Protein Alignment Spn27A and SERPINF1

DIOPT Version :10

• Sequence 1: NP_652024.1
• Gene: Spn27A / 45815
• FlyBaseID: FBgn0028990
• Length: 447
• Species: Drosophila melanogaster
• Sequence 2: NP_002606.3
• Gene: SERPINF1 / 5176
• HGNCID: 8824
• Length: 418
• Species: Homo sapiens
• Alignment Length: 407
• Identity: 91/407 - (22%)
• Similarity: 182/407 - (44%)
• Gaps: 31/407 - (7%)

  Fly    48 GAASVPSGAGIYDDIDTF--VPFR--SDSHDPFSWHLLKTVLQNETADKNVIISPFSVKLVLALL 108
            |:....|...:.::.|.|  ||..  :.:...|.:.|.: |..:.:...||::||.||...|:.|
Human    29 GSPDPDSTGALVEEEDPFFKVPVNKLAAAVSNFGYDLYR-VRSSTSPTTNVLLSPLSVATALSAL 92

  Fly   109 AEAAGAGTQTQVELANTQTDIRSQNNVREFYRKTLNSFKKENQLHETLSVRTKLFTDSFIETQQK 173
            :..|...|::.:..| ...|:.|..::...|::.|::....   .:.|...:::..:..:..:..
Human    93 SLGAEQRTESIIHRA-LYYDLISSPDIHGTYKELLDTVTAP---QKNLKSASRIVFEKKLRIKSS 153

  Fly   174 FTATLKHFYDSEVEALDFTNPEAAADAINAWAANITQGRLQQLV--APDNVRSSVMLLTNLIYFN 236
            |.|.|:..|.:....|. .||......||.|.....:|:|.:..  .||.:  |::|| .:.:|.
Human   154 FVAPLEKSYGTRPRVLT-GNPRLDLQEINNWVQAQMKGKLARSTKEIPDEI--SILLL-GVAHFK 214

  Fly   237 GLWRRQFAT--TFQGSFFRSKDDQSRAEFM-EQTDYFYYTTSEKLKAQILRLPYKGKNSLFVLLP 298
            |.|..:|.:  |....|:..::...|...| :......|.....|..:|.:||..|..|:...||
Human   215 GQWVTKFDSRKTSLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLP 279

  Fly   299 YALNGIHDLV-KNLENDELKSAQWAMEEVKVKVTLPKFHFDYQQNLKETLRSLGVREIFEDSASL 362
            ..:.....|: ::|.::.:......::.|:..:|:||....|:..:.::|:.:.::.:|:.
Human   280 LKVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLFDS---- 340

  Fly   363 PGLTRGADVAGK-VKVSNILQKAGINVNEKGTEAYAATVVEIENKFGGSTAIEEFNVNRPFVFFI 426
            |..::   :.|| :|::.:..:||...||.|    |.|......:....|...::::|:||:|.:
Human   341 PDFSK---ITGKPIKLTQVEHRAGFEWNEDG----AGTTPSPGLQPAHLTFPLDYHLNQPFIFVL 398

  Fly   427 EEESTGNILFAGKVHSP 443
            .:..||.:||.||:..|
Human   399 RDTDTGALLFIGKILDP 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn27A	NP_652024.1	serpinK_insect_SRPN2-like	64..443	CDD:381044	87/389 (22%)
SERPINF1	NP_002606.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..39		2/9 (22%)
		serpinF1_PEDF	41..413	CDD:381008	88/391 (23%)
		O-glycosylated at one site	371..383		1/11 (9%)