Protein Alignment fwd and Pi4kb

DIOPT Version :10

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: XP_038959158.1
• Gene: Pi4kb / 81747
• RGDID: 621214
• Length: 862
• Species: Rattus norvegicus
• Alignment Length: 958
• Identity: 376/958 - (39%)
• Similarity: 537/958 - (56%)
• Gaps: 167/958 - (17%)

  Fly   785 FFSLLTS---SSSIKAAAAAAANSAASTPPAT------PTEALAANS-NSKLQPLSDPSADLKV- 838
            |..||.|   |:|::|.:.|.|.......|||      ||.:.:.|: .|.|..:::...:|.|
  Rat     4 FLHLLMSSGFSNSLEARSLAVAMGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVI 68

  Fly   839 --------------KERTLNLRLPGDSEGSEGALTKCSSI-NSIHKLKLPVPGVVKYFISEKAPV 888
                          |.:.|:..:...|:||...|.....: |.|..|..| |..::....|..|
  Rat    69 DPEVAQKACQEVLEKVKLLHGGVAISSKGSPLELVNGDGVDNEIRCLDDP-PTEIREEEDEMEP- 131

  Fly   889 SDVLQKPEKG-----------QSGLLRFFESPVFNIHFAVHYLFYSKEPGVLSFIGNKIFSFPDQ 942
             .|:....||           ||.|||.|||.:|:|..|:.||:.||||||.::|||::|.|.::
  Rat   132 -GVVSGTAKGTRRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNE 195

  Fly   943 EVDLYIPQLVVMYIQMDE-LAEVLDPYLTIRCRKSVDFSLKCLWLLEAYNYQVDSLGNSHNSSRK 1006
            :||.|:|||:.|||.||| :.:.:.||:..|||:|::|||:|..||.||:..:......|:...|
  Rat   196 DVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTK 260

  Fly  1007 -SKLALMKEIFSKREHKQTQNDLKSAGTGGLHVGEPRSVVALAKKTHHRSQSDATVLLADFRSPH 1070
             .||.|..|:  |..|::.:....|..        |.:.::.:|:||.||:||||.
  Rat   261 LRKLILSDEL--KPAHRKRELPTLSPA--------PDTGLSPSKRTHQRSKSDATA--------- 306

  Fly  1071 TLSIS---HRMYQQPPYTTQTLPTTPAKLCLGDLTSGHAFDNGCTCFETVRGQVNGLLGQRTLCS 1132
            ::|:|   .|....|....:....:         :|..:.||                      |
  Rat   307 SISLSSNLKRTASNPKVENEDEELS---------SSTESIDN----------------------S 340

  Fly  1133 CGAP-KTSPQKEFMKALMNVGKNLTSWPSKAEKTSALRMSLNLINKNLPARVWLPLYSDIPHHVV 1196
            ..:| :.:|::||:|:||.:||.|.:.|:|.:||..|...|:|:|..||||||||. :...||||
  Rat   341 FSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPT-AGFDHHVV 404

  Fly  1197 RITEEKTAVLNSKDKTPYIIYVEVVEIPDIYTSPLIPKMMPS--LRHTKSEEHLDGSCLNSHQHL 1259
            |:...:..|||||||.||:|||||:|..:..|:. :|..:|.  :|.|:|.|:|. .|..:|:.
  Rat   405 RVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTN-VPARIPENRIRSTRSVENLP-ECGITHEQ- 466

  Fly  1260 SCSRTSSCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVHSLGGLQFQEDDVWSQEEDEITAQ 1324
                                          .||..::..|..:       :|:.||  .|:|...
  Rat   467 ------------------------------RAGSFSTVPNYDN-------DDEAWS--VDDIGEL 492

  Fly  1325 YLNMRKV--SERDTISQISLDSCDSRDQGPPVVFNIGDVRLRHCSNLSCENTKSFSNDPEDPSAA 1387
            .:.:.:|  :..|.|||.|:||..|::...||....||:|.|....|:...| :|..|||||||.
  Rat   493 QVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPT-AFKRDPEDPSAV 556

  Fly  1388 ALKEPWHEKEKLIRESSPYGHLSNWRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVR 1452
            ||||||.||.:.|||.||||||.||||||.||||||||||||:|.|:|:..:.||::|:|.||::
  Rat   557 ALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIK 621

  Fly  1453 PYKIVCLSNDSGLIEPILNTVSLHQIKKNSNKSLKEYFIDEYGSPSGESFRRAQKNFVQSCAAYC 1517
            ||||:.:|.|||:|||::|.||:||:||.|..||.:||:.|:||.:.|:|..||:|||||||.||
  Rat   622 PYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYC 686

  Fly  1518 LISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISPKNLGFEQSPFKLTPEFVEVMGGTSSEHW 1582
            |:.||||||||||||||..::|||||||||||||.||:|||||.|.||||.|||:||||.:.:.:
  Rat   687 LVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMF 751

  Fly  1583 REFNKLLLVGMMSARKHMDRIINFVEIMRSN---------------------AHLPCFKNGCSGT 1626
            ..:..|:|.|:::||||||:::..||||:..                     :.||||..  |.|
  Rat   752 NYYKMLMLQGLIAARKHMDKVVQIVEIMQQGCRRCSGASLSGPVVTVAQVICSQLPCFHG--SST 814

  Fly  1627 VQNLRKRFHMNLTEQEMERKVEQLVQDSLKSLSTKLYDGYQYYTNGIL 1674
            ::||::||||::||::::..|||:|..|::|::||||||:||.||||:
  Rat   815 IRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	176/309 (57%)
Pi4kb	XP_038959158.1	PI4KB_NTD	27..91	CDD:412074	12/63 (19%)
		PI4Kc_III_beta	554..862	CDD:270712	176/309 (57%)