|
Fly 410 PAPPAAVGNPSVPL---------VPGGTPLLPCNTSAGSTALRRPQGQNNASSGSAAASGGGGSL 465
|:| .:|.:|: :.|..|:.| |||.|.|:||.|| :
Rat 5 PSP----AHPQLPILQTQMVSDGMTGSNPVSP------------------ASSSSPASSGAGG-I 46
Fly 466 TPTPLYTGNGPAALGGSGGLTPGT--PTSGSLLSPA---LGGGSGTPNSAAQEFSFKAKQEVYVM 525
:|..:.. .::|.|..|...|| |..|..||.| :..|.....|.| |.:.:||.|..:.
Rat 47 SPQHIAQ---DSSLDGPPGPQDGTTVPLEGFSLSHAADPINRGPKWEKSHA-EIAEQAKHEAEIE 107
Fly 526 QRISELQREGLWTERRLPKLQEPSRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKY 590
.||:||::||.|:.:||||:.||.|||.|||||.|||.||:|||||||:||:..|:|..:||.::
Rat 108 TRIAELRKEGFWSLKRLPKVPEPPRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRH 172
Fly 591 FQDKATAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIV 655
.:::....:||.:.::.:|:|:||.:|::|:.|||||||:|::|.|:::|||||:|||.||.|||
Rat 173 HEEQRQKEERARREEQAKLRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIV 237
Fly 656 DQTEKFSQQLVEGMNKSVA-----DTPSLNSSRLTS----PKRESDD---DFRP-ESGSEDDEET 707
.||||:|..|.:.:|:.:| .:|.|.||...| |....|| ||:| |...||||||
Rat 238 GQTEKYSDLLSQSLNQPLASSKAGSSPCLGSSSAASSPPPPVSRLDDEDGDFQPQEEEEEDDEET 302
Fly 708 IAKAEE----DAADVKEEVTALAKESEMDFDDFLNDLPPGYL-----------------ENRDKL 751
|...|: ||...:.|:..|..|.|:..::.|..|||..| :..::.
Rat 303 IEVEEQQEGNDAETQRREIELLRHEGELPLEELLRSLPPQLLGGPFSPSQTPSHDSDTPDGPEEN 367
Fly 752 MKEEQSSAIKTETPD-------------DSDDSEFEAKE-ASDDDENTISKQEEAEQEIDHKKEI 802
::||.|..::.:.|. |.||.||.|.| .::|:|:||:.:|:.|.|:||..|:
Rat 368 IEEEPSQDLEVDPPSSSVTQCNKQCWHPDEDDEEFTANEDEAEDEEDTIAAEEQLEGEVDHAMEL 432
Fly 803 DELEADNDLSVEQLLAKYK-----------SEQPPSPKRRKLAPRDPELD---------SDDDST 847
.||..:.:||:|:||.:|. |......:..:....|.||: .:|.|:
Rat 433 SELAREGELSMEELLQQYAGAYAYDASAPGSGNSEDEEEVEANSSDCELEETRDVEEAAQEDSSS 497
Fly 848 AVDSTEE-------------------SEDAATEDEEDLSTVKTDTDMEEQDEQED-----GLKSL 888
..||.|| ||::.:::.||..: ::..|.|::||.:| |::.|
Rat 498 QSDSAEEHSEDEEDEHSEEEMSGSSQSEESESDESEDAQS-QSQADEEQEDEGDDDDDDFGVEYL 561
Fly 889 MA------DADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVVTPVPFLLKH 947
:| :.|..||....|.|......|: :.|.||.||||||||.||::|.|.||:|.||:.
Rat 562 LARDDERSEVDGGSGPPTPGPTTTLGPKKE--ITDIAAAAESLQPKGYTLATTQVKTPIPLLLRG 624
Fly 948 SLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLN 1012
.|||||||||||||||.|:|||||||||||||||||||:|||||||.|||||||||:||:|||||
Rat 625 QLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLN 689
Fly 1013 WEMEFKKWCPGFKILTYYGSQKERKLKRVGWTKPNAFHVCITSYKLVVQDQQSFRRKKWKYLILD 1077
||||.|:|||.||||||||:||||||||.||||||||||||||||||:||.|:||||.|:|||||
Rat 690 WEMELKRWCPSFKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILD 754
Fly 1078 EAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPM 1142
||||||||||||||.||||:::||||||||||||.|||||||||||||:||.||||||||||||:
Rat 755 EAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPL 819
Fly 1143 TGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRA 1207
||||||:.||||.|:.|||||:|||||||:|.:|||||||||||||.||||.|||.||:|||::.
Rat 820 TGMIEGSQEYNEGLVKRLHKVLRPFLLRRVKVDVEKQMPKKYEHVIRCRLSKRQRCLYDDFMAQT 884
Fly 1208 KTRETLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQI 1272
.|:|||.||:.:||||:||||||||||||:|:.||..|||...||.|.|..||....|..|..||
Rat 885 TTKETLATGHFMSVINILMQLRKVCNHPNLFDPRPVTSPFITPGICFSTASLVLRATEVHPLQQI 949
Fly 1273 NLETLNLLLLHLEQTMTAYVSH----KSRLLAPPRKLIEDIDTAPLPAPR--------------C 1319
::...: |:.||..::.|.:. :.|| .|:::.:|.|||.|.|| .
Rat 950 DMGRFD--LIGLEGRVSRYEADTFLPRHRL---SRRILLEIATAPDPPPRPKPVKMKVNRMLQPV 1009
Fly 1320 PNGKYRFHIRVRS---------------AELAQRIKLNAV--------KVGASPAMRLEGSKIMP 1361
|..:.|..:.|.| .|::.:..|..| .|.|||| |:.::|
Rat 1010 PKQEGRTVVVVNSPRAPLGPVPVRPPPGPEVSTQPTLGPVPPVLPTPLMVSASPA----GTPVVP 1070
Fly 1362 ----------------------------------------------------------------- 1361
Rat 1071 ASRPPGPVLLSPLQPNTGPLPQVLPSPMGVMSGTSRPPTPTLSLKPAPPAPVRLSPAPPPGSSSL 1135
Fly 1362 -----------------------------------------------MRNLLPSGRV-------- 1371
|:..||||.|
Rat 1136 LKPLTVPPGYTLSPVAATTTSSTIATVTTTAVPAPNSTPQRLILSPEMQARLPSGEVVSIGQLAS 1200
Fly 1372 -----------------------------------------LKR-----VSAS------INPVNM 1384
|:| |||. ..|.::
Rat 1201 LAQRPVTSAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHV 1265
Fly 1385 AL----------KPV-VINSVVTTTSSSTTASSP-------------TGALSV------------ 1413
|| .|| |:.|..:||.:.|..|.| ||.:.:
Rat 1266 ALIQAVAPTPGPTPVSVLPSTPSTTPAPTGLSLPLAANQVPPSMVNNTGVVKIVVRQAPRDGLTP 1330
Fly 1414 ------------------------LSNSKL----LG-ARSQINAPT------------------- 1430
|:.|:| || .|:.|..||
Rat 1331 VPPLAPAPRPSSSGLPAVLTPRPTLTPSRLTSPTLGTTRTPIPTPTLVRPLLKLVHSPSPEVSAS 1395
Fly 1431 ---------------------PAKVAKTMQDGKPFF----------------------------- 1445
||..:.|:.:..|..
Rat 1396 APGAAPMTISSSLHMPSSLPGPASSSMTIHNSSPLSSPVVSSTVSVPVSSSLPISVPTTLPVPAS 1460
Fly 1446 -----------------------------------------------------------YLTPAT 1451
.|:|..
Rat 1461 APLTIPITAPLPVSDLGPALLTGVTPALAVVSAASGPPLASAGVSPSVSALALGLATTPALSPPQ 1525
Fly 1452 NSG------------------------------------------AAGARLTL------------ 1462
.|| :|.|:.:|
Rat 1526 TSGHSLLLATTSSHVPGLNSAVAPACSPVLVPASALTSPFPISPSSAPAQASLLAPAPSTSQALA 1590
Fly 1463 TSKTTASASTTT-------------------------------------SRTTVTAST-----TS 1485
||....:||.|| |.|.|:|.| :|
Rat 1591 TSLAPMAASQTTILGPSPTPPLAPLPVLAASQTPLPAMTPPSMSGAPLPSSTLVSAPTSVLAPSS 1655
Fly 1486 GQQLIRDPIVKDLA-------------------------TH------------------------ 1501
.|.|:..|:...|: ||
Rat 1656 TQTLVSTPVSSPLSSLASTQTLTLAPTLAPTLGGLSPSQTHSLGTGSPQGPFPIQTLSLTPASSL 1720
Fly 1502 VKSTVQKQSIANG---------------------------------------------------- 1514
|.:..|..|:|.|
Rat 1721 VPTPAQTLSLAPGGPVGPTQTLSLAPSSPVGPAPAHTLTLAPAASSASLLVPTSVQTLTLSPAPV 1785
Fly 1515 --------------------------------------------------KTEPEEET------- 1522
|.|||..|
Rat 1786 PVPTLDPSATQTLALAPALTQAPASQASSLVSASGAASLPVTMVNRLPVPKDEPETLTLRSGPPS 1850
Fly 1523 -------------------EAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCRE 1568
....|:.:..|.:.||:||...|:|:..::.......|:|| .|
Rat 1851 PLPTATSFSGPRPRRQPPPPPRSPFYLDSLEEKRKQQRSERLERIFQLSEAHGALAPVYG---TE 1912
Fly 1569 AIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLN---HLLKSF-EERCADLKPVFANFVIY 1629
.:..| :|.:......|..: ...:|...|:.. |....| ::|...|..:...|:..
Rat 1913 VLDFC-----TLPQPVASPIGPRS--PGPSHPIFWTYTEAAHQAVLFPQQRLDQLSEIIERFIFV 1970
Fly 1630 VPSVCAPRIRRYVQNLSSTH---W--QHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQ 1689
:|.|.|| ..:|.:.| | .|:...:..:...|.|:...||.|:..|.|:|||.||||
Rat 1971 MPPVEAP-----PPSLHACHPPPWLAPHQAAFQEQLACELWPRARPLHRIVCNMRTQFPDLRLIQ 2030
Fly 1690 YDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMER 1754
||||||||:..||||||..|||||||||||:||||||.||.||||:||||||||||||||.||||
Rat 2031 YDCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMER 2095
Fly 1755 FNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSE 1819
||.|||||||||||||||||:||||||||:||||||||||||||||||||||||||||||||:||
Rat 2096 FNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLISE 2160
Fly 1820 RTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQEKSENKDRIVAT 1884
||:|.||||||||||||.|||||||||||.|||..||::||.|...|...||
Rat 2161 RTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEEPPGSS------------- 2212
Fly 1885 TTLSDTPSTVVET--EKQSLRAFEHALAAAEDEQDVQATKTAKAEVAADLAEFDEN--IPIATED 1945
:|..|....|| .||: ...|.||..||||:|::|...||||..|:||||:|| .|....:
Rat 2213 --VSSVPEEEEETVASKQT-HILEQALCRAEDEEDIRAATQAKAEQVAELAEFNENEGFPAGEGE 2274
Fly 1946 PNAEGGP---QVELSKADLEMQNLVKQLSPIERYAMRFVEETGAAWTAEQLRAAEAELEAQKREW 2007
..:..|| ..|:|:|:.|:..||:||:|||||||:|:|.:....:.|:|:.||.::||.:::.
Rat 2275 EASRPGPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQVEAARKDL 2339
Fly 2008 -----EANRL-------------------AAMHKEEELLKQE----TEAEEMLTYSRKD------ 2038
|..|| ...|:..:.:|.. |...|.|..:|.:
Rat 2340 DQAKEEVFRLPQEEEEGPGAGDEMSCATSGVSHRRSKKVKAPERLGTRVSERLRGARAETQGANH 2404
Fly 2039 ----SSNQVWISRNTMEQMPMWC----------------------------------PPTPPQDN 2065
||:| :.||. :|..| ||.||
Rat 2405 TPVTSSHQ---TCNTF--VPPRCSPVRERIPRPRPAPPPAPPAPPPAASPAPAPAPAPPAPP--- 2461
Fly 2066 DNDIYIDYSLSFMYELEPIAETDLPPVYVRKEHKRSRTDAGYDGSRRPNKMRREDNYVPPRSLFD 2130
.|:....||| ||| .
Rat 2462 ----------------PPVLPPVLPP-------------------------------VPP----P 2475
Fly 2131 RPTPQLARLRRELKSQRFRGSFKPNMPIPGLKPQLPTKPLTEPEAMAEWCVFEDMAI-------- 2187
.|.| .|..|.|...|..|...:....|.| :...:|.
Rat 2476 PPAP------------------SPPAPSPAPPPPAPAASVASAPASA---ITSSLATAPIPISAP 2519
Fly 2188 -------LHVLVN----LQGLPCSLMLLSPGQTPNWDLVSEMVNFCSKTYRSARQCRWRYETHIQ 2241
:|:|.: ||..||| ||..||
Rat 2520 NPVTILPVHILPSPAPLLQLPPCS----SPASTP------------------------------- 2549
Fly 2242 PREEGKVVESPKKQKKLKPT---------LRTEYLKSPLRYL------RTTQLYVSDNNASFYKT 2291
|.....| || |.|....:||..| ..|.|.:..........
Rat 2550 ----------PSACTPL-PTCTPLPAQTSLLTSSSPAPLDSLPVPISPGVTNLLLDSGEVEVCTQ 2603
Fly 2292 MRSRFDSIKTAYLKKAPPPKRQFSAPSLMNPKHMEVLQEFGILNYDQPVSPQNIAAMKANKIREK 2356
..:..:|::...:..:.........|:.:.|..::||.| ...:.|:.|...:.::|..|.:.
Rat 2604 ELAPVESLELPGMTNSEASLVSLVPPNDLLPVAVDVLPE---SEKNLPLIPAPSSTLEAESIPDD 2665
Fly 2357 Q--------RGQQMSQPPVGVGVVQQMQQQSQQQQQPAPPPLPQQQQPQQVVQQVQQQQQQQQQQ 2413
| .|...:..|.|..:...:.:.:..:. ||.....:|.|:
Rat 2666 QEQEVPGSVEGTNRTLLPGGGELTVSLSESNGLEL----PPSAASDEPLQL-------------- 2712
Fly 2414 QQQQVVQQQLPTVSNVQQTLPVQQTV-------ELVQQQPT--TTTTVAVPAAGGQLQQLQIQHL 2469
|.|..|::.|..||..| |||:.:.| :|::.|..:..|.|.....:..
Rat 2713 ---------LETHRNLEDTREVQTPVSNSEKPQELVRAEVTAPSTSSSATSSPEGPLPARPPRRR 2768
Fly 2470 TSSNVS---------------------PGQQTAILLHQPQQQLRTHPGQGGQSNTQQLVKTIVGT 2513
||::|. ||:...::..:...:.|.| ::....||..:...
Rat 2769 TSADVEIRGQGSGRTGQPPGPKVLRKLPGRLVTVVEEKELVKRRRH-----RATASTLVPGVSEV 2828
Fly 2514 SSSLTAGQLQQLA-QQSAVASGG--QSSVSVVLTTPVQ-----------TLPSVVQPQIGSGAQI 2564
|:|..:..:..:: .:|:..|.| :::.:..|:||.| .:.....|:.|.||::
Rat 2829 SASPRSPSIHSMSGPESSPPSSGPCEAAPTSSLSTPTQHTFIACRHNELGITGGGSPENGEGAKL 2893
Fly 2565 VSISSQTLPV-----------NSSP-QLGSIVQTQSLPQVVS------VSTLPTVGTVLTTTANQ 2611
:.|.|. |.|| ..|..| ...|..:| |..:|...|| |.||.:
Rat 2894 ----AITPPAVKRRRGRPPKKNRSPADAGRGV--DEAPSSISKGKTNGVDPIPGPETV-TATAAE 2951
Fly 2612 PQQQHQTTAVTTLNTTMLRGQRIVSTAAGNTLQQRTTAGGQ----SIVSMP---NLGQGASPSQF 2669
|..:.|..|...:: :.:.|:.:......:.|...... ..:|.| ||.....|..|
Rat 2952 PDLKPQPLAPQPVH----KPEPIILSPVEKRRRGRPPKARDLPIPGTISSPGDGNLESRTQPLPF 3012
Fly 2670 QTQLR-LAAVPTSPATQTTQLVTTKGIPVSALQQGGKTTVIPVTQQSGGAHIQLYRQRSLKVLQT 2733
...|. |.|.||:.|...|.:..:...|.....:..|....|...| |..|....| .||::
Rat 3013 PATLTPLLACPTAVANTVTTVTISTSPPKRKRGRPPKNPPSPRPSQ----HPVLDPDSS-SVLES 3072
Fly 2734 T---TQAVPSGSAGATGATANLVQAGGTIIQASNMATHVTSQKVAVSGMPGTSTTVQAGNVVSSV 2795
. .|..|.|.|.:.|:::: ...|...|.:...::...||.|..: .|::|.:|
Rat 3073 CGLGVQRQPLGQAESEGSSSD--------EDGSRPLTRLARLRLEAEGMRGRKS---EGSMVMAV 3126
Fly 2796 2795
Rat 3127 3126
| 
