Protein Alignment Abl and tnk2

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: XP_031757304.1
• Gene: tnk2 / 100124754
• XenbaseID: XB-GENE-984470
• Length: 1151
• Species: Xenopus tropicalis
• Alignment Length: 878
• Identity: 228/878 - (25%)
• Similarity: 345/878 - (39%)
• Gaps: 177/878 - (20%)

  Fly   374 PLSPEPDEWE------ICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT-------VAVKTLKEDTM 425
            |.||.|.|.:      |...|:.|..|||.|.:|.|....|    ||       ||||.||.|.:
 Frog   128 PPSPPPLEGQQALTCLISEKDLSMFEKLGDGSFGVVRRGEW----NTPNGKLFNVAVKCLKTDVL 188

  Fly   426 ----ALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVA 486
                .|.||:.|...|..:.|.||::|.||.... |..::||....|:|||.||......|.: .
 Frog   189 TQPDVLDDFIREVNAMHSLDHINLIRLYGVVLTH-PMKMVTELAPMGSLLDRLRKNQGYFLIS-T 251

  Fly   487 LLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLM--RDDTYTAHAGAKFP 549
            |.:.|.|||:||:||||:.:|||||||||.|:..|.|||:.||||.|.:  .||.|......|.|
 Frog   252 LCHYAIQIANGMAYLESKRFIHRDLAARNILLSSNDLVKIGDFGLMRALPKNDDHYVMQEHRKVP 316

  Fly   550 IKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDK-GYRMERPPGCPP 613
            ..|.|||.|....||..||.|.|||.|||:.|||..|:..::.:.:.||:|| |.|:.||...|.
 Frog   317 FAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLVRPEDSPQ 381

  Fly   614 EVYDLMRQCWQWDATDRPTFKSIHHALEH-------MFQESSITEAVEKQLNANATSASSSAPST 671
            ::|::|.|||.....|||||.::...|..       ..|:....:.:..|:|...|.....|.:
 Frog   382 DIYNVMLQCWAHKPEDRPTFVALRDFLVEAQPTDMCALQDFQDPDKLHIQMNDVITVIEGRAEN- 445

  Fly   672 SGVATGGGATTTTAASGCASSSSATASLSLTPQMVKKGLPG-----GQALTPNAH---------- 721
               ....|....|...|....::.|:...|:...:.:.|..     |...|..||
 Frog   446 ---YWWRGQNKRTLKVGQFQRNTVTSVAGLSAHDISRPLKNSFIHTGHGDTVPAHCWGFPDRIDE 507

  Fly   722 --HNDPHQQQASTPMSETGSTSTKLSTFSSQGKGNVQMRRTTNKQGKQAPAPPKRTSLLSSSRDS 784
              ..:|........:.:..:..|:|.:.:.:               :..|.||:..:.:.|....
 Frog   508 LYLGNPMDPPDILGLDQGTARPTQLPSRAKR---------------EPPPRPPQPAARVKSKFHG 557

  Fly   785 TYRE---------------EDPANARCNFIDDLSTNGIHKLKTANYFSQ-TLSRNFK-------- 825
            |...               ::|:....|..||..|.||.||    |..: |.::..|
 Frog   558 TILRAPCSCPLCAIIVPLFQEPSYNTVNGEDDSITLGIKKL----YLKKPTPAKGLKLVKPSARV 618

  Fly   826 --TQIPTHHTHQIRTQQQQQQQSVQQQQQIVPLS-------VQQQAHQ-QQQKQQQYSIKKSSSC 880
              |::.......||:...::::.:...:.:.|:|       |:|.|.. .:...:.:|:...:..
 Frog   619 TGTKVTDRQLSDIRSNSLKEEELIDFGEDLSPISPGYLSPAVEQTAPSLAKLAMEAFSLLDKTPP 683

  Fly   881 SSFLYDILFRGLARDIN-SLTQRYDSETDPAADPDTDATGDSLEQSLSQVIAAPV---------T 935
            .|     ..|.|.|.:: :....:||:..||.....:...|..:..:..:.::.|         .
 Frog   684 QS-----PSRSLPRPLHPTPVVDWDSKPLPAPPAYDEVAQDEDDFEVCSINSSDVLLAQKEKVTV 743

  Fly   936 NKMQHSLHSGGGGGG-------IGPRSSQQHSSFKRPTGT--PVMGNRG---LETRQSKRSQLH- 987
            |.:|.:...|....|       ...|...:.:.|..|..|  |.:....   .|.:|....:|:
 Frog   744 NLLQRAREKGETNYGYVKEEERYNCRGKLEDNLFLPPKDTKQPSLSQTSEIFEELQQECMKRLNV 808

  Fly   988 ----SQAPGPGPPSTQPHHGNNGVVTSAHPITVGALDVMNVKQVVNRYGTLPKGARIGAYLDSLE 1048
                |.|..|. |||...|.|   ||.:.          :..|:..|....|:..|...:
 Frog   809 PASTSLASTPS-PSTSIMHIN---VTPSE----------DKPQIPPRIPIPPRPVRRNEH----- 854

  Fly  1049 D--SSEAAPALPA----TAPSLPPANGHATPPAARLNPKASPI-PPQQMIRSNSSGGVTMQNNAA 1106
            |  |.|.:||..|    ..|.|||.:..:.|.:...:|.|..: .|||  |||....:::....:
 Frog   855 DRWSGELSPAFGADEIGRPPLLPPRDPLSQPTSRTPSPMAFQVGSPQQ--RSNLCSPLSIGTYLS 917

  Fly  1107 ASLNKLQRHRTTTEGTMMTFSSFRAGGSSSSPK 1139
            .|..||          |.|..||.:....::||
 Frog   918 TSPGKL----------MPTTQSFASDPKYATPK 940

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189
		PTKc_Abl	382..644	CDD:270645	115/288 (40%)
		FABD	1584..1723	CDD:197885
tnk2	XP_031757304.1	SAM_TNK-like	34..95	CDD:188938
		PTKc_Ack_like	153..410	CDD:270636	112/262 (43%)
		SH3_9	418..467	CDD:434066	8/52 (15%)
		GTPase_binding	472..533	CDD:430374	8/60 (13%)
		Inhibitor_Mig-6	883..949	CDD:463294	18/70 (26%)
		UBA_ACK1	1074..1115	CDD:270460
		UBA_TNK1	1102..1141	CDD:270513