DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and Syk

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_036890.2 Gene:Syk / 25155 RGDID:3796 Length:629 Species:Rattus norvegicus


Alignment Length:645 Identity:192/645 - (29%)
Similarity:284/645 - (44%) Gaps:168/645 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 GLNIFTEHNGTKHSSFRGHPGKYHMNLEALLQSRPLPHIPAGSTAASLLADAAELQQHQQDSGGL 167
            |..:...||...|          |..:|..|..   .:..:|..|.:..||..  ..|.|:..||
  Rat    49 GFALSVAHNRKAH----------HYTIERELNG---TYAISGGRAHASPADLC--HYHSQEPEGL 98

  Fly   168 ------------GLQGSSLGGGHSSTTSVFESAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGG 220
                        |:|         ..|..||..     ||||:.        :.....::.|...
  Rat    99 VCLLKKPFNRPPGVQ---------PKTGPFEDL-----KENLIR--------EYVKQTWNLQGQA 141

  Fly   221 ENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAE-- 283
            ..|..:.:..|:..|...      .||                    ||..|:||.|||:.:|  
  Rat   142 LEQAIISQKPQLEKLIAT------TAH--------------------EKMPWFHGNISRDESEQT 180

  Fly   284 YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHS 348
            .|:.|..||.||:|..::: |..::.|.:||:|.||||..|..||:.:.:..||:||.:||.|:|
  Rat   181 VLIGSKTNGKFLIRARDNN-GSFALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLVEHYS 244

  Fly   349 -----------VPHE------GH--------------GLITPL---LYPAPKQNKP--------- 370
                       ||.:      ||              |:|:.:   .:|.|...||         
  Rat   245 YKPDGLLRVLTVPCQKIGVQMGHPGSSNAHPVTWSPGGIISRIKSYSFPKPGHKKPPPPQGSRPE 309

  Fly   371 -TV----------------------FPL------SPEPDEWEICRTDIMMKHK--------LGGG 398
             ||                      .|:      ||..|..||...::.:..|        ||.|
  Rat   310 STVSFNPYEPTGGAWGPDRGLQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDNELGSG 374

  Fly   399 QYGEVYEAVW--KRYGNTVAVKTLKEDT--MALKD-FLEEAAIMKEMKHPNLVQLIGVCTREPPF 458
            .:|.|.:..:  |:...|||||.||.:.  .|||| .|.||.:|:::.:|.:|::||:|..| .:
  Rat   375 NFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAE-SW 438

  Fly   459 YIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKL 523
            .::.|....|.|..:|:. .|...|. .::.:..|::.||.|||..|::||||||||.|:.....
  Rat   439 MLVMEMAELGPLNKYLQQ-NRHIKDK-NIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHY 501

  Fly   524 VKVADFGLARLMRDDT--YTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSP 586
            .|::||||::.:|.|.  |.|....|:|:||.|||.:.|.|||:|||||:||||:||..:||..|
  Rat   502 AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYFKFSSKSDVWSFGVLMWEAFSYGQKP 566

  Fly   587 YPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQE 646
            |..:..::|...|:||.||..|||||.|:||||..||.:|..:||.|.::...|.:.:.:
  Rat   567 YRGMKGSEVTAMLEKGERMGCPPGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYD 626

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 6/53 (11%)
SH2_ABL 268..363 CDD:198189 42/130 (32%)
PTKc_Abl 382..644 CDD:270645 110/276 (40%)
FABD 1584..1723 CDD:197885
SykNP_036890.2 SH2_N-SH2_Zap70_Syk_like 12..115 CDD:198191 17/89 (19%)
Interdomain A. /evidence=ECO:0000250 107..166 17/106 (16%)
SH2_C-SH2_Syk_like 163..261 CDD:198264 38/98 (39%)
Interdomain B. /evidence=ECO:0000250 259..364 17/104 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 289..330 6/40 (15%)
PTKc_Syk 370..625 CDD:133247 107/257 (42%)
Blue background indicates that the domain is not in the aligned region.

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