Protein Alignment fwd and STT4

DIOPT Version :10

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: NP_013408.1
• Gene: STT4 / 851014
• SGDID: S000004296
• Length: 1900
• Species: Saccharomyces cerevisiae
• Alignment Length: 1756
• Identity: 354/1756 - (20%)
• Similarity: 592/1756 - (33%)
• Gaps: 589/1756 - (33%)

  Fly   190 PSPSVSQNNTSSATGRMSS----PHSQSSLSIACEPHSASTTTLSSLGS-DLGNGNGSTVPAFL- 248
            |.|.:.:...:..:|:...    |...||.|:.........||:..|.| |:.:|...|..|.|
Yeast   460 PVPVLRERQLTITSGKNIEKDYFPLRNSSASLDGTGALLGNTTVGQLSSHDVNSGATMTYHASLI 524

  Fly   249 ---MAAPVTLPIGGQMPTIKCLPGASSAASTPKHSRYSKPRLSLSRVFNHSMPSVHGRPNLSLA- 309
               :||..|:.......:|..|   :.:..|.|.:..||   .|..|..:|:..:  .||.||.
Yeast   525 SNCVAATTTIASYYNTQSITAL---TISILTQKVNSMSK---ELDGVILNSLARL--APNTSLTE 581

  Fly   310 -------------------PAGVPGSVNPPKRISTHQ---RNLSLD--FRSMGILLPPVSQVTNN 350
                               .:.:..::...|.:.:.:   |:.|.|  |..:..||..:  :.:.
Yeast   582 FSLLLKFFKSRTVIATKIDDSALLKNIIKAKCVISKELLARHFSSDLYFMYLHDLLDSI--IASG 644

  Fly   351 HINHTQHHRNRSLDSALQRIPEVEVSSPNAESENTFCSPSILGATMCSKIATTAATVTSALSPPG 415
            .:...:|||           |:.|:|                  .:..:|||....:.:.|..||
Yeast   645 EVERLEHHR-----------PQTEIS------------------RVADQIATYLEPLAALLPVPG 680

  Fly   416 -TPTPALMSTACTPTIGAVKGN-VQH------PVPKHEQSISLAAACRSSAVVESCP-------- 464
             ||.........|........| |.|      |:.|...|..|..|..|..:....|
Yeast   681 DTPLDINKDEVTTNKFRNAWFNFVIHGYHLGGPIVKRNFSFLLTIAYNSPPLASEFPANNKELSL 745

  Fly   465 ---TLRMRPKSSESVAANGQEMIGVIVSSTGNGSSSSNNSCSSAGSTKKREDLTSLGSDDSGIIC 526
               |:..|..|:|::....|::.....::.....::|::......:....|.          |.|
Yeast   746 EMNTILRRGSSNENIKQQKQQITEYFNTNIVQYRTTSSSKIMFLAAAVLLET----------IRC 800

  Fly   527 GSESDQISLNRICHSHESLDSGEMDADADAEEECVDLMDTTSIDEEYNIMQPDHLCLYPPQAAST 591
              |:...|...:..|..|:.||.:       |:|:.::..:.|.:...::|..:..::..:..:.
Yeast   801 --EAGDCSKTLLYFSDPSILSGSI-------EKCIAVLSVSMIRKYARLIQKGNDAIFNSKMIAQ 856

  Fly   592 ELDCRTLRPSRKQKRQQQQVLER-----KNLPSQ--NQIESEDSVDAGVDARTRYRVMNMSQAAI 649
            :|:...|..|.::...|......     :::||.  :.:             :.|.:::|..|..
Yeast   857 QLNNLLLCLSHREPTLQDAAFHACEIFIRSIPSSLCHHL-------------SLYTLLDMLTALF 908

  Fly   650 NVELGTASNEIDPDVNYRESHQDPIADAPSLSTPSVASTASATPSVTP-TPIATPTPTESTK--- 710
            :..|.:.:::.:|...::..|.......||.|:....:.:....|... ..|......:.||
Yeast   909 DSILDSEAHKFEPRYEFKLKHSKTTILVPSSSSWRATTLSRLHKSAKEWVRILLNRSNQDTKILL 973

  Fly   711 --------------------------------NDQVLFK-NFFGATK-NAI-------------- 727
                                            .|:.|.: .::|..| |.|
Yeast   974 QSYISDLGEYSRLNSVEFGVSFAMDMAGLILPADKELSRLTYYGPEKPNTISGFISLHSWRSKYL 1038

  Fly   728 FRTA----------------QSIIENHEKKNAAKQKEQPD--HSGTVSLVGSPNGGSSVPQDLVK 774
            |.||                |:|.:|....|....|:..|  ...|..|:......:|:..|:|.
Yeast  1039 FDTAITSSPEDIKRQIGISTQNIRKNLTLGNKIITKDVTDFLDMATALLILGNGAPASLIYDIVH 1103

  Fly   775 SPTDISKKKEFFSLLTSSSSIKAAAAAAANSAASTPPATPTEALAANSNSKLQPLSD------PS 833
            .|         |.:.| |:|:|.|...........|..... .|.......::.:.|      ..
Yeast  1104 IP---------FEVFT-SASLKIATNVWLTIITEKPEVAHL-LLVEVCYCWMRSIDDNIGLYSRD 1157

  Fly   834 ADLKVKERTLNLRLPGDSEG-------------------------SEGAL----------TKCS- 862
            .|||.:|.......|.|..|                         .||.|          |||:
Yeast  1158 HDLKGEEYQKMEYSPYDKAGINRDAKNASQAMQPHLHVIKFFASHFEGTLFQSDFLLKIFTKCAL 1222

  Fly   863 -SINSIHKLKL-PVPGVVKYFISEKAPVSDVLQKPEKGQS------------GLLRFFESPVFNI 913
             .|.:::|..| |...::::.:...|.:  ||....|..|            |.|.:|:.|
Yeast  1223 YGIKNLYKASLHPFARMIRHELLLFATL--VLNASYKQGSKYMGRLSQEITNGALSWFKRP---- 1281

  Fly   914 HFAVHYLFYSKEPGVLSFIGNKIFSFPDQEVDLYIPQLVVMYIQMDELAEVLDPYLTIRCRKSVD 978
               |.:.|.|.|..:              :.||.:.:  .:::|:::|:.::..:    |.|  |
Yeast  1282 ---VAWPFGSNELKI--------------KADLSVTR--DLFLQLNKLSSLMSRH----CGK--D 1321

  Fly   979 FSLKCLWLLEAYNYQVDSLGNSHNSSRKSKLALMKEIFSKREHKQTQ--------------NDLK 1029
            :.:        .||                       |...|.:|.|              |:|.
Yeast  1322 YKI--------LNY-----------------------FLASEIQQIQTWLTPTEKIEGADSNELT 1355

  Fly  1030 SAGTGGLHVGEPRSVVALAKKTHHRSQSDATVLLADFRSPHTLSISHRMYQQPPYTTQTLPTTPA 1094
            |.........:|...:.|.::.:.:...|..|
Yeast  1356 SDIVEATFAKDPTLAINLLQRCYSKKAEDVLV--------------------------------- 1387

  Fly  1095 KLCLGDLTSGHAFDNGCTCFETVRGQVNGLLGQRTLCSCGAPKTSPQKEFMKALMNVGKNLTSWP 1159
                                        ||:.:..|...|:|  |....|:|     |.:|:
Yeast  1388 ----------------------------GLVAKHALMCVGSP--SALDLFIK-----GSHLS--- 1414

  Fly  1160 SKAEKTSALRMS----LNLINKNLPARVW--------LPLYSDIPHHVVRITEEKTAVLNSKDKT 1212
            ||.:..:.|..:    |..||..||.  |        ..:||                |.|:|..
Yeast  1415 SKKDLHATLYWAPVSPLKSINLFLPE--WQGNSFILQFSIYS----------------LESQDVN 1461

  Fly  1213 PYIIYVEVVEIPDIYTSPLIPKMMPSLRHTKS--EEHL-----DGSCLNSHQHLSCSRTSSCSSS 1270
            ....||              |:::..||:.|:  .|.|     ..|.|.||| :..:..::|...
Yeast  1462 LAFFYV--------------PQIVQCLRYDKTGYVERLILDTAKISVLFSHQ-IIWNMLANCYKD 1511

  Fly  1271 QQGTSCRRKKGADVDGGCGDAGPHNSCSNVHSLGGLQFQEDDV--------------WSQEE--- 1318
            .:|                                  .|||::              :||..
Yeast  1512 DEG----------------------------------IQEDEIKPTLDRIRERMVSSFSQSHRDF 1542

  Fly  1319 --------DEITA------QYLNMRKVSERDTISQ---------------------ISLDSCDSR 1348
                    ||:|.      .|:...|..::..|.:                     |.:|    |
Yeast  1543 YEREFEFFDEVTGISGKLKPYIKKSKAEKKHKIDEEMSKIEVKPDVYLPSNPDGVVIDID----R 1603

  Fly  1349 DQGPPVVFNIGDVRLRHCSNLSCENTKSFSNDPEDPSAAALKEPWHEKEKLIRESSPYGHLSNWR 1413
            ..|.|         |:..:......|.....|.:||.....||                 :..|:
Yeast  1604 KSGKP---------LQSHAKAPFMATFKIKKDVKDPLTGKNKE-----------------VEKWQ 1642

  Fly  1414 LLSAIVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLHQI 1478
              :||.|.|||.||:::|.||:.:|:.||....:|::|.||::...:...|:|:.:.|:||...:
Yeast  1643 --AAIFKVGDDCRQDVLALQLISLFRTIWSSIGLDVYVFPYRVTATAPGCGVIDVLPNSVSRDML 1705

  Fly  1479 KKNSNKSLKEYFIDEYGSPSGESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSDGHIIH 1543
            .:.:...|.|||..::|:.|...|:.|:.|||:|.|.|.:||||||.||||||||::...||.:|
Yeast  1706 GREAVNGLYEYFTSKFGNESTIEFQNARNNFVKSLAGYSVISYLLQFKDRHNGNIMYDDQGHCLH 1770

  Fly  1544 IDFGFILSISPKNLGFEQSPFKLTPEFVEVMGGT-SSEHWREFNKLLLVGMMSARKHMDRIINFV 1607
            ||||||..|.|..:.||..|||||.|.|:||||: .:..:.:|.:|.:...::||.|::.||..|
Yeast  1771 IDFGFIFDIVPGGIKFEAVPFKLTKEMVKVMGGSPQTPAYLDFEELCIKAYLAARPHVEAIIECV 1835

  Fly  1608 EIMRSNAHLPCFKNGCSGTVQNLRKRFHMNLTEQEMERKVEQLVQDSLKSLSTKLYDGYQYYTNG 1672
            ..|..:. |||||.  ..|::|||.||....|:.|....::.|::.|.:|:.||.||.:|..|||
Yeast  1836 NPMLGSG-LPCFKG--HKTIRNLRARFQPQKTDHEAALYMKALIRKSYESIFTKGYDEFQRLTNG 1897

  Fly  1673 I 1673
            |
Yeast  1898 I 1898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	112/290 (39%)
STT4	NP_013408.1	TEL1	1..1900	CDD:227365	354/1756 (20%)