RPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVSKLEE 721

  Fly   643 MFQESSITEAVEKQLNANATSASSSAPSTSGVATGGGATTTTAASGCASSSSATASLSLTPQMVK 707
            ....      ||....|::.|:.|.:||:|              |.|               ::.
  Rat   722 CLCN------VELMSPASSNSSGSLSPSSS--------------SDC---------------LLS 751

  Fly   708 KGLPGGQALTPNAHHNDPHQQQASTPMSETGSTSTKLSTFSSQGKGNVQMRRTT-----NKQGKQ 767
            :|.||...:.  |..:....:.|....|..| .|..:.|.|:.|....:|.|:|     :|.| .
  Rat   752 RGGPGRSHVA--ALRSRFELEYALNARSYAG-WSQSVGTHSNPGLSLEEMNRSTQYSTVDKYG-Y 812

  Fly   768 APAPPKRTSLLSSSRDSTYREED 790
            ...|...|.|.|...||.:.:.:
  Rat   813 VSDPMSLTHLHSRQDDSNFEDSN 835

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 13/74 (18%)
SH2_ABL 268..363 CDD:198189 29/200 (15%)
PTKc_Abl 382..644 CDD:270645 84/280 (30%)
FABD 1584..1723 CDD:197885
Tnni3kNP_861434.1 ANK repeat 66..98 CDD:293786 7/37 (19%)
ANK 1 66..96 5/35 (14%)
ANKYR 86..372 CDD:440430 57/322 (18%)
ANK repeat 100..131 CDD:293786 8/32 (25%)
ANK 2 100..129 7/30 (23%)
ANK 3 133..162 9/40 (23%)
ANK repeat 134..164 CDD:293786 8/41 (20%)
ANK repeat 166..197 CDD:293786 8/45 (18%)
ANK 4 166..195 8/28 (29%)
ANK repeat 199..232 CDD:293786 4/32 (13%)
ANK 5 199..228 3/28 (11%)
ANK 6 234..263 9/30 (30%)
ANK repeat 234..262 CDD:293786 9/29 (31%)
ANK repeat 269..302 CDD:293786 4/32 (13%)
ANK 7 269..298 3/28 (11%)
ANK repeat 304..337 CDD:293786 2/32 (6%)
ANK 8 304..335 2/30 (7%)
PTZ00322 322..>429 CDD:140343 14/106 (13%)
ANK repeat 339..369 CDD:293786 3/29 (10%)
ANK 9 339..368 3/28 (11%)
ANK 10 381..410 5/28 (18%)
PKc_TNNI3K 469..722 CDD:270966 83/266 (31%)
Blue background indicates that the domain is not in the aligned region.

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